Abstract: A composition or nanosuspension is described that includes water dispersible nanoparticles of a retinoid compound having an average particle size of less than about 500 nm. Also described, are pharmaceutical compositions intended for topical administration, including such a composition or nanosuspension. Uses of such pharmaceutical compositions in the treatment of skin diseases, particularly acne, ichthyosis and psoriasis are also described.

Abstract: Stable cream gel dermatological/cosmetic compositions useful, e.g., for the treatment of acne vulgaris, contain, formulated into a physiologically acceptable medium, a homogeneous dispersion of at least one dispersed retinoid, dispersed benzoyl peroxide, at least one lipophilic compound and at least one gelling agent.

Abstract: Lipid microcapsules are described that can include at least one lipophilic active substance, more specifically a retinoid, in a soluble form. Also described, are pharmaceutical compositions including the same and a method for the production thereof. Methods of using such a composition to treat dermatological pathologies are also described.

Abstract: The use of an NLRP3 inhibitor compound is described in the treatment of inflammatory skin disorders, in particular psoriasis and atopic dermatitis.

Abstract: A self-foaming composition for a topical application is described. The composition can include a medium which is cosmetically- or pharmaceutically-compatible with a topical application, and clobetasol propionate. The composition can include a small quantity of foaming surfactants. The composition includes: at least one intermediate composition B including a gas-generating agent; at least one intermediate composition A including an agent for activating the gas-generating agent; and clobetasol propionate being present in at least one of the intermediate compositions A and B. Also described, is a kit or a single container including a plurality of compartments including such a composition.

Abstract: A composition is described that includes benzoyl peroxide. The composition can be formulated for a leave-in topical application and can be provided in the form of a leave-in foam intended to be applied to the skin. The composition can include: at least one intermediate composition, at least one gas-generating agent, at least one agent that activates the gas-generating agent, and benzoyl peroxide. A kit or a single multicompartment container including such a composition is also described.

Abstract: The present invention is related to a pulse photodynamic therapy (or pulse PDT) treatment of photodamaged skin.

Abstract: Lipid microcapsules are described that can include at least one irritant active substance, more specifically a retinoid, in a soluble form. Also described, are pharmaceutical compositions comprising the same, and methods for the production thereof. A method of using the composition to treat dermatological pathologies is also described.

Abstract: A method is described for using ROR gamma t or ROR alpha to diagnose acne and/or to screen inhibitors of Th17 differentiation. Specifically described, are methods of inhibiting ROR gamma t or ROR alpha and use of the screened inhibitors in acne treatment.

Abstract: Indazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma ROR?t are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of ROR?t receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Abstract: A pulse photodynamic therapy (or pulse PDT) treatment of photodamaged skin is described.

Abstract: A diffusion cell is described that includes a receiver compartment and a tightening ring intended to be positioned above the receiver compartment in such a way that a membrane sample, such as a sample of a skin, can be arranged between the receiver compartment and the tightening ring. The cell further includes means for tightening by rotation of the tightening ring on the receiver compartment. Uses of such a diffusion cell, in particular for evaluating the penetration capacity of a compound of interest contained in an aerosol formulation, are also described. These uses can be applicable in an occlusive patch or semi-occlusive patch or in a formulation under occlusive or semi-occlusive conditions in the skin. The uses can also be implemented to evaluate the capacity of an aerosol formulation, an occlusive or semi-occlusive patch or a formulation under occlusive or semi-occlusive conditions to deliver a compound of interest through the skin.

Abstract: Stable dermatological/cosmetic emulsions useful, e.g., for the treatment of acne vulgaris, contain, formulated into a physiologically acceptable medium, a homogeneous dispersion of at least one dispersed retinoid, dispersed benzoyl peroxide, at least one fatty phase, at least one hydrophilic phase and at least one emulsifier.

Abstract: Lipid nanocapsules are described that include at least one irritating active ingredient, and more specifically a retinoid in solubilized form. Also described, are nanodispersions and pharmaceutical compositions including the same and methods of producing the same. The use of the pharmaceutical compositions in the treatment of dermatological pathologies is also described.

Abstract: The invention relates to the identification of microRNAs associated with acne and to the use thereof.

Abstract: Novel compounds, synthesis methods and use of the same in medicine and in cosmetics are disclosed. Also disclosed, are novel compounds and ligands that modulate RARs.

Abstract: Novel chemokine CXCR1 and CXCR2 receptor antagonist compounds of general formula (I) are described. Also described, are pharmaceutical compositions including the compounds, and use of the compounds and the compositions for the treatment of chemokine-mediated pathologies, more specifically in the field of dermatology.

Abstract: Benzimidazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma ROR?t are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of ROR?t receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Abstract: A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a backbone diol function of a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.

Abstract: The device for packaging and dispensing a product comprises a container provided with at least one variable volume compartment, and a dispensing head fastened to the container. The dispensing head comprises a mounting base, an internal piston that is movable in translation along a displacement axis Y-Y? and delimits, inside said base, first and second pumping chambers, and at least one actuating rod that extends through the pumping chambers and the piston and projects from either side of the mounting base. The actuating rod internally delimits a first feed duct in communication with a first outlet orifice of the dispensing head and a second feed duct separate from said first duct and in communication with a second outlet orifice of said head.