Patents Assigned to GE Healthcare AS
  • SYSTEM, METHOD AND APPARATUS FOR MINIMIZING DEAD LEGS IN A BIOREACTOR SYSTEM
    Publication number: 20200102204
    Abstract: An apparatus for minimizing dead leg spaces in a container or tubing includes a first member having a flange for attaching the first member to a wall of the container or tubing, the flange having at least one aperture, and a second member rotatably coupled to the first member, the second member having an upper end having at least one aperture, and an open distal end. The second member is rotatable relative to the first member between a closed position where the at least one aperture of the second member is misaligned with the at least one aperture in the flange to prevent the passage of fluid, and an open position where the at least one aperture of the second member is aligned with the at least one aperture in the flange to allow for the passage of fluid.
    Type: Application
    Filed: September 27, 2018
    Publication date: April 2, 2020
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Hanna-Leena Saukkonen, Benjamin Brown, Matthew Ouellette, Shanice Jones, Ralph Stankowski, Eric Faldt, Lauren Lisle
  • CHROMATOGRAPHY MEDIUM
    Publication number: 20200101398
    Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.
    Type: Application
    Filed: December 3, 2019
    Publication date: April 2, 2020
    Applicant: GE Healthcare BioProcess R&D AB
    Inventors: JAN BERGSTROM, GUNNAR GLAD, BO-LENNART JOHANSSON, JEAN-LUC MALOISEL, NILS NORRMAN, TOBIAS E. SODERMAN
  • Method for preparation of liquid mixtures
    Patent number: 10605710
    Abstract: The present invention relates to the preparation of liquid mixtures, and more particularly to the preparation of a liquid mixture, such as a buffer, wherein the conductivity of the liquid mixture is measured and the pH indirectly determined if the buffer concentration is known. Another object of the present invention is to provide a method of preparing a liquid mixture with a predetermined pH value by using conductivity as feedback control parameter.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: March 31, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Enrique Napoleon Carredano, Elenor Strandberg
  • Chromatography lab system including cooling compartment and identifying device
    Patent number: 10598638
    Abstract: A chromatography lab system comprising a cooling compartment arranged to hold both fraction collector devices and sample containers, whereby the cooling compartment comprises an identifying device which is arranged to identify the fraction collector devices such that fractions from the chromatography are collected only in the fraction collector devices.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bjorn Olovsson, Karol Lacki, Mikael Berg
  • Method of determining a nucleotide sequence of a nucleic acid segment from a region of interest in a biological sample
    Patent number: 10597697
    Abstract: The invention discloses a method for determining a nucleotide sequence of a nucleic acid segment present in a biological sample, comprising the steps of: a) generating a fluorescent image of the sample by a protocol comprising immunofluorescence detection of at least five different target proteins in the sample; b) selecting a region of interest of the sample by comparing the image to a predetermined criterion; c) removing a subsample from the region of interest, and; d) determining a nucleotide sequence of a nucleic acid segment present in the subsample.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: John Richard Nelson, Qingyan Au, Wei Gao, Ryan Charles Heller, Nicholas Hoe, Nam Tran, Nichole Lea Wood
  • Automated fluid handling system
    Patent number: 10598678
    Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: March 24, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Johan Blomberg, Mats Lundkvist
  • Method for baseline correction in a chromatogram
    Patent number: 10598640
    Abstract: The invention discloses a method for correcting a baseline in a chromatogram obtained using a buffer with at least one UV-absorbing component which is a weak acid or a weak base.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Gunnar Malmquist, Martin Hall, Nils Stafstrom
  • Electrophoresis separation method
    Patent number: 10598631
    Abstract: Method for electrophoretic separation using a separation gel arrangement with a gel member and one or more sample wells for receiving sample liquid to be separated, the sample wells being in fluidic contact with the gel member, the method comprising the steps: adding a sample liquid to be separated in one or more of the sample wells, applying an electric field over the gel member to drive an electrophoretic separation process, whereby sample constituents are drawn from the sample liquid in the sample well(s) into the gel member for separation, and when a removal criteria is met: discontinuing loading of sample constituents into the separation gel.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Kjell Larsson
  • BAG ASSEMBLY FOR CULTIVATION OF CELLS
    Publication number: 20200087605
    Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.
    Type: Application
    Filed: September 27, 2019
    Publication date: March 19, 2020
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
  • Method and composition for biomolecule stabilization
    Patent number: 10590408
    Abstract: The present invention relates to biomolecule stabilization to provide biomolecules, such as sensitive polymerases, in a convenient ready-to-go format. The invention provides a method and composition in which non-ionic surfactant or detergents of the polyoxyethylene cetyl ether family are used, preferably a Brij reagent or a combination of Brij reagents.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: March 17, 2020
    Assignee: GE Healthcare UK Limited
    Inventors: Peter James Tatnell, Elizabeth Mary Ashman
  • Fluid mixing in a disposable fluid processing system
    Patent number: 10589239
    Abstract: High accuracy mixing of fluids in a disposable fluid processing system with at least two pumps is provided by a method where a calibration fluid volume is pumped through each pump via a flow meter at at least one calibration pump speed while registering the flow rate using data output from the flow meter, a pump calibration function is calculated from the calibration pump speed and flow rate data and two or more operation fluids are mixed to a predetermined mixture ratio and predetermined flow rate by controlling the pump speed of the respective pumps in accordance with the pump calibration functions.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: March 17, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Patric Fricking, Bjorn Jaderlund
  • Dual run cassette for the synthesis of 18F-labelled compounds
    Patent number: 10584078
    Abstract: The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: March 10, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventor: Xavier Franci
  • Method for analyzing posttranslational modifications using GEL IEF and mass spectrometry
    Patent number: 10578625
    Abstract: The present invention relates to the field of proteomics and more specifically to a method for analyzing a sample possible containing peptides or modified peptides; in particular useful for biomarker discovery or validation of biomarkers. The method uses isoelectric focusing and mass spectrometry (MS) and enables identification of modified peptides with high resolution and predictability.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: March 3, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Peter Mats Oliviusson, Janne Lehtio, Rui Miguel Mamede-Branca
  • Lanthanide complex formulations
    Patent number: 10576169
    Abstract: The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: March 3, 2020
    Assignee: GE HEALTHCARE AS
    Inventors: Mikkel Jacob Thaning, Andreas Richard Meijer
  • Piston and process column
    Patent number: 10571441
    Abstract: The invention discloses a piston for a process column, said piston comprising a top side and a bed contact side, wherein said top side comprises a drainage trench.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: February 25, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Andreas Bergstrom, Stefan Kjell Eriksson
  • Cleaning of rotary valves
    Patent number: 10571033
    Abstract: Disclosed is a rotary valve 1 comprising a stator 20 and a rotor 40 generally in rotary sliding engagement with the said stator about a valve axis RA, the stator including a plurality of fluid ports 22, 26, 28, the rotor 40 being operable to selectively fluidically interconnect two or more of said ports during its rotary sliding engagement. The valve further includes an actuator (70) for disengagement of the rotor from the stator to enable efficient cleaning of the valve interconnections.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: February 25, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Bjorn Olovsson
  • Separation matrix
    Patent number: 10562007
    Abstract: The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used.
    Type: Grant
    Filed: July 22, 2008
    Date of Patent: February 18, 2020
    Assignee: GE Healthcare BioProcess R&D AB
    Inventors: Andreas Axen, Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Nils Norrman
  • Mixing unit for mixing fluids
    Patent number: 10561997
    Abstract: A mixing unit (100) for mixing of fluids is disclosed. The mixing unit (100) includes a mixing chamber (102) for holding one or more fluids and a driving assembly (104) operatively engaged to the mixing chamber (102). The driving assembly (104) is configured to oscillate the mixing chamber (102) for mixing the one or more fluids. The mixing chamber (102) of the mixing unit (100) enables better mixing of fluids in a convenient manner. Further less amount of cleaning fluids may be only required for cleaning the mixing chamber (102) after the mixing process. The mixing unit (100) can be used for mixing amino acids with different fluids however this unit can be used for mixing other fluids as well.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: February 18, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bjorn Olovsson, Daniel Carlsson, Mahias Osmark, Magnus Gamberg
  • NON-INVASIVE METHOD FOR PRESSURE MEASUREMENT
    Publication number: 20200046313
    Abstract: The present invention relates to the use of contrast-enhanced ultrasound using microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in a region of interest (ROI) of a subject. The method of the invention provides a non-invasive, direct, and accurate method for pressure estimation.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 13, 2020
    Applicants: THOMAS JEFFERSON UNIVERSITY, GE HEALTHCARE LIMITED
    Inventors: Flemming Forsberg, David Mills, John R. Eisenbrey, Kirk Wallace, Ipshita Gupta
  • Probe sheath
    Patent number: D877897
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 10, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventor: Matthew David Ouellette