Patents Assigned to Gen-Probe Incorporated
  • Patent number: 10711317
    Abstract: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: July 14, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Sylvia A. Norman, Jennifer J. Bungo, William L. Hanna, Neeraj P. Rao
  • Patent number: 10711297
    Abstract: An automated method for analyzing a plurality of samples within a housing of a self-contained system. The system is loaded with a plurality of samples, after which a first assay is performed on a first sample subset and a second assay performed on a second sample subset. The two assays include exposing the samples to a target capture reagent having a solid support for directly or indirectly immobilizing a target nucleic acid that may be present in one or more of the samples. The two assays may be performed with the same or different target capture reagents and target nucleic acids, but the receptacles for performing the exposing step have substantially identical geometries. Following the exposing step, an amplification reaction for amplifying a region of the target nucleic acid is performed with each sample. The amplification reactions of the two assays are performed in receptacles having different geometries.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: July 14, 2020
    Assignee: Gen-Probe Incorporated
    Inventors: David A. Buse, David Opalsky, Jason F. Rhubottom, Norbert D. Hagen, Jennifer L. Tidd
  • Patent number: 10711295
    Abstract: Provided are compositions, kits, and methods for the identification of Salmonella. In certain aspects and embodiments, the compositions, kits, and methods may provide improvements in relation to specificity, sensitivity, and speed of detection.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: July 14, 2020
    Assignee: Gen-Probe Incorporated
    Inventors: Michael R. Reshatoff, Edgar O. Ong, James J. Hogan
  • Patent number: 10689712
    Abstract: Compositions, reaction mixtures, kits and methods used in amplifying and detecting nucleic acids from various species of the class Mollicutes. Particular regions of the 23S rRNA or its gene have been identified as preferred targets for nucleic acid amplification reactions of a sample suspected containing at least one species of Mollicutes. Some oligomers comprise tag regions, target closing regions, promoter sequences, and/or binding moieties. Samples can be from any source suspected of containing a species of the class Mollicutes. Preferred sample sources include bioreactors, cell lines, cell culture wares and pharmaceutical manufacturing wares.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: June 23, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Shannon K. Kaplan, Kristin W. Livezey, Michael M. Becker, James J. Hogan
  • Patent number: 10689713
    Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: June 23, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jijumon Chelliserry, Kui Gao, Jeffrey M. Linnen
  • Patent number: 10688458
    Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: June 23, 2020
    Assignees: Gen-Probe Incorporated, Qualigen, Inc.
    Inventors: Scott S. Breidenthal, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
  • Patent number: 10676796
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of a 16S rRNA or its encoding gene from bacterial species associated with bacterial vaginosis. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: June 9, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventor: Damon K. Getman
  • Patent number: 10668472
    Abstract: A receptacle for minimizing evaporation of a fluid includes a single-piece body, a fluid-tight seal, a penetrable septum, and a lid coupled to the body. The body includes a first chamber having a first opening. The fluid-tight seal is affixed to a surface of the body that defines the first opening. The fluid-tight seal covers the first opening and is frangible. The septum covers the first opening and the fluid-tight seal. The lid has an opening axially aligned with the first opening. The septum comprises slits forming flaps The first chamber can be the only chamber containing a fluid, or the single-piece body may also include another chamber containing the fluid. The other chamber can be in fluid communication with the first chamber via a conduit. The fluid-tight seal can also cover the opening of the second chamber.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: June 2, 2020
    Assignee: Gen-Probe Incorporated
    Inventor: Byron Knight
  • Patent number: 10669595
    Abstract: Oligonucleotide primer useful for synthesizing a cDNA copy of HIV-1 nucleic acids from a broad range of HIV-1 subtypes, including M group and O group variants.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 2, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventor: Astrid R. W. Schroder
  • Publication number: 20200165599
    Abstract: Populations of target capture probes are provided that are useful for nucleic acid separation and purification. The probes of the population comprise a first region that is at least about 12 residues in length and comprises a poly(r) sequence comprising (i) a randomized sequence comprising G and A nucleotides, or (ii) a non-randomized repeating (A and G) sequence; and a second region comprising a first specific binding partner (SBP), wherein the SBP is capable of specifically binding a second specific binding partner (SBP2). Related combinations, methods, uses, kits, and reaction mixtures are also provided.
    Type: Application
    Filed: May 10, 2018
    Publication date: May 28, 2020
    Applicant: Gen-Probe Incorporated
    Inventor: Ankur Shah
  • Patent number: 10654041
    Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 19, 2020
    Assignee: Gen-Probe Incorporated
    Inventor: Byron J. Knight
  • Patent number: 10655165
    Abstract: The invention provides an improved stem-loop target capture oligomer and methods of use. Such a target capture oligomer has a target-binding segment forming a loop flanked by stem segments forming a stem. The stem segments are of unequal length. Such probes show little or no binding to immobilized probes in the absence of a target nucleic acid but offer good target sensitivity. The probes are particularly useful in multiplex methods of detection in which multiple target capture oligomers are present for detecting of multiple target nucleic acids (for example, detecting multiple polymorphic forms of a target gene).
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: May 19, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: James Carlson, Reinhold Pollner, Steven T. Brentano
  • Patent number: 10656077
    Abstract: A sample testing system includes a test receptacle support structure, an optical element positioned for transmitting electromagnetic radiation emitted or reflected by a sample disposed in a test receptacle supported by the test receptacle support structure, a cleaning member, and an automated transport arm configured to (i) detachably couple the cleaning member, (ii) move the detachably-coupled cleaning member into a position proximate to and/or contacting the optical element, and (iii) decouple the cleaning member.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: May 19, 2020
    Assignee: Gen-Probe Incorporated
    Inventors: Norbert D. Hagen, Byron J. Knight, David Opalsky
  • Publication number: 20200140928
    Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Group B Streptococcus (GBS; Streptococcus agalactiae) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
    Type: Application
    Filed: August 9, 2019
    Publication date: May 7, 2020
    Applicant: GEN-PROBE INCORPORATED
    Inventors: Barbara L. Eaton, Benjamin Grobarczyk, Yves Ozog, Renaud Close, Laurent Franzil
  • Patent number: 10641707
    Abstract: Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: May 5, 2020
    Assignee: Gen-Probe Incorporated
    Inventors: Robert E. Heinz, Dennis Newell, David Opalsky, Jason Rhubottom
  • Patent number: 10640836
    Abstract: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: May 5, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Sylvia A. Norman, Jennifer J. Bungo, William L. Hanna, Neeraj P. Rao
  • Patent number: 10626466
    Abstract: The present invention provides compositions, methods and kits for the species-specific detection of Pseudomonas aeruginosa.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: April 21, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Shannon K. Kaplan, Kristin Livezey, Jennifer J. Bungo, James J. Hogan
  • Patent number: D888279
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: June 23, 2020
    Assignee: Gen-Probe Incorporated
    Inventor: David A. Buse
  • Patent number: D888944
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: June 30, 2020
    Assignee: Gen-Probe Incorporated
    Inventors: Rolf Silbert, HongRan Peng
  • Patent number: D889642
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: July 7, 2020
    Assignee: Gen-Probe Incorporated
    Inventors: Rolf Silbert, HongRan Peng