Patents Assigned to Gen-Probe Incorporated
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Patent number: 11487959Abstract: A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.Type: GrantFiled: April 2, 2021Date of Patent: November 1, 2022Assignee: GEN-PROBE INCORPORATEDInventor: David Opalsky
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Publication number: 20220315989Abstract: A nucleic acid diagnostic system includes a unit-dose reagent compartment storing at least one unit-dose pack, one or more unit-dose pack loading stations for holding a unit-dose pack at a location that permits a substance transfer device to dispense a reconstitution reagent into each well of the pack, a unit-dose pack distributor configured to transfer a unit-dose pack from the unit-dose reagent compartment to one of the unit-dose pack loading stations, and an electrostatic generator disposed within the housing of the unit-dose reagent compartment and/or adjacent the one or more unit-dose pack loading stations. The electrostatic generator imparts an electrostatic charge to each of the wells of the unit-dose pack and/or to a lyophilized reagent pellet within each well so that the electrostatic charge positions and holds each lyophilized reagent pellet at a bottom of each respective well of the unit-dose pack.Type: ApplicationFiled: June 16, 2022Publication date: October 6, 2022Applicant: Gen-Probe IncorporatedInventors: David OPALSKY, Byron J. Knight
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Publication number: 20220307084Abstract: This disclosure provides oligomers, combinations of oligomers, compositions, kits, uses, and methods for detecting a C1orf43 nucleic acid, such as C1orf43 mRNA, such as human C1orf43 mRNA, in a sample.Type: ApplicationFiled: June 1, 2022Publication date: September 29, 2022Applicant: Gen-Probe IncorporatedInventors: Siobhán M. Miick, Paul M. Darby, Jo Ann Jackson, Damon Kittredge Getman
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Patent number: 11453919Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Group B Streptococcus (GBS; Streptococcus agalactiae) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.Type: GrantFiled: August 9, 2019Date of Patent: September 27, 2022Assignee: Gen-Probe IncorporatedInventors: Barbara L. Eaton, Benjamin Grobarczyk, Yves Ozog, Renaud Close, Laurent Franzil
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Patent number: 11447835Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis C virus (HCV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the 5? untranslated region of HCV and are configured to provide substantially equivalent quantification of different genotypes and variants of HCV.Type: GrantFiled: October 18, 2017Date of Patent: September 20, 2022Assignee: GEN-PROBE INCORPORATEDInventors: Siobhan Miick, Paul M. Darby, Jo Ann Jackson, Sheila M. J. Aubin
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Publication number: 20220291454Abstract: A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature.Type: ApplicationFiled: June 1, 2022Publication date: September 15, 2022Applicant: Gen-Probe IncorporatedInventors: David Buse, David Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
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Patent number: 11434521Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.Type: GrantFiled: February 10, 2022Date of Patent: September 6, 2022Assignee: GEN-PROBE INCORPORATEDInventors: David A. Buse, David Howard Combs, Byron J. Knight, Norbert D. Hagen, David Opalsky, Jason F. Rhubottom, Keith Moravick, Tyler Moore, Anita Prasad, Bruce Richardson
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Patent number: 11420207Abstract: A receptacle includes an upper portion having a cylindrical portion and an open end and a lower portion depending from the upper portion, where the lower portion is tapered and has a closed bottom end. The receptacle may include a radially-extending annular ring with a flat or sloped bottom surface and disposed on an outer surface of the receptacle at a transition between the upper portion and the lower portion and/or a radially-projecting lip circumscribing the open end, which may be configured for inter-locking engagement with a mated cap inserted into the open end of the upper portion. Embodiments may include one or more longitudinally-oriented grooves formed in an inner surface of the upper portion. The receptacle may be a unitary plastic structure.Type: GrantFiled: January 2, 2019Date of Patent: August 23, 2022Assignee: GEN-PROBE INCORPORATEDInventor: Byron J. Knight
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Patent number: 11402330Abstract: A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.Type: GrantFiled: July 24, 2020Date of Patent: August 2, 2022Assignee: GEN-PROBE INCORPORATEDInventors: David Opalsky, Srajan Raghuwanshi, James Bui
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Patent number: 11396673Abstract: The invention provides compositions and methods for making closed nucleic acid structures in which one or both strands are continuous. The closed nucleic acid structures can be used as sequencing templates among other applications.Type: GrantFiled: December 17, 2018Date of Patent: July 26, 2022Assignee: GEN-PROBE INCORPORATEDInventors: Norman C. Nelson, Jijumon Chelliserry
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Patent number: 11384387Abstract: The disclosed disclosure is related to methods, compositions, and kits for targeting Adenovirus, nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers. Methods include uniplex and multiplex amplification and detection reactions.Type: GrantFiled: March 23, 2018Date of Patent: July 12, 2022Assignee: GEN-PROBE INCORPORATEDInventors: Mehrdad R. Majlessi, Ankur Shah, Amber Hillius, Pamela Douglass, Daniel Kolk
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Patent number: 11377688Abstract: This disclosure provides oligomers, combinations of oligomers, compositions, kits, uses, and methods for detecting a C1orf43 nucleic acid, such as C1orf43 mRNA, such as human C1orf43 mRNA, in a sample.Type: GrantFiled: November 15, 2018Date of Patent: July 5, 2022Assignee: Gen-Probe IncorporatedInventors: Siobhán M. Miick, Paul M. Darby, Jo Ann Jackson, Damon Kittredge Getman
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Publication number: 20220187331Abstract: After disposable pipette tips are used by an automated pipettor, they are released by the pipettor and fall into a waste container. When the waste container is removed to be emptied, the pipette tips are temporarily sequestered in a pipette tip holding station so that the automated pipettor may operate uninterrupted. After the waste container is replaced, the sequestered pipette tips are released by the holding station into the waste container.Type: ApplicationFiled: March 19, 2020Publication date: June 16, 2022Applicant: Gen-Probe IncorporatedInventors: David H. COMBS, Norbert D. HAGEN, Ayra BAKER, Joseph Reed ELLIS
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Publication number: 20220187016Abstract: A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest includes a base and first and second covers and is configured to support one or more receptacles each supporting one or more substances within interior spaces of the lyophilization nest. The interior spaces may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through the first and second covers. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior spaces when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.Type: ApplicationFiled: March 3, 2022Publication date: June 16, 2022Applicant: Gen-Probe IncorporatedInventor: Byron J. KNIGHT
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Patent number: 11359252Abstract: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.Type: GrantFiled: February 10, 2020Date of Patent: June 14, 2022Assignee: GEN-PROBE INCORPORATEDInventors: Sylvia A. Norman, Jennifer J. Bungo, William L. Hanna, Neeraj P. Rao
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Patent number: 11345946Abstract: A fluid container holder includes a body having a receptacle configured to receive a container. The body has a conductive outer surface for connection to an electrical ground or voltage source, and the holder is not formed solely of an electrically conductive metal. A fluid container handling assembly includes a drawer having a holder supporting a fluid container, and a frame supporting the holder. The frame is movable between a first position providing access to the holder and a second position positioning the holder within the instrument. The assembly also includes a first lock securing the holder to the frame when the frame is at the first frame position and unlocking the holder from the frame when the frame is at the second frame position. The assembly also includes a holder transporter configured to move the holder between a first holder position and a second holder position within the instrument.Type: GrantFiled: March 23, 2018Date of Patent: May 31, 2022Assignee: GEN-PROBE INCORPORATEDInventors: David Opalsky, David Buse, James T. Tuggle, Alexander Navarro, Patrick Sheehan
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Publication number: 20220162677Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.Type: ApplicationFiled: February 10, 2022Publication date: May 26, 2022Applicant: Gen-Probe IncorporatedInventors: David A. Buse, David Howard Combs, Byron J. Knight, Norbert D. Hagen, David Opalsky, Jason F. Rhubottom, Keith Moravick, Tyler Moore, Anita Prasad, Bruce Richardson
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Publication number: 20220162679Abstract: The invention provides compositions and methods for making closed nucleic acid structures in which one or both strands are continuous. The closed nucleic acid structures can be used as sequencing templates among other applications.Type: ApplicationFiled: December 2, 2021Publication date: May 26, 2022Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Jijumon CHELLISERRY
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Patent number: D954995Type: GrantFiled: July 20, 2021Date of Patent: June 14, 2022Assignee: GEN-PROBE INCORPORATEDInventor: Rolf Silbert
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Patent number: D958400Type: GrantFiled: September 23, 2020Date of Patent: July 19, 2022Assignee: GEN-PROBE INCORPORATEDInventor: Byron J. Knight