Patents Assigned to Genapsys, Inc.
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Patent number: 9926596Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: May 29, 2012Date of Patent: March 27, 2018Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Publication number: 20180051332Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: ApplicationFiled: May 29, 2012Publication date: February 22, 2018Applicant: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 9822401Abstract: The disclosure provides methods and systems for nucleic acid amplification including isothermal nucleic acid amplification.Type: GrantFiled: April 16, 2015Date of Patent: November 21, 2017Assignee: GENAPSYS, INC.Inventor: Florian Oberstrass
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Patent number: 9809852Abstract: Provided herein are devices and methods suitable for sequencing, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other biomolecules.Type: GrantFiled: March 14, 2014Date of Patent: November 7, 2017Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Hamid Rategh, Meysam R. Barmi, Kosar B. Parizi, Kambiz Kaviani
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Patent number: 9630177Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.Type: GrantFiled: March 12, 2015Date of Patent: April 25, 2017Assignee: GenapSys, Inc.Inventors: Seth Stern, Hesaam Esfandyarpour, David Eberhart
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Patent number: 9533305Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.Type: GrantFiled: August 25, 2015Date of Patent: January 3, 2017Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Mark Oldham
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Publication number: 20160273032Abstract: Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.Type: ApplicationFiled: December 10, 2014Publication date: September 22, 2016Applicant: GENAPSYS, INC.Inventors: Hesaam ESFANDYARPOUR, Meysam R. BARMI, Kosar B. PARIZI, Saurabh PALIWAL, Amirhossein SAMAKAR, Seth STERN
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Patent number: 9399217Abstract: Aspects of the invention include methods for improving the accuracy and read length of sequencing reactions by utilizing unlabeled unincorporable nucleotides, or by rephasing colony based sequencing reactions. Other aspects include systems and devices for improved measurement of biological reactions associated with bead which may be removed, utilizing current measurement methods through the counter ions associated with said beads due to the presence of reactants bound or associated with said bead, wherein electrodes for generating and measuring said current may be within the Debye length of said bead. Other aspects of the invention include methods for determining concentrations of input samples, means for reuse of an array, methods and apparatus for separating beads with different charge levels from each other.Type: GrantFiled: May 27, 2012Date of Patent: July 26, 2016Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar B. Parizi, Mark F. Oldham
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Patent number: 9274077Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: March 15, 2013Date of Patent: March 1, 2016Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 9187783Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.Type: GrantFiled: October 4, 2011Date of Patent: November 17, 2015Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Mark F. Oldham, Eric S. Nordman, Kosar Baghbani Parizi
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Patent number: 9150915Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.Type: GrantFiled: January 13, 2015Date of Patent: October 6, 2015Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Mark Oldham
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Patent number: 8969002Abstract: The present invention provides for methods and systems for Electronic DNA sequencing, single molecule DNA sequencing, and combinations of the above, providing low cost and convenient sequencing.Type: GrantFiled: October 1, 2012Date of Patent: March 3, 2015Assignee: Genapsys, Inc.Inventors: Hesaam Esfandyarpour, Mark Oldham
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Publication number: 20140235457Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: ApplicationFiled: May 29, 2012Publication date: August 21, 2014Applicant: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parazi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Publication number: 20140057339Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: ApplicationFiled: March 15, 2013Publication date: February 27, 2014Applicant: GENAPSYS INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parazi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Publication number: 20140045701Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.Type: ApplicationFiled: October 4, 2011Publication date: February 13, 2014Applicant: GENAPSYS INC.Inventors: Hesaam Esfandyarpour, Mark F. Oldham, Kosar Parazi, Eric Nordman
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Publication number: 20130096013Abstract: The present invention provides for methods and systems for Electronic DNA sequencing, single molecule DNA sequencing, and combinations of the above, providing low cost and convenient sequencing.Type: ApplicationFiled: October 1, 2012Publication date: April 18, 2013Applicant: Genapsys, Inc.Inventors: Hesaam Esfandyarpour, Mark Oldham, Eric Nordman