Patents Assigned to Genentech
  • Crystal structures and methods using same
    Publication number: 20100291114
    Abstract: The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns modulators of FGFR3 function, and the identification and uses of said modulators.
    Type: Application
    Filed: March 24, 2010
    Publication date: November 18, 2010
    Applicant: Genentech, Inc.
    Inventor: Christian Wiesmann
  • ANTI-DLL4 ANTIBODIES AND METHODS USING SAME
    Publication number: 20100292312
    Abstract: The invention provides anti-DLL4 antibodies, and compositions comprising and methods of using these antibodies.
    Type: Application
    Filed: August 2, 2010
    Publication date: November 18, 2010
    Applicant: Genentech, Inc.
    Inventors: Minhong Yan, Yan Wu
  • Anti-ROBO4 antibodies and uses therefor
    Patent number: 7834154
    Abstract: The invention provides anti-Robo4 antibodies, and compositions comprising the antibodies and methods of using these antibodies, including diagnostic and therapeutic methods.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: November 16, 2010
    Assignee: Genentech, Inc.
    Inventors: Alexander W. Koch, Scott Stawicki, Yan Wu, Richard Carano, Franklin V. Peale, Jr., Ryan J. Watts
  • HUMANIZED ANTI-EGFL7 ANTIBODIES AND METHODS USING SAME
    Publication number: 20100285009
    Abstract: The present invention concerns antibodies to EGFL7 and the uses of same.
    Type: Application
    Filed: May 7, 2010
    Publication date: November 11, 2010
    Applicant: Genentech, Inc.
    Inventors: Weilan Ye, Mark Dennis, Jill Fredrickson
  • Catheter composition and uses thereof
    Patent number: 7829082
    Abstract: A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise a chelating agent.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: November 9, 2010
    Assignee: Genentech, Inc.
    Inventor: Charles P. Semba
  • Methods for producing soluble membrane-spanning proteins
    Patent number: 7829684
    Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: November 9, 2010
    Assignee: Genentech, Inc.
    Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim
  • POLYPEPTIDES THAT BIND BR3 AND USES THEREOF
    Publication number: 20100280227
    Abstract: The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
    Type: Application
    Filed: July 13, 2010
    Publication date: November 4, 2010
    Applicant: GENENTECH, INC.
    Inventors: CHRISTINE M. AMBROSE, MERCEDESZ BALAZS, LAURA DEFORGE, MARK S. DENNIS, GERMAINE FUH, STEPHEN D. HURST, CHINGWEI V. LEE, HENRY B. LOWMAN, FLAVIUS MARTIN, GERALD R. NAKAMURA, DHAYA SESHASAYEE, MELISSA A. STAROVASNIK, JEFFREY S. THOMPSON
  • ANTI-EPHB2 ANTIBODIES AND METHODS USING SAME
    Publication number: 20100278842
    Abstract: The invention provides anti-EphB2 antibodies, immunoconjugates, and compositions comprising and methods of using these antibodies and immunoconjugates.
    Type: Application
    Filed: June 8, 2010
    Publication date: November 4, 2010
    Applicant: Genentech, Inc.
    Inventors: Weiguang Mao, Paul Polakis
  • Methods and Compositions For Detecting Autoimmune Disorders
    Publication number: 20100279298
    Abstract: The invention provides methods and compositions useful for detecting autoimmune disorders.
    Type: Application
    Filed: March 30, 2010
    Publication date: November 4, 2010
    Applicant: Genentech, Inc.
    Inventor: Alexander Abbas
  • Antibodies that bind hepatocyte growth factor activator
    Patent number: 7825221
    Abstract: The invention provides methods and compositions for modulating hepatocyte growth factor activator function.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: November 2, 2010
    Assignee: Genentech, Inc.
    Inventors: Daniel K. Kirchhofer, Yan Wu
  • Delivery of proteins across polar epithelial cell layers
    Patent number: 7824695
    Abstract: This invention provides bioactive conjugates. The bioactive conjugates include: (1) a cell recognition moiety that binds to ?2 macroglobulin receptor ?2-MR and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as an immunogen to invoke an immune response and (c) does not have ADP ribosylating activity. The bioactive conjugates of this invention are useful in methods of transporting the bioactive moiety across a polar epithelial membrane. Thus, this invention provides methods for parenteral administration of proteins without injection.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: November 2, 2010
    Assignees: The United States of America as represented by the Department of Health and Human Services, Genentech, Inc.
    Inventors: David J. FitzGerald, Randall J. Mrsny, Marian McKee, Ann Daugherty
  • Method for using antibodies for inhibiting blood coagulation
    Patent number: 7824677
    Abstract: The invention includes methods of inhibiting blood coagulation using antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Methods of the invention can effectively inhibit blood coagulation in vivo. Antibodies used in the methods of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies used in the methods of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
    Type: Grant
    Filed: June 10, 2008
    Date of Patent: November 2, 2010
    Assignee: Genentech, Inc.
    Inventors: Hing C. Wong, Jin-An Jiao, Esperanza Liliana Nieves, Lawrence Luepschen
  • Erodible polymers for injection
    Patent number: 7824700
    Abstract: A composition for administration of a beneficial agent, contains a solvent mixture including a hydrophobic solvent and a hydrophilic solvent; a bioerodible polymer; and a beneficial agent. The polymer and the beneficial agent are dissolved. The composition has a low viscosity, allowing for easy injection through standard hypodermic needles.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: November 2, 2010
    Assignee: Genentech, Inc.
    Inventors: Jeffrey L. Cleland, Franklin Okumu
  • Apo-2DcR
    Publication number: 20100273257
    Abstract: Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
    Type: Application
    Filed: January 15, 2009
    Publication date: October 28, 2010
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, Anan Chuntharapai, Austin Gurney, Kyung Jin Kim, William I. Wood
  • ANTI-OX40L ANTIBODIES AND METHODS USING SAME
    Publication number: 20100272738
    Abstract: The invention provides anti-OX40L antibodies, and compositions comprising and methods of using these antibodies.
    Type: Application
    Filed: July 12, 2010
    Publication date: October 28, 2010
    Applicant: Genentech, Inc.
    Inventor: Flavius Martin
  • Methods for producing soluble membrane spanning proteins
    Patent number: 7820806
    Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: October 26, 2010
    Assignee: Genentech, Inc.
    Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim
  • Treatment of autoimmune diseases
    Patent number: 7820161
    Abstract: Methods are disclosed of treating rheumatoid arthritis in a human comprising administering to the human more than one intravenous dose of a therapeutically effective amount of rituximab and administering methotrexate to the human.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: October 26, 2010
    Assignees: Biogen Idec, Inc., Genentech, Inc.
    Inventors: John G. Curd, Lori A. Kunkel, Antonio J. Grillo-Lopez
  • METHODS AND COMPOSITIONS FOR TARGETING POLYUBIQUITIN
    Publication number: 20100267050
    Abstract: Anti-polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
    Type: Application
    Filed: April 23, 2010
    Publication date: October 21, 2010
    Applicant: Genentech, Inc.
    Inventors: Nathaniel C. Gordon, Robert F. Kelley, Anh Pham
  • WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS
    Publication number: 20100266593
    Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
    Type: Application
    Filed: June 29, 2010
    Publication date: October 21, 2010
    Applicant: Genentech, Inc.
    Inventors: James A. Ernst, Paul Polakis, Bonnee Rubinfeld, Venita I. DeAlmeida
  • Polynucleotide overexpressed in tumors
    Patent number: RE41888
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: October 26, 2010
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood