Patents Assigned to Genentech
  • Anti-cmet antibodies
    Patent number: 7892550
    Abstract: The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: February 22, 2011
    Assignee: Genentech, Inc.
    Inventors: Mark S. Dennis, Karen Billeci, Judy Young, Zhong Zheng
  • COMPOSITIONS AND METHODS FOR ENHANCING APOPTOSIS
    Publication number: 20110039324
    Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: July 13, 2010
    Publication date: February 17, 2011
    Applicant: Genentech, Inc.
    Inventors: Kurt Deshayes, Wayne Fairbrother, John Flygare, Matthew C. Franklin, Saloumeh Fischer, Domagoj Vucic
  • Phosphoinositide 3-kinase inhibitor compounds and methods of use
    Patent number: 7888352
    Abstract: Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: February 15, 2011
    Assignees: Piramed Limited, Genentech, Inc.
    Inventors: Tracy Bayliss, Irina Chuckowree, Adrian Folkes, Sally Oxenford, Nan Chi Wan, Georgette Castanedo, Richard Goldsmith, Janet Gunzner, Tim Heffron, Simon Mathieu, Alan Olivero, Steven Staben, Daniel P. Sutherlin, Bing-Yan Zhu
  • Compositions and methods for the treatment of tumor of hematopoietic origin
    Patent number: 7888478
    Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: February 15, 2011
    Assignee: Genentech, Inc.
    Inventors: Wesley Chang, Frederic J. de Sauvage, Dan L. Eaton, Allen J. Ebens, Jr., Gretchen Frantz, Jo-Anne S. Hongo, Hartmut Koeppen, Andrew Polson, Victoria Smith
  • CRYSTAL STRUCTURE OF OX40L AND OX40L COMPLEXED WITH OX40 RECEPTOR
    Publication number: 20110028688
    Abstract: The present disclosure provides crystals of and structural coordinates of mOX40L, hOX40L, hOX40 receptor and complexes thereof. The crystals and crystal structures are useful, for example, in the design and synthesis of modulators of mOX40L, hOX40L, and/or hOX40 receptor.
    Type: Application
    Filed: June 19, 2007
    Publication date: February 3, 2011
    Applicant: GENENTECH, INC.
    Inventors: Sarah Hymowitz, Deanne Compaan McGuinn
  • BINDING POLYPEPTIDES WITH OPTIMIZED SCAFFOLDS
    Publication number: 20110028348
    Abstract: The invention provides variant heavy chain variable domains (VH) with increased folding stability. Libraries comprising a plurality of these polypeptides are also provided. In addition, compositions and methods of generating and using these polypeptides and libraries are provided.
    Type: Application
    Filed: October 15, 2010
    Publication date: February 3, 2011
    Applicant: GENENTECH, INC.
    Inventors: PIERRE A. BARTHELEMY, SACHDEV S. SIDHU
  • HER2 antibody composition
    Patent number: 7879325
    Abstract: A composition comprising a main species HER2 antibody that binds to domain II of HER2, and an amino acid sequence variant thereof comprising an amino-terminal leader extension is disclosed. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: February 1, 2011
    Assignee: Genentech, Inc.
    Inventors: Yung-Hsiang Kao, Martin Vanderlaan
  • ANTI-VEGF ANTIBODIES
    Publication number: 20110020346
    Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
    Type: Application
    Filed: July 27, 2010
    Publication date: January 27, 2011
    Applicant: Genentech, Inc.
    Inventors: Germaine Fuh, Hans-Peter Gerber, Wei-Ching Liang, Frederic A. Fellouse, Sachdev S. Sidhu, Christian Wiesmann
  • CRYSTALLIZATION OF ANTI-CD20 ANTIBODIES
    Publication number: 20110020322
    Abstract: The present invention relates generally to crystalline forms of anti-CD20 antibodies and purification of anti-CD20 antibodies involving crystallization.
    Type: Application
    Filed: June 17, 2010
    Publication date: January 27, 2011
    Applicant: Genentech, Inc.
    Inventors: James A. Wilkins, Shadia Abike Oshodi, Brian Lobo, Timothy Breece
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF GLUCOCORTICOID RECEPTOR (GCR) GENES
    Publication number: 20110020300
    Abstract: This invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a GCR gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a GCR gene using said pharmaceutical composition; and methods for inhibiting the expression of GCR in a cell.
    Type: Application
    Filed: May 14, 2010
    Publication date: January 27, 2011
    Applicant: GENENTECH, INC.
    Inventors: JACQUES BAILLY, AGNÈS BÉNARDEAU, BIRGIT BRAMLAGE, RAINER CONSTIEN, ANDREA FORST, MARKUS HOSSBACH, BRIGITTE SCHOTT
  • Methods for detecting inflammatory bowel disease
    Patent number: 7875431
    Abstract: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.
    Type: Grant
    Filed: February 22, 2008
    Date of Patent: January 25, 2011
    Assignee: Genentech, Inc.
    Inventors: Lauri Diehl, Kenneth Flanagan, Lian Mo
  • PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
    Publication number: 20110015204
    Abstract: The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
    Type: Application
    Filed: July 3, 2008
    Publication date: January 20, 2011
    Applicants: Array BioPharma, Inc., Genentech, Inc.
    Inventors: Josef Bencsik, James F. Blake, James M. Graham, Martin F. Hentemann, Nicholas C. Kallan, Ian S. Mitchell, Stephen T. Schlachter, Keith L. Spencer, Dengming Xiao, Rui Xu, Mike Welch, Jun Liang, Brian S. Safina
  • CRYSTAL STRUCTURE OF THE COMPLEX OF HEPATOCYTE GROWTH FACTOR BETA CHAIN WITH MET RECEPTOR AND METHODS OF USE
    Publication number: 20110012894
    Abstract: The disclosure provides a crystal structure of a complex of the HGF ?-chain with am extracellular fragment of the Met receptor, as well as use of the crystal structure in the design, identification, and selection of ligands that modulate the Met Receptor and the interaction of HGF with the Met receptor.
    Type: Application
    Filed: May 20, 2010
    Publication date: January 20, 2011
    Applicant: Genentech, Inc.
    Inventors: Christian Wiesmann, Jennifer Stamos
  • ANTI-VEGF ANTIBODIES
    Publication number: 20110014198
    Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
    Type: Application
    Filed: June 15, 2010
    Publication date: January 20, 2011
    Applicant: Genentech, Inc.
    Inventors: Germaine Fuh, Hans-Peter Gerber, Wei-Ching Liang, Frederic A. Fellouse, Sachdev S. Sidhu, Christian Wiesmann
  • Treatment of Autoimmune Diseases
    Publication number: 20110008250
    Abstract: The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
    Type: Application
    Filed: September 20, 2010
    Publication date: January 13, 2011
    Applicant: Genentech, Inc.
    Inventors: John G. Curd, Lori A. Kunkel, Antonio J. Grillo-Lopez
  • APO-2 RECEPTOR POLYPEPTIDES
    Publication number: 20110009599
    Abstract: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
    Type: Application
    Filed: March 1, 2010
    Publication date: January 13, 2011
    Applicant: Genentech, Inc.
    Inventor: Avi J. Ashkenazi
  • ANTIBODIES TO APO-2 RECEPTOR POLYPEPTIDES
    Publication number: 20110008354
    Abstract: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
    Type: Application
    Filed: August 19, 2010
    Publication date: January 13, 2011
    Applicant: GENENTECH, INC.
    Inventors: CAMELLIA W. ADAMS, AVI J. ASHKENAZI, ANAN CHUNTHARAPAI, KYUNG JIN KIM
  • Treatment of Autoimmune Diseases
    Publication number: 20110008338
    Abstract: The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
    Type: Application
    Filed: September 20, 2010
    Publication date: January 13, 2011
    Applicant: Genentech, Inc.
    Inventors: John G. Curd, Lori A. Kunkel, Antonio J. Grillo-Lopez
  • Treatment of Autoimmune Diseases
    Publication number: 20110008336
    Abstract: The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
    Type: Application
    Filed: September 20, 2010
    Publication date: January 13, 2011
    Applicant: Genentech, Inc.
    Inventors: John G. Curd, Lori A. Kunkel, Antonio J. Grillo-Lopez
  • Anti-PRO87299 antibodies
    Patent number: 7863422
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: January 4, 2011
    Assignee: Genentech, Inc.
    Inventors: Hilary Clark, Daniel L. Eaton, Bernd Wranik, Wenjun Ouyang, Lino Gonzalez, Austin L. Gurney, Kelly Loyet