Patents Assigned to Genentech
  • Methods of stimulating ErbB4 receptor phosphorylation
    Patent number: 7846453
    Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: December 7, 2010
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Melanie Rose Mark, Dong Xiao Zhang
  • Phosphoinositide 3-kinase inhibitor compounds and methods of use
    Patent number: 7846929
    Abstract: Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: December 7, 2010
    Assignees: Genentech, Inc., Piramed Limited
    Inventors: Adrian Folkes, Stephen Shuttleworth, Sally Oxenford, Tim Hancox, Tracy Bayliss, Georgette Castanedo, Richard Goldsmith, Janet Gunzner, Tim Heffron, Kimberly Malesky, Simon Mathieu, Alan Olivero, Daniel P. Sutherlin, Vickie Tsui, Shumei Wang, Christian Wiesmann, Bing-Yan Zhu, Jennafer Dotson
  • Polynucleotide encoding an anti-FGF19 antibody
    Patent number: 7846691
    Abstract: The invention provides anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: December 7, 2010
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Dorothy French
  • METHOD FOR TREATING LUPUS
    Publication number: 20100303810
    Abstract: A method of treating lupus in a subject eligible for treatment is provided involving administering an effective amount of an antibody that binds to a B-cell surface marker to the subject to provide an initial exposure and a subsequent exposure to the antibody within certain dosing regimens and an article of manufacture therefor.
    Type: Application
    Filed: July 23, 2010
    Publication date: December 2, 2010
    Applicant: GENENTECH, INC.
    Inventor: PAUL G. BRUNETTA
  • Antibody fragment-polymer conjugates and uses of same
    Patent number: 7842789
    Abstract: Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment. Also described are conjugates directed against human vascular endothelial growth factor (VEGF), human p185 receptor-like tyrosine kinase (HER2), human CD20, human CD18, human CD11a, human IgE, human apoptosis receptor-2 (Apo-2), human tumor necrosis factor-? (TNF-?), human tissue factor (TF), human ?4?7 integrin, human GPIIb-IIIa integrin, human epidermal growth factor receptor (EGFR), human CD3, and human interleukin-2 receptor ?-chain (TAC) for diagnostic and therapeutic applications.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: November 30, 2010
    Assignee: Genentech, Inc.
    Inventors: Vanessa Hsei, Iphigenia Koumenis, Steven Leong, Zahra Shahrokh, Gerardo Zapata
  • Apo-2 ligand/trail formulations
    Patent number: 7842668
    Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: November 30, 2010
    Assignee: Genentech, Inc.
    Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh
  • ANTI-DLL4 ANTIBODIES AND METHODS USING SAME
    Publication number: 20100292312
    Abstract: The invention provides anti-DLL4 antibodies, and compositions comprising and methods of using these antibodies.
    Type: Application
    Filed: August 2, 2010
    Publication date: November 18, 2010
    Applicant: Genentech, Inc.
    Inventors: Minhong Yan, Yan Wu
  • Crystal structures and methods using same
    Publication number: 20100291114
    Abstract: The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns modulators of FGFR3 function, and the identification and uses of said modulators.
    Type: Application
    Filed: March 24, 2010
    Publication date: November 18, 2010
    Applicant: Genentech, Inc.
    Inventor: Christian Wiesmann
  • Anti-ROBO4 antibodies and uses therefor
    Patent number: 7834154
    Abstract: The invention provides anti-Robo4 antibodies, and compositions comprising the antibodies and methods of using these antibodies, including diagnostic and therapeutic methods.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: November 16, 2010
    Assignee: Genentech, Inc.
    Inventors: Alexander W. Koch, Scott Stawicki, Yan Wu, Richard Carano, Franklin V. Peale, Jr., Ryan J. Watts
  • HUMANIZED ANTI-EGFL7 ANTIBODIES AND METHODS USING SAME
    Publication number: 20100285009
    Abstract: The present invention concerns antibodies to EGFL7 and the uses of same.
    Type: Application
    Filed: May 7, 2010
    Publication date: November 11, 2010
    Applicant: Genentech, Inc.
    Inventors: Weilan Ye, Mark Dennis, Jill Fredrickson
  • Methods for producing soluble membrane-spanning proteins
    Patent number: 7829684
    Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: November 9, 2010
    Assignee: Genentech, Inc.
    Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim
  • Catheter composition and uses thereof
    Patent number: 7829082
    Abstract: A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise a chelating agent.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: November 9, 2010
    Assignee: Genentech, Inc.
    Inventor: Charles P. Semba
  • ANTI-EPHB2 ANTIBODIES AND METHODS USING SAME
    Publication number: 20100278842
    Abstract: The invention provides anti-EphB2 antibodies, immunoconjugates, and compositions comprising and methods of using these antibodies and immunoconjugates.
    Type: Application
    Filed: June 8, 2010
    Publication date: November 4, 2010
    Applicant: Genentech, Inc.
    Inventors: Weiguang Mao, Paul Polakis
  • POLYPEPTIDES THAT BIND BR3 AND USES THEREOF
    Publication number: 20100280227
    Abstract: The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
    Type: Application
    Filed: July 13, 2010
    Publication date: November 4, 2010
    Applicant: GENENTECH, INC.
    Inventors: CHRISTINE M. AMBROSE, MERCEDESZ BALAZS, LAURA DEFORGE, MARK S. DENNIS, GERMAINE FUH, STEPHEN D. HURST, CHINGWEI V. LEE, HENRY B. LOWMAN, FLAVIUS MARTIN, GERALD R. NAKAMURA, DHAYA SESHASAYEE, MELISSA A. STAROVASNIK, JEFFREY S. THOMPSON
  • Methods and Compositions For Detecting Autoimmune Disorders
    Publication number: 20100279298
    Abstract: The invention provides methods and compositions useful for detecting autoimmune disorders.
    Type: Application
    Filed: March 30, 2010
    Publication date: November 4, 2010
    Applicant: Genentech, Inc.
    Inventor: Alexander Abbas
  • Antibodies that bind hepatocyte growth factor activator
    Patent number: 7825221
    Abstract: The invention provides methods and compositions for modulating hepatocyte growth factor activator function.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: November 2, 2010
    Assignee: Genentech, Inc.
    Inventors: Daniel K. Kirchhofer, Yan Wu
  • Method for using antibodies for inhibiting blood coagulation
    Patent number: 7824677
    Abstract: The invention includes methods of inhibiting blood coagulation using antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Methods of the invention can effectively inhibit blood coagulation in vivo. Antibodies used in the methods of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies used in the methods of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
    Type: Grant
    Filed: June 10, 2008
    Date of Patent: November 2, 2010
    Assignee: Genentech, Inc.
    Inventors: Hing C. Wong, Jin-An Jiao, Esperanza Liliana Nieves, Lawrence Luepschen
  • Delivery of proteins across polar epithelial cell layers
    Patent number: 7824695
    Abstract: This invention provides bioactive conjugates. The bioactive conjugates include: (1) a cell recognition moiety that binds to ?2 macroglobulin receptor ?2-MR and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as an immunogen to invoke an immune response and (c) does not have ADP ribosylating activity. The bioactive conjugates of this invention are useful in methods of transporting the bioactive moiety across a polar epithelial membrane. Thus, this invention provides methods for parenteral administration of proteins without injection.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: November 2, 2010
    Assignees: The United States of America as represented by the Department of Health and Human Services, Genentech, Inc.
    Inventors: David J. FitzGerald, Randall J. Mrsny, Marian McKee, Ann Daugherty
  • Erodible polymers for injection
    Patent number: 7824700
    Abstract: A composition for administration of a beneficial agent, contains a solvent mixture including a hydrophobic solvent and a hydrophilic solvent; a bioerodible polymer; and a beneficial agent. The polymer and the beneficial agent are dissolved. The composition has a low viscosity, allowing for easy injection through standard hypodermic needles.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: November 2, 2010
    Assignee: Genentech, Inc.
    Inventors: Jeffrey L. Cleland, Franklin Okumu
  • ANTI-OX40L ANTIBODIES AND METHODS USING SAME
    Publication number: 20100272738
    Abstract: The invention provides anti-OX40L antibodies, and compositions comprising and methods of using these antibodies.
    Type: Application
    Filed: July 12, 2010
    Publication date: October 28, 2010
    Applicant: Genentech, Inc.
    Inventor: Flavius Martin