Patents Assigned to Genentech
  • Antibodies to PRO352
    Patent number: 7786272
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: August 31, 2010
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Polypeptide variants with altered effector function
    Patent number: 7785791
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: August 31, 2010
    Assignee: Genentech, Inc.
    Inventor: Leonard Presta
  • METHODS AND COMPOSITIONS FOR DIAGNOSTIC USE IN CANCER PATIENTS
    Publication number: 20100216115
    Abstract: Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer.
    Type: Application
    Filed: December 22, 2009
    Publication date: August 26, 2010
    Applicant: Genentech, Inc.
    Inventors: Yibing Yan, Paul J. Fielder, Qun Jenny Wu
  • ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE
    Publication number: 20100215669
    Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: January 14, 2009
    Publication date: August 26, 2010
    Applicant: Genentech, Inc.
    Inventors: Yvonne CHEN, Mark Dennis, David Dornan, Kristi Elkins, Jagath Reddy Junutula, Andrew Polson
  • HGF BETA CHAIN VARIANTS
    Publication number: 20100210826
    Abstract: The invention provides HGF/Met modulators comprising HGF having mutations in regions that affect HGF function, and antagonists that target said regions. The invention further provides methods of identifying, making and using these modulators.
    Type: Application
    Filed: April 27, 2010
    Publication date: August 19, 2010
    Applicant: Genentech, Inc.
    Inventors: Daniel K. Kirchhofer, Robert A. Lazarus, Christian Wiesmann
  • METHODS AND COMPOSITIONS FOR MODULATING HEPATOCYTE GROWTH FACTOR ACTIVATION
    Publication number: 20100209956
    Abstract: The invention provides methods and compositions for modulating hepsin activity and the HGF/c-met signaling pathway, in particular by regulating pro-HGF activation by hepsin.
    Type: Application
    Filed: March 10, 2010
    Publication date: August 19, 2010
    Applicant: Genentech, Inc.
    Inventors: Daniel K. Kirchhofer, Paul M. Moran, Mark D. Peek
  • PRO9907 antibodies
    Patent number: 7777007
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: August 17, 2010
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Luc Desnoyers, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Victoria Smith, Jean-Philippe F. Stephan, Colin K. Watanabe, William I. Wood
  • Crystal structure of CRIg and C3b:CRIg complex
    Patent number: 7776573
    Abstract: The present invention concerns determination of the crystal structure of the macrophage specific receptor, CRIg (earlier referred to as STIgMA), and its complex with the C3b and C3c subunits of complement C3 (C3b:CRIg and C3c:CRIg complexes). The invention further concerns the use of the crystal structure of CRIg or the C3b:CRIg complex to screen for and identify molecules structurally and/or functionally related to CRIg, including CRIg agonists and antagonists.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: August 17, 2010
    Assignee: Genentech, Inc.
    Inventors: Philip Hass, Jianping Yin, Kenneth Katschke, Micah Steffek, Menno Van Lookeren Campagne, Christian Wiesmann
  • ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION
    Publication number: 20100203056
    Abstract: The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
    Type: Application
    Filed: December 8, 2009
    Publication date: August 12, 2010
    Applicant: Genentech, Inc.
    Inventors: Bryan Irving, Henry Chiu, Heather Maecker, Sanjeev Mariathasan, Sophie M. Lehar, Yan Wu, Jeanne Cheung
  • ANTIBODIES TO EGFL7 AND METHODS FOR THEIR USE
    Publication number: 20100203041
    Abstract: The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.
    Type: Application
    Filed: March 16, 2007
    Publication date: August 12, 2010
    Applicant: Genentech , Inc.
    Inventors: Weilan Ye, Maike Schmidt, Jo-Anne Hongo, Yan Wu
  • Methods for using chimeric vascular endothelial growth factor receptor proteins
    Patent number: 7771721
    Abstract: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and anglogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: August 10, 2010
    Assignee: Genentech, Inc.
    Inventors: Terri Lynn Davis-Smyth, Helen Hsifei Chen, Leonard Presta, Napoleone Ferrara
  • Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E
    Patent number: 7771719
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: August 10, 2010
    Assignee: Genentech, Inc.
    Inventors: Ellen H. Filvaroff, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Anti-EphB2 antibodies and methods using same
    Patent number: 7767205
    Abstract: The invention provides anti-EphB2 antibodies, immunoconjugates, and compositions comprising and methods of using these antibodies and immunoconjugates.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: August 3, 2010
    Assignee: Genentech, Inc.
    Inventors: Weiguang Mao, Paul Polakis
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 7767403
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: August 3, 2010
    Assignee: Genentech, Inc.
    Inventors: Gretchen Frantz, Paul Polakis, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • ANTI-VEGF ANTIBODIES
    Publication number: 20100189719
    Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
    Type: Application
    Filed: February 4, 2010
    Publication date: July 29, 2010
    Applicant: Genentech, Inc.
    Inventors: Germaine Fuh, Hans-Peter Gerber, Wei-Ching Liang, Frederic A. Fellouse, Sachdev S. Sidhu, Christian Wiesmann
  • METHODS FOR THE DETECTION OF FATTY-ACYLATED PROTEIN
    Publication number: 20100189660
    Abstract: Sensitive, non-radioactive fatty-acyls of Formula I are useful in in vivo methods for detection and cellular imaging of a fatty-acylated substrate (e.g., protein or polypeptide). In Formula I the symbols X and A, and the subscript n are as described herein. These fatty-acyl compounds are can be used, inter alia, for analyzing the lipid composition of proteins in different biological states under various cellular conditions, and serve as a gateway into global lipidomic analysis of cellular proteins.
    Type: Application
    Filed: February 12, 2010
    Publication date: July 29, 2010
    Applicant: Genentech, Inc.
    Inventor: Rami N. Hannoush
  • Methods and compositions for targeting polyubiquitin
    Patent number: 7763245
    Abstract: Anti-polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: July 27, 2010
    Assignee: Genentech, Inc.
    Inventors: Nathaniel C. Gordon, Robert F. Kelley, Anh Pham
  • Anti-VEGF antibodies
    Patent number: 7758859
    Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: July 20, 2010
    Assignee: Genentech, Inc.
    Inventors: Germaine Fuh, Hans-Peter Gerber, Wei-Ching Liang, Frederic A. Fellouse, Sachdev S. Sidhu, Christian Wiesmann
  • Crystal structure of the complex of hepatocyte growth factor beta chain with met receptor and methods of use
    Patent number: 7754458
    Abstract: The disclosure provides a crystal structure of a complex of the HGF ?-chain with am extracellular fragment of the Met receptor, as well as use of the crystal structure in the design, identification, and selection of ligands that modulate the Met Receptor and the interaction of HGF with the Met receptor.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: July 13, 2010
    Assignee: Genentech, Inc.
    Inventors: Christian Wiesmann, Jennifer Stamos
  • Compositions and methods for the treatment of tumor of hematopoietic origin
    Patent number: 7754441
    Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: July 13, 2010
    Assignee: Genentech, Inc.
    Inventors: Frederic J. de Sauvage, Dan L. Eaton, Allen J. Ebens, Jr., Andrew Polson, Victoria Smith, Suzie J. Scales