Patents Assigned to Genentech
  • PRO9822 polypeptides
    Patent number: 7449549
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: November 11, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • POLYPEPTIDE VARIANTS WITH ALTERED EFFECTOR FUNCTION
    Publication number: 20080274506
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Application
    Filed: February 19, 2008
    Publication date: November 6, 2008
    Applicant: Genentech, Inc.
    Inventor: LEONARD PRESTA
  • POLYPEPTIDE VARIANTS WITH ALTERED EFFECTOR FUNCTION
    Publication number: 20080274105
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Application
    Filed: November 16, 2007
    Publication date: November 6, 2008
    Applicant: Genentech, Inc.
    Inventor: LEONARD PRESTA
  • POLYPEPTIDE VARIANTS WITH ALTERED EFFECTOR FUNCTION
    Publication number: 20080274108
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Application
    Filed: July 11, 2008
    Publication date: November 6, 2008
    Applicant: Genentech, Inc.
    Inventor: LEONARD PRESTA
  • Methods and compositions for modulating vascular integrity
    Publication number: 20080274993
    Abstract: The invention provides methods and compositions useful for modulating vascular integrity.
    Type: Application
    Filed: March 10, 2008
    Publication date: November 6, 2008
    Applicant: Genentech, Inc.
    Inventors: Hans-Peter Gerber, Boris A. Hesser
  • Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
    Patent number: 7445905
    Abstract: The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: November 4, 2008
    Assignee: Genentech, Inc.
    Inventors: Austin L. Gurney, Sudeepta Aggarwal, Ming-Hong Xie, Ellen M. Maruoka, Jessica S. Foster, Audrey Goddard, William I. Wood
  • EG-VEGF nucleic acids and polypeptides and methods of use
    Patent number: 7446168
    Abstract: The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: November 4, 2008
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Colin Watanabe, William I. Wood
  • TREATMENT WITH ANTI-VEGF ANTIBODIES
    Publication number: 20080267968
    Abstract: This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents.
    Type: Application
    Filed: July 14, 2008
    Publication date: October 30, 2008
    Applicant: Genentech, Inc.
    Inventors: Gwendolyn Fyfe, Eric Holmgren, Robert D. Mass, William Novotny
  • Bisamide Inhibitors of Hedgehog Signaling
    Publication number: 20080269215
    Abstract: The invention provides inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein ring A, ring B, R1, R2, R3, R4, R5, m and n are as defined herein.
    Type: Application
    Filed: November 14, 2006
    Publication date: October 30, 2008
    Applicant: GENENTECH INC.
    Inventors: Richard A. Goldsmith, Daniel P. Sutherlin, Kirk D. Robarge, Alan G. Olivero
  • Secreted transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7442765
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: October 28, 2008
    Assignee: GENENTECH, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • Antibodies to PRO361 polypeptide
    Patent number: 7442772
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: October 28, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Daniel Tumas, William I. Wood
  • Detecting and Quantifying Host Cell Proteins in Recombinant Protein Products
    Publication number: 20080261249
    Abstract: A single-step immunoassay method, kit, and reagents for detecting and quantifying contaminant host cell proteins in a recombinant protein sample are described. The method includes the step of adding to immobilized medium comprising a capture reagent including anti-host cell protein antibodies, both the recombinant protein sample and a detection reagent comprising anti-host cell protein antibodies and a detectable moeity. The recombinant protein sample and two reagents are added simultaneously. This single-step format provides greater interaction between the capture antibody, the contaminant host cell proteins that may be present in the recombinant protein sample, and the detection antibody. By providing the opportunity for both antibodies and HCPs to interact at the same time, the one step format allows the formation of the “capture antibody-HCP-detection antibody” complex with all possible HCPs present.
    Type: Application
    Filed: January 7, 2005
    Publication date: October 23, 2008
    Applicant: Genentech, Inc
    Inventors: Yajun "Jennifer" Wang, Meng-Yuan "Patrick" Liu
  • Inhibition of complement activation
    Patent number: 7439331
    Abstract: The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab?)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: October 21, 2008
    Assignee: Genentech, Inc.
    Inventors: Michael S. C. Fung, William N. C. Sun, Cecily R. Y. Sun
  • PRO6001 polypeptides
    Patent number: 7439325
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: October 21, 2008
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • ANTI-EPHB2 ANTIBODIES AND METHODS USING SAME
    Publication number: 20080254024
    Abstract: The invention provides anti-EphB2 antibodies, immunoconjugates, and compositions comprising and methods of using these antibodies and immunoconjugates.
    Type: Application
    Filed: July 31, 2007
    Publication date: October 16, 2008
    Applicant: Genentech, Inc.
    Inventors: Weiguang Mao, Paul Polakis
  • Anti-tissue factor antibodies with enhanced anticoagulant potency
    Patent number: 7435413
    Abstract: The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to comprise a region binding to an epitope in the C-terminal macromolecular substrate binding region of TF.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: October 14, 2008
    Assignee: Genentech, Inc.
    Inventors: Daniel K. Kirchhofer, David G. Lowe, Leonard G. Presta
  • Antibodies to a polypeptide encoded by a nucleic acid overexpressed in normal stomach, normal skin and kidney tumor
    Patent number: 7435798
    Abstract: The present invention is directed to novel antibodies that bind to novel polypeptides encoded by nucleic acids that are differentially expressed in kidney, stomach, and melanoma tumors.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: October 14, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • Anti-HER2 antibody variants
    Patent number: 7435797
    Abstract: The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: October 14, 2008
    Assignee: Genentech, Inc.
    Inventors: Henry B. Lowman, Resi B. Gerstner, Paul J. Carter
  • Peptides that induce chondrocyte redifferentiation
    Patent number: 7435793
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: October 14, 2008
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • ANTI-ROBO4 ANTIBODIES AND USES THEREFOR
    Publication number: 20080247951
    Abstract: The invention provides anti-Robo4 antibodies, and compositions comprising the antibodies and methods of using these antibodies, including diagnostic and therapeutic methods.
    Type: Application
    Filed: February 8, 2008
    Publication date: October 9, 2008
    Applicant: Genentech, Inc.
    Inventors: Alexander W. Koch, Scott Stawicki, Yan Wu, Richard Carano, Franklin V. Peale, Ryan J. Watts