Patents Assigned to Genentech
  • Treatment and Diagnosis of Insulin-Resistant States
    Publication number: 20060293239
    Abstract: Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity. Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing antibodies to Dkk-5 and preparations comprising Dkk-5.
    Type: Application
    Filed: August 21, 2006
    Publication date: December 28, 2006
    Applicant: Genentech, Inc.
    Inventors: Venita DeAlmeida, Timothy Stewart
  • Use of heregulin as a growth factor
    Patent number: 7153828
    Abstract: Ligands which bind to the HER2, HER3 and/or HER4 receptors are useful as normal epithelial cell growth factors.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: December 26, 2006
    Assignees: Genentech, Inc., University of Iowa Research Foundation
    Inventors: Mark X. Sliwkowski, Jeffrey A. Kern
  • Nucleic acids encoding an immune related polypeptide
    Patent number: 7153950
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: December 26, 2006
    Assignee: Genentech, Inc.
    Inventors: Hilary Clark, Daniel L. Eaton, Austin L. Gurney, Bernd Wranik
  • Charged filtration membranes and uses therefor
    Patent number: 7153426
    Abstract: The invention relates to charged filtration membranes and their use for separation of a protein from solvent, low molecular weight solutes or a mixture of proteins. Modification of the membranes to generate charge includes modification of membrane pores to alter charge within a pore and alter the size of a pore. Consequently, the protein is separated from other solutes in a mixture based on size as well as net protein charge and membrane charge.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: December 26, 2006
    Assignee: Genentech, Inc.
    Inventor: Robert D. van Reis
  • PRO354 antibodies
    Patent number: 7153939
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: December 26, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Antibodies that bind PRO4994 polypeptides
    Patent number: 7153941
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: December 26, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Wound healing
    Publication number: 20060287234
    Abstract: Methods for accelerating and/or improving wound healing in a subject by administering vascular endothelial growth factor (VEGF) are provided.
    Type: Application
    Filed: June 16, 2006
    Publication date: December 21, 2006
    Applicant: Genentech, Inc.
    Inventors: Timothy Breen, Stuart Bunting, Charles Semba
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7151160
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: December 19, 2006
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Kenneth J. Hillan, William I. Wood
  • Anti-VEGF antibodies
    Publication number: 20060280747
    Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
    Type: Application
    Filed: January 27, 2006
    Publication date: December 14, 2006
    Applicant: Genentech, Inc.
    Inventors: Germaine Fuh, Hans-Peter Gerber, Wei-Ching Liang, Frederic Fellouse, Sachdev Sidhu, Christian Wiesmann
  • Anti-pro211 polypeptide antibodies
    Patent number: 7147853
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: December 12, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood, Napoleone Ferrara
  • Fibroblast activation protein inhibitor compounds and methods
    Publication number: 20060276435
    Abstract: Amino terminus-blocked peptide boronate compounds of Formulas I and II are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
    Type: Application
    Filed: May 18, 2006
    Publication date: December 7, 2006
    Applicant: Genentech, Inc.
    Inventors: Frederick Cohen, Wayne Fairbrother, Clifford Quan, Daniel Sutherlin, Beni Wolf
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060275864
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 20, 2004
    Publication date: December 7, 2006
    Applicant: GENENTECH, INC.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Jennie Mather, James Pan, Nicholas Paoni, Margaret Roy, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Pantropic neurotrophic factors
    Patent number: 7144983
    Abstract: Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: December 5, 2006
    Assignee: Genentech, Inc.
    Inventors: Roman Urfer, Leonard G. Presta, John W. Winslow
  • Nucleic acid encoding human suppressor of fused
    Patent number: 7144996
    Abstract: The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: December 5, 2006
    Assignee: Genentech, Inc.
    Inventors: Frederic J. de Sauvage, Maximilien Murone, Arnon Rosenthal, Donna M. Stone, Austin L. Gurney, William I. Wood
  • Antibody to a polypeptide overexpressed in tumors
    Patent number: 7144990
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: December 5, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Vascular endothelial cell growth factor variants and uses thereof
    Publication number: 20060269997
    Abstract: The present invention provides VEGF variants having at least a single amino acid mutation in the native VEGF sequence and selective binding affinity for either the KDR receptor or the FLT-1 receptor. Methods of making the VEGF variants and methods of using the VEGF variants are also provided.
    Type: Application
    Filed: March 15, 2006
    Publication date: November 30, 2006
    Applicant: Genentech, Inc.
    Inventors: Brian Cunningham, Abraham de Vos, Bing Li
  • Antibodies to PRO1561 polypeptide
    Patent number: 7141652
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: November 28, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Control of metabolism with human 2-oxoglutarate carrier
    Patent number: 7141421
    Abstract: The present invention is directed to compositions and methods related to the use of human OGC as an uncoupling protein.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: November 28, 2006
    Assignee: Genentech, Inc.
    Inventors: Sean H. Adams, Xing Xian Yu
  • Compositions and methods for the treatment of immune related diseases
    Publication number: 20060263774
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: October 30, 2003
    Publication date: November 23, 2006
    Applicant: Genentech, Inc.
    Inventors: Hilary Clark, Jill Schoenfeld, Menno VanLookeren, P Williams, William Wood, Thomas Wu
  • Novel compositions and methods for the treatment of psoriasis
    Publication number: 20060258574
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of psoriasis.
    Type: Application
    Filed: August 28, 2003
    Publication date: November 16, 2006
    Applicant: Genentech, Inc.
    Inventor: Sarah Bodary