Patents Assigned to Genentech
  • Catheter Composition and Uses Thereof
    Publication number: 20060257390
    Abstract: A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise a chelating agent.
    Type: Application
    Filed: June 23, 2006
    Publication date: November 16, 2006
    Applicant: Genentech, Inc.
    Inventor: Charles Semba
  • PRO20044 nucleic acids
    Patent number: 7135334
    Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: November 14, 2006
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Napoleone Ferrara, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Kenneth J. Hillan, Scot A. Marsters, James Pan, Jean-Philippe F. Stephan, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Weilan Ye
  • PRO273 polypeptides
    Patent number: 7132283
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: November 7, 2006
    Assignee: Genentech, Inc.
    Inventors: Sherman Fong, Audrey Goddard, Kenneth J. Hillan, William I. Wood
  • Catheter Composition and Uses Thereof
    Publication number: 20060246050
    Abstract: A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise a chelating agent.
    Type: Application
    Filed: June 23, 2006
    Publication date: November 2, 2006
    Applicant: Genentech, Inc.
    Inventor: Charles Semba
  • Compositions and methods for screening pro-apoptotic compounds
    Publication number: 20060246471
    Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: December 9, 2005
    Publication date: November 2, 2006
    Applicants: Genentech, Inc., The Burnham Institute
    Inventors: Wayne Fairbrother, Matthew Franklin, Heidi Wallweber, Linda Elliott, Saloumeh Kadkhodayan, Domagoj Vucic, Guy Sallvesen
  • System for antibody expression and assembly
    Publication number: 20060246542
    Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: February 9, 2006
    Publication date: November 2, 2006
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Dana Andersen
  • Antibody variants and uses thereof
    Publication number: 20060246004
    Abstract: The invention provides improved humanized CD20 binding antibodies for treatment of B cell malignancies and autoimmune diseases.
    Type: Application
    Filed: February 6, 2006
    Publication date: November 2, 2006
    Applicant: Genentech, Inc.
    Inventors: Camellia Adams, Henry Lowman, Gerald Nakamura
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7129324
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: October 31, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Jean-Philippe F. Stephan, William I. Wood
  • Pro9836 polypeptides
    Patent number: 7129325
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: October 31, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Jean-Philippe F. Stephan, Colin K. Watanabe, William I. Wood
  • PRO4405 polypeptides
    Patent number: 7125959
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 26, 2001
    Date of Patent: October 24, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Anti-Pro268 antibodies
    Patent number: 7125962
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: October 24, 2006
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Assay method
    Publication number: 20060234306
    Abstract: A new method for assaying the ability of a compound to block the binding of an ?4 integrin to a binding partner thereof provides a useful screening tool.
    Type: Application
    Filed: June 16, 2006
    Publication date: October 19, 2006
    Applicant: Genentech, Inc.
    Inventors: Dean Artis, David Jackson, Susan Keating, Maureen Beresini
  • Polypeptide variants with altered effector function
    Patent number: 7122637
    Abstract: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: October 17, 2006
    Assignee: Genentech, Inc.
    Inventor: Leonard Presta
  • PRO274 nucleic acids
    Patent number: 7122375
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: October 17, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, William I. Wood
  • Antibody fragment-polymer conjugates and uses of same
    Patent number: 7122636
    Abstract: Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment. Also described are conjugates directed against human vascular endothelial growth factor (VEGF), human p185 receptor-like tyrosine kinase (HER2), human CD20, human CD18, human CD11a, human IgE, human apoptosis receptor-2 (Apo-2), human tumor necrosis factor-? (TNF-?), human tissue factor (TF), human ?4?7 integrin, human GPIIb-IIIa integrin, human epidermal growth factor receptor (EGFR), human CD3, and human interleukin-2 receptor ?-chain (TAC) for diagnostic and therapeutic applications.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 17, 2006
    Assignee: Genentech, Inc.
    Inventors: Vanessa Hsei, Iphigenia Koumenis, Steven Leong, Zahra Shahrokh, Gerardo Zapata
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7122631
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: February 2, 2005
    Date of Patent: October 17, 2006
    Assignee: Genentech, Inc.
    Inventors: Napoleone Ferrara, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Lymphocyte homing receptors
    Publication number: 20060229435
    Abstract: DNA isolates coding for the lymphocyte homing receptor and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the lymphocyte homing receptor useful in therapeutic or diagnostic compositions.
    Type: Application
    Filed: January 5, 2006
    Publication date: October 12, 2006
    Applicant: Genentech, Inc.
    Inventors: Laurence Lasky, Scott Stachel, Steven Rosen, Mark Singer, Ted Yednock
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7119177
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: October 10, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Nucleic acid overexpressed in esophageal tumor, normal stomach and melanoma
    Patent number: 7118887
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: October 10, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7119173
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: October 10, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood