Patents Assigned to Genentech
  • Anti-pro 1343 antibodies
    Patent number: 7026455
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: April 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7026448
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: April 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7026449
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: April 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood
  • Polynucleotides encoding GFR?3
    Patent number: 7026138
    Abstract: The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFR?3, a novel ?-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an ?-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced ?-subunit receptor homo-dimerization or homo-oligomerization.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: April 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Frederic J. de Sauvage, Robert D. Klein, Heidi S. Phillips, Arnon Rosenthal
  • Angiogenesis associated proteins, and nucleic acids encoding the same
    Publication number: 20060074023
    Abstract: An isolated polypeptide having at least 80% sequence identity to the sequence SEQ ID NOS:2, 4, 6, 8, 10, 12, 14 or 16, and polynucleotides encoding the same, are useful for modulating angiogenesis.
    Type: Application
    Filed: November 22, 2005
    Publication date: April 6, 2006
    Applicants: CuraGen Corporation, Genentech, Inc.
    Inventors: Mary Gerritsen, Luca Rastelli
  • Methods and compositions for modulating and detecting wisp activity
    Publication number: 20060073135
    Abstract: Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are pronided. WISP-1 antagonists inlcude anti-WISP-1 antiboties, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of IIAS2, IIA, CD4 or RIIAMM by native human WISP-1 polypeptide in at least one type of cells or pathological conditions associated with native WISP-1 polypeptides.
    Type: Application
    Filed: June 28, 2003
    Publication date: April 6, 2006
    Applicant: Genentech, Inc.
    Inventors: Luc Desnoyers, Ellen Filvaroff
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060073568
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: November 30, 2005
    Publication date: April 6, 2006
    Applicant: Genentech, Inc.
    Inventors: Kevin Baker, Maureen Beresini, Laura DeForge, Luc Desnoyers, Ellen Filvaroff, Wei-Qiang Gao, Mary Gerritsen, Audrey Goddard, Paul Godowski, Austin Gurney, Steven Sherwood, Victoria Smith, Timothy Stewart, Daniel Tumas, Colin Watanabe, William Wood, Zemin Zhang
  • Therapeutic agents with decreased toxicity
    Publication number: 20060073152
    Abstract: The present invention relates to therapeutic agents with reduced toxicity comprising a serum albumin binding peptide (SABP), a targeting agent and a cytotoxic agent. The present invention also relates to methods for reducing the toxicity of therapeutic agents and methods of treatment using the therapeutic agents with reduced toxicity.
    Type: Application
    Filed: September 22, 2005
    Publication date: April 6, 2006
    Applicant: Genentech, Inc.
    Inventor: Mark Dennis
  • Anti-Fc-gamma RIIB receptor antibody and uses therefor
    Publication number: 20060073142
    Abstract: The present application describes antibodies that selectively bind human FcyRIIB, with little or no binding to other human Fc?Rs, e.g., human Fc?RIIA. The invention also provides isolated bispecific antibodies comprising an antibody that selectively binds Fc?RIIB, and a second antibody that specifically binds an activating receptor. Various uses, including therapeutic uses, for those antibodies are also described, including administration with anti-tumor antibodies and methods of inhibiting immune responses and suppressing histamine release.
    Type: Application
    Filed: September 1, 2005
    Publication date: April 6, 2006
    Applicant: Genentech, Inc.
    Inventors: Andrew Chan, Robert Shields, Lawren Wu
  • PRO1325 polypeptides
    Patent number: 7022817
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: April 4, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Pro 1325 nucleic acids
    Patent number: 7022498
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: April 4, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • Polypeptide variants with altered effector function
    Publication number: 20060067930
    Abstract: The invention provides polypeptides having IgG Fc regions with amino acid modifications that result in the polypeptides exhibiting altered Fc effector functions.
    Type: Application
    Filed: August 19, 2005
    Publication date: March 30, 2006
    Applicant: Genentech, Inc.
    Inventors: Camellia Adams, Samantha Lien, Henry Lowman, Jonathan Marvin, Yu-Ju Meng
  • Crystal structure of the complex of hepatocyte growth factor beta chain with Met receptor and methods of use
    Publication number: 20060069019
    Abstract: The disclosure provides a crystal structure of a complex of the HGF ?-chain with am extracellular fragment of the Met receptor, as well as use of the crystal structure in the design, identification, and selection of ligands that modulate the Met Receptor and the interaction of HGF with the Met receptor.
    Type: Application
    Filed: May 6, 2005
    Publication date: March 30, 2006
    Applicant: Genentech, Inc.
    Inventors: Christian Wiesmann, Jennifer Stamos
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060068413
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: March 25, 2005
    Publication date: March 30, 2006
    Applicant: Genentech, Inc.
    Inventors: Kevin Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul Godowski, Austin Gurney, James Pan, Victoria Smith, Colin Watanabe, William Wood, Zemin Zhang
  • DNase liquid solutions
    Patent number: 7018825
    Abstract: The present invention relates to the use of calcium ion and/or sugars to minimize thermal aggregation of DNase and to the use of calcium ion to stabilize liquid solutions of DNase, the solutions having a pH of less than neutral. DNase is the active pharmaceutical principle and the solutions may contain other pharmaceutically acceptable excipients making them suitable for pharmaceutical administration. In the first instance, calcium ion/sugar minimizes the effects of thermal aggregation in the solution. In the second aspect, calcium ion stabilizes the lower pH solutions from protein precipitation.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: March 28, 2006
    Assignee: Genentech, Inc.
    Inventors: Hak-Kim Chan, Igor Gonda, Steven J. Shire, Suzanne Sin-Mui Lo Weck
  • Expression of functional antibody fragments
    Patent number: 7018809
    Abstract: Methods for the high yield production of antibody Fv-containing polypeptides, especially Fab? and F(ab?)2 antibody fragments are provided. Expression of heavy and light chain Fv in a microbial secretory system is followed by recovery of Fv from the periplasm under conditions that maintain a cysteine residue as a free thiol. The free thiol is reacted with free thiol of an antibody fragment of the same or differing specificity, or with agents such as diagnostic labels or therapeutic moieties. The products offer advantages of homogeneity and purity not available through the use of known methods for preparing such derivatives.
    Type: Grant
    Filed: September 18, 1992
    Date of Patent: March 28, 2006
    Assignee: Genentech, Inc.
    Inventor: Paul J. Carter
  • Pro1017 polypeptides
    Patent number: 7019115
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: March 28, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Nucleic acids encoding PRO189 polypeptides
    Patent number: 7018811
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: March 28, 2006
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, William I. Wood
  • PRO 1387 polypeptides
    Patent number: 7019116
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: March 28, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Colin K. Watanabe, William I. Wood
  • PRO788 nucleic acids
    Patent number: 7019124
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: March 28, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood