Patents Assigned to Genentech
  • PRO4340 nucleic acids
    Patent number: 7074910
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: July 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Steven Sherwood, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, William I. Wood
  • Method for enhancing proliferation or differentiation of a cell using ob protein
    Patent number: 7074397
    Abstract: Uses for WSX ligands in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for stimulating hematopoiesis (e.g., myelopoiesis, erythropoiesis and especially, lymphopoiesis) using a WSX ligand (e.g., anti-WSX receptor agonist antibodies or OB protein), and optionally another cytokine, are described.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: July 11, 2006
    Assignee: Genentech, Inc.
    Inventor: William Matthews
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7074912
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: July 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Dan L. Eaton, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • PRO 703 nucleic acids
    Patent number: 7074593
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: July 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, William I. Wood
  • Protein purification
    Patent number: 7074404
    Abstract: A method for purifying a polypeptide by ion exchange chromatography is described which involves changing the conductivity and/or pH of buffers in order to resolve a polypeptide of interest from one or more contaminants.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: July 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Carol D. Basey, Greg S. Blank
  • Pro943 polypeptides
    Patent number: 7074897
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: July 11, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20060147374
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: January 18, 2006
    Publication date: July 6, 2006
    Applicant: Genentech, Inc.
    Inventors: Gretchen Frantz, Kenneth Hillan, Paul Polakis, Beni Wolf, Thomas Wu, Zemin Zhang
  • HIV envelope polynucleotides and immunogenic composition
    Patent number: 7071322
    Abstract: Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides from one or more of the isolates in a subunit vaccine, usually together with MN-rgp120, can provide protection against HIV strains that are sufficiently different from the vaccine strain (e.g.; MN-rgp120) that the vaccine does not confer protection against those strains. Antibodies induced by the polypeptides are also provided.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: July 4, 2006
    Assignee: Genentech, Inc.
    Inventor: Phillip W. Berman
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7070979
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: July 4, 2006
    Assignee: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, William I. Wood
  • IGF antagonist peptides
    Patent number: 7071300
    Abstract: Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: July 4, 2006
    Assignee: Genentech, Inc.
    Inventors: Kurt D. Deshayes, Henry B. Lowman, Michelle L. Schaffer, Sachdev S. Sidhu
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7071304
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: July 4, 2006
    Assignee: Genentech, Inc.
    Inventors: Dan L. Eaton, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7070955
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: July 4, 2006
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Ivar J. Kljavin, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Zemin Zhang
  • Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
    Publication number: 20060141573
    Abstract: The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 29, 2006
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Audrey Goddard, Austin Gurney, Scot Marsters, Robert Pitti, William Wood
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20060140961
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: January 23, 2006
    Publication date: June 29, 2006
    Applicant: Genentech, Inc.
    Inventors: Gretchen Frantz, Kenneth Hillan, Paul Polakis, Beni Wolf, Thomas Wu, Zemin Zhang
  • Anti-pro 1017 antibodies
    Patent number: 7067636
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: June 27, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • AL-1 neurotrophic factor treatments
    Patent number: 7067484
    Abstract: The present invention provides nucleic acids encoding AL-1 protein, as well as AL-1 protein produced by recombinant DNA methods. Such AL-1 protein is useful in preparing antibodies and in diagnosing and treating various neuronal disorders.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: June 27, 2006
    Assignee: Genentech, Inc.
    Inventors: Ingrid W. Caras, John W. Winslow
  • PRO788 polypeptides
    Patent number: 7067628
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: June 27, 2006
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Compositions and methods for the screening pro-apoptotic compounds
    Patent number: 7067274
    Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: June 27, 2006
    Assignees: Genentech, Inc., The Burnham Institute
    Inventors: Wayne J. Fairbrother, Matthew C. Franklin, Heidi Jenii Ackerly Wallweber, Linda Orren Elliott, Saloumeh Kadkhodayan, Domagoj Vucic, Guy Salvesen
  • Antiangiogenesis therapy of autoimmune disease in patients who have failed prior therapy
    Publication number: 20060134111
    Abstract: The present application describes therapy with angiogenesis antagonists such as anti-VEGF antibodies. In particular, the application describes the use of such antagonists to treat autoimmune disease in a patient who has failed prior treatment such as treatment with DMARDs or TNF?-inhibitors.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 22, 2006
    Applicant: Genentech, Inc.
    Inventor: Sunil Agarwal
  • Humanized anti-cmet antagonists
    Publication number: 20060134104
    Abstract: The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.
    Type: Application
    Filed: August 4, 2005
    Publication date: June 22, 2006
    Applicant: Genentech, Inc.
    Inventors: Mark Dennis, Karen Billeci, Judy Young, Zhong Zheng