Abstract: A method, system, and non-transitory computer readable medium for predicting cell viability of a cell culture in a bioreactor during a biomolecule manufacturing process are disclosed. In various embodiments, at least three manufacturing process parameters related to the process for manufacturing molecules are input into a machine learning model that is trained to predict cell viabilities. The trained machine learning model may then analyze the at least three manufacturing process parameters to generate an indicator of cell viability of the cell culture.
Type:
Application
Filed:
September 8, 2023
Publication date:
March 14, 2024
Applicant:
GENENTECH, INC.
Inventors:
Arthi NARAYANAN, Aditya Avdhut WALVEKAR, Georo L. ZHOU, Nicholas RUMMEL, Zheng LI, Steven J. MEIER
Abstract: The present invention relates to the field of protein purification. In particular, the invention concerns methods for increasing the filtration capacity of virus filters, by combined use of endotoxin removal and cation-exchange media in the prefiltration process.
Abstract: The present disclosure relates to methods and compositions useful for measuring the transcytosis or recycling of a molecule. In particular, the present disclosure relates to in vitro receptor-dependent transcytosis or recycling assays for evaluating the clearance rates of therapeutic antibody molecules and Fc-fusion proteins in humans and animals.
Type:
Application
Filed:
October 13, 2023
Publication date:
March 14, 2024
Applicant:
Genentech, Inc.
Inventors:
Chang LIU, John Hok Nin LOWE, Shan CHUNG
Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.
Type:
Application
Filed:
September 11, 2023
Publication date:
March 14, 2024
Applicant:
Genentech, Inc.
Inventors:
James Thomas Koerber, Wyne Pun Lee, Tangsheng Yi, Juan Zhang, Cary Dean Austin, Cecilia Pui Chi Chiu, Joseph Edward Chavarria-Smith, Jawahar Sudhamsu
Abstract: The present disclosure relates to techniques for abstraction of unstructured clinical trial health data. Particularly, aspects are directed to obtaining, by a data transformation system, an unstructured document that includes various types of content for a given event. The data transformation system converts the unstructured document from an original format into a standardized format. The data transformation system processes the unstructured document in the standardized format to identify template-mapped content data and processes the template-mapped content data to identify high-interest content data. The data transformation system generates a dictionary data structure comprising key-value pairs for each of the template-mapped content data and the high-interest content data. The data transformation system generates a structured document based on the dictionary data structure for each of the template-mapped content data and the high-interest content data.
Type:
Application
Filed:
November 21, 2023
Publication date:
March 14, 2024
Applicant:
GENENTECH, INC.
Inventors:
Lukas Robert Corey, Jennifer Renee Crawford, Connor Patrick Douglas, Benjamin Pamandanan Femandez
Abstract: The present disclosure relates to methods of administering Compound I for treating fibrotic disorders, inflammatory disorders or autoimmune disorders.
Type:
Grant
Filed:
November 17, 2021
Date of Patent:
March 12, 2024
Assignee:
GENENTECH, INC.
Inventors:
Lin Pan, Dorothy Sze-Wing Cheung, Jeffrey Mark Harris, Indiana Strombom
Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.
Abstract: Provided herein are combination therapies comprising GDC-9545 and a CDK4/6 inhibitor for treating locally advanced breast cancer or metastatic breast cancer.
Type:
Grant
Filed:
May 10, 2021
Date of Patent:
March 5, 2024
Assignee:
Genentech, Inc.
Inventors:
Jennifer O'Hara Lauchle, Sandra Milan, Melanie Carol Smitt, Marjorie C. Green
Abstract: The invention provides isoform-selective anti-TGF? antibodies and methods of using the same. In particular, isoform-selective anti-TGF?2, anti-TGF?3, and anti-TGF?2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGF?-related disorders.
Type:
Grant
Filed:
March 18, 2021
Date of Patent:
March 5, 2024
Assignee:
GENENTECH, INC.
Inventors:
Wei-Ching Liang, Joseph R. Arron, Daryle Depianto, Wendy Green Halpern, WeiYu Lin, Patrick J. Lupardus, Thirumalai Rajan Ramalingam, Dhaya Seshasayee, Tianhe Sun, Tulika Tyagi, Jia Wu, Yan Wu, Jian Ping Yin
Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.
Type:
Grant
Filed:
May 13, 2021
Date of Patent:
February 27, 2024
Assignee:
Genentech, Inc.
Inventors:
Ganesh Prasadh Vissvesvaran, Robert David Kiss, Steven J. Meier, Inchan Kwon, Kara Calhoun, Kate Winchester, Amelia Adams, Marion Glenn, Stefan Koenig, Alan Deese
Abstract: The present invention generally relates to nanolipoprotein particle conjugates comprising at least one polypeptide and nanolipoprotein particle conjugates comprising at least one short peptide between 20-60 amino acids in length. Also provided are related compositions and systems, and methods of preparing and using same. In particular, nanolipoprotein particle (NLP) conjugates with antigen-binding fragments (Fabs) are provided, where the NLP comprises a bilayer of membrane-forming lipids encircled by scaffold proteins, and the Fabs are conjugated to one or both bilayer surfaces. In some embodiments, the (NLP) conjugates further comprise a short peptide 20-60 amino acids in length.
Type:
Application
Filed:
December 9, 2022
Publication date:
February 22, 2024
Applicant:
Genentech, Inc
Inventors:
Whitney BINDER, Craig D. BLANCHETTE, Martine A. DARWISH, Rami HANNOUSH, Xinxin GAO
Abstract: The present disclosure provides polysorbate 20 compositions with particular fatty acid ester concentrations. In some embodiments, they may be used in pharmaceutical formulations, for example, to improve stability.
Type:
Application
Filed:
October 26, 2023
Publication date:
February 15, 2024
Applicant:
Genentech, Inc.
Inventors:
Sandeep Yadav, Nidhi Doshi, Tomanna Shobha, Anthony Tomlinson, Amit Srivastava
Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.
Type:
Application
Filed:
October 20, 2023
Publication date:
February 15, 2024
Applicant:
GENENTECH, INC.
Inventors:
Steven J. Meier, Melissa S. Mun, Natarajan Vijayasankaran, Sharat Varma, Yi Yang, Boyan Zhang, Silvana R. Arevalo, Martin Gawlitzek, Veronica Carvalhal
Abstract: Drug delivery systems and methods of use thereof for recording administration of a drug dose to a subject are provided. Aspects of the invention include a syringe stopper rod comprising a sensor component that is configured to detect a delivery signature, and to transmit a report comprising a drug dose completion signal to a data management component, e.g., a mobile computing device.
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Type:
Grant
Filed:
October 7, 2022
Date of Patent:
February 13, 2024
Assignees:
AbbVie Inc., Genentech, Inc., The Walter and Eliza Hall Institute of Medical Research
Inventors:
Milan Bruncko, Hong Ding, George A. Doherty, Steven W. Elmore, Lisa A. Hasvold, Laura Hexamer, Aaron R. Kunzer, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt, Robert Mantei, Todd M. Hansen