Abstract: Provided herein are methods of treating or preventing herpesvirus infection comprising modulating interactions between herpesvirus surface proteins and plasma membrane-expressed host cell proteins, as well as methods of identifying modulators of such interactions.
Abstract: Herein are reported modified mammalian cells wherein the expression of the MYC gene and one or more of the BAK, BAX, SIRT-1 and ICAM-1 genes has been reduced or eliminated as well as methods for the recombinant production of a heterologous polypeptide using a modified mammalian cell according to the current invention. Further reported are use of the reduction of the expression of the genes for increasing volumetric productivity, increasing cell volume, increasing viability and increasing the possible cultivation time without cell split.
Type:
Application
Filed:
April 19, 2023
Publication date:
January 11, 2024
Applicants:
Genentech, Inc., Hoffmann-La Roche Inc.
Inventors:
Shahram Misaghi, Amy Shen, Inn Huam Yuk, Gavin Christian Barnard, Simon Auslaender, Niels Bauer, Benedikt Oswald
Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
January 9, 2024
Assignee:
Genentech, Inc.
Inventors:
Diego Ellerman, Teemu T. Junttila, Twyla Noelle Lombana, Dionysos Slaga, Christoph Spiess
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
Type:
Grant
Filed:
April 19, 2021
Date of Patent:
January 9, 2024
Assignee:
Genentech, Inc.
Inventors:
Yvonne Chen, Mark Dennis, Kristi Elkins, Jagath Reddy Junutula, Andrew Polson, Bing Zheng
Abstract: The present disclosure provides liquid formulations comprising polypeptides and surfactants. In particular, it discloses a liquid formulation comprising a polypeptide and a surfactant, wherein at least about 70% (wt %) of the surfactant are isosorbide polyoxyethylene (POE) fatty acid esters. The invention also provides methods for making such liquid formulations, articles of manufacture comprising such liquid formulations and methods of treating a patient with such liquid formulations.
Type:
Grant
Filed:
June 26, 2020
Date of Patent:
January 9, 2024
Assignee:
GENENTECH, INC.
Inventors:
Anthony Tomlinson, Barthelemy Luc Demeule, Isidro Angelo Eleazar Zarraga
Abstract: A system for making a sterile connection of at least one conduit is provided. The system includes a clamp for securing the conduit and for delivering inductive energy to sterilize an interior of the conduit. The system includes an insert for delivering inductive energy to sterilize an interior of the conduit. The system includes a cradle for directly supporting the clamp and indirectly supporting the insert inside the conduit. The system includes an operating system and a device for generating inductive heat. Related methods, apparatuses, devices, systems, techniques and articles are also described.
Type:
Application
Filed:
May 31, 2023
Publication date:
January 4, 2024
Applicant:
Genentech, Inc.
Inventors:
Luis Fernando Caldera, Arthi Narayanan, Trishna Ray-Chaudhuri, Nicholas Rummel
Abstract: The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a CD20-expressing cancer.
Type:
Application
Filed:
September 7, 2023
Publication date:
January 4, 2024
Applicants:
GENENTECH, INC., HOFFMANN-LA ROCHE INC., ABBVIE INC.
Inventors:
Deepak Sampath, Christian Klein, Wayne John Fairbrother, Sari L. Heitner Enschede, Rod A. Humerickhouse, Andrew W. Roberts, John F. Seymour
Abstract: The present invention provides diagnostic and therapeutic methods and compositions for cancer. The invention provides methods of determining whether an individual having a cancer is likely to respond to treatment comprising a pan-RAF dimer inhibitor and a MEK or PI3K inhibitor, methods of predicting responsiveness of an individual having a cancer to treatment comprising a pan-RAF dimer inhibitor and a MEK or PI3K inhibitor, methods of selecting a therapy for an individual having a cancer, and methods of treating an individual having cancer based on the presence of a biomarker of the invention (e.g., a KRAS activating mutation, e.g., a KRAS-G13D mutation, or an NRAS activating mutation).
Type:
Grant
Filed:
September 7, 2018
Date of Patent:
January 2, 2024
Assignee:
Genentech, Inc.
Inventors:
Christiaan Nicolaas Klijn, Shiva Malek, Ivana Yen
Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.
Type:
Grant
Filed:
May 26, 2020
Date of Patent:
January 2, 2024
Assignee:
Genentech, Inc.
Inventors:
Martine Darwish, Surinder Kaur, Dian Su, Keyang Xu
Abstract: A composition comprising a main species HER2 antibody that binds to domain II of HER2 and acidic variants thereof is described. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.
Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.
Type:
Application
Filed:
March 29, 2023
Publication date:
December 28, 2023
Applicant:
Genentech, Inc.
Inventors:
Amy Dressen, David B. Iaea, Moulay Hicham Alaoui Ismaili, Janet K. Jackman, Robert A. Lazarus, Kelly Michele Loyet, Henry R. Maun, Brian Louis Yaspan, Tangsheng Yi, Joseph R. Arron, Hilda Y Hernandez-Barry
Abstract: The present disclosure relates to methods and kits for detecting a free thiol in a substrate as well as methods for quantifying the amount of free thiol in a substrate. In particular, the present disclosure provides a fluorescent Ellman assay for enhanced sensitivity of free thiol detection and quantification.
Type:
Application
Filed:
April 28, 2023
Publication date:
December 21, 2023
Applicant:
GENENTECH, INC.
Inventors:
Aron Lee, Rashmi Sharma, Justin Joo-Ho Jeong, Michael Tae-Jon Kim
Abstract: Apparatus and methods for delivering medicament. The apparatus may include a fitting for a fluid dispenser. The fitting may include a detent that is configured to limit insertion of the dispenser into the fitting by contacting a terminal surface of the dispenser; and a seal for sealing against the surface. The apparatus may include an insert for the fitting. The insert may include a gasket to seal against the terminal surface of the dispenser; a proximal rim to engage a lateral wall of the dispenser; and a connector fixed to the gasket and the rim. The apparatus may include a coupler to engage a pre-filled dispenser; and a body defining a passageway that is configured to be placed in fluid communication with the dispenser. The apparatus may include a dispenser that includes a detent and a seal. The detent may limit insertion of the dispenser into a fitting.
Abstract: The present invention relates to complement component 1s (C1S) inhibitors for use in treatment of neurological diseases. The invention in particular relates to the use of C1S inhibitors for down-regulation of C1S expression. The invention also relates to nucleic acid molecules, which are complementary to C1S and capable of reducing the level of an C1S mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of neurological diseases.
Type:
Application
Filed:
November 9, 2022
Publication date:
December 14, 2023
Applicant:
Genentech, Inc.
Inventors:
Alexander MUNK, Helene M. GYLLING, Jesse Eric HANSON, Lukasz J. KIELPINSKI
Abstract: The present disclosure relates to compounds comprising a VHL ligand moiety and to methods of using such compounds as ligands of VHL. The present disclosure further relates to the use of the compounds described herein, or pharmaceutical compositions thereof, to prevent and/or treat a range of diseases, disorders, and conditions.
Type:
Application
Filed:
May 9, 2023
Publication date:
December 7, 2023
Applicant:
Genentech, Inc.
Inventors:
Jakob FUHRMANN, Hao WU, Wayne J. FAIRBROTHER