Patents Assigned to Genentech
  • Assays for detecting T cell immune subsets and methods of use thereof
    Patent number: 10845364
    Abstract: The present disclosure provides methods for measuring the number of CD4+ OX40+ Foxp3+ lymphocytes in a sample containing cancer cells and lymphocytes obtained from a subject by labeling lymphocytes that show CD4 expression in the sample, then labeling lymphocytes that show OX40 expression in the sample, then labeling lymphocytes that show Foxp3 expression in the sample, then measuring the number of CD4+ OX40+ Foxp3+ lymphocytes in the sample. Further provided are methods for determining the prognosis of a subject, predicting responsiveness of a subject having cancer to an OX40 agonist treatment, and methods for treating or delaying progression of cancer based on the number of CD4+ OX40+ Foxp3+ lymphocytes in a sample.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 24, 2020
    Assignee: Genentech, Inc.
    Inventors: Felix Chu, Oded Foreman, James Ziai
  • Serine/threonine kinase inhibitors
    Patent number: 10842799
    Abstract: Compounds having the formula I wherein R1, X1, X2, X3 and X4 as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: November 24, 2020
    Assignee: GENENTECH, INC.
    Inventors: Aleksandr Kolesnikov, Steven Do
  • METHODS FOR THE TREATMENT OF EPILEPSY
    Publication number: 20200362042
    Abstract: The invention provides methods for the treatment of seizures and epilepsy using FGF21 receptor activators.
    Type: Application
    Filed: August 5, 2020
    Publication date: November 19, 2020
    Applicant: GENENTECH, INC.
    Inventor: Sharmila Rajan
  • Anti-Tau antibodies and methods of use
    Patent number: 10836817
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: November 17, 2020
    Assignees: AC Immune SA, Genentech, Inc.
    Inventors: Oskar Adolfsson, Kristin Ruth Wildsmith, Marcel Van Der Brug, Andreas Muhs
  • SYNTHESIS OF LABELED IMIDAZO[1,2-A]PYRIMIDINES
    Publication number: 20200354369
    Abstract: A method of synthesizing comprising a step of making an imidazo-pyrimidine compound by coupling a first compound of formula (II) with a second compound of formula (III) Followed by a deprotection and tosylation step. The methods are able to produce an isotopically substituted molecule having upwards of 95% purity relative to non-isotopically substituted molecules.
    Type: Application
    Filed: May 7, 2020
    Publication date: November 12, 2020
    Applicant: Genentech, Inc.
    Inventors: Kyle Bradley Pascual Clagg, Nicholas Andrew White, Haiming Zhang, Francis Gosselin, William Nack, Paul D. O'Shea
  • THERAPEUTIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF USE THEREOF
    Publication number: 20200352951
    Abstract: Methods of using compounds and salts thereof as JAK kinase inhibitors are described herein, including methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
    Type: Application
    Filed: July 28, 2020
    Publication date: November 12, 2020
    Applicant: Genentech, Inc.
    Inventors: Mark ZAK, F. Anthony ROMERO, Yun-Xing CHENG
  • Cell culture compositions with antioxidants and methods for polypeptide production
    Patent number: 10829732
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: November 10, 2020
    Assignee: Genentech, Inc.
    Inventors: Natarajan Vijayasankaran, Steven J. Meier, Sharat Varma, Yi Yang
  • PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES
    Publication number: 20200347145
    Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
    Type: Application
    Filed: April 13, 2020
    Publication date: November 5, 2020
    Applicant: Genentech, Inc.
    Inventors: Yung-Hsiang KAO, Michael W. LAIRD, Melody Trexler SCHMIDT, Rita L. WONG, Daniel P. HEWITT
  • HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
    Publication number: 20200345735
    Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
    Type: Application
    Filed: January 7, 2020
    Publication date: November 5, 2020
    Applicants: Array BioPharma Inc., Genentech, Inc.
    Inventors: Ian S. Mitchell, James F. Blake, Rui Xu, Nicholas C. Kallan, Dengming Xiao, Keith Lee Spencer, Josef R. Bencsik, Eli M. Wallace, Stephen T. Schlachter, Anna L. Leivers, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do
  • CELL CULTURE MEDIA AND METHODS OF ANTIBODY PRODUCTION
    Publication number: 20200347122
    Abstract: Cell culture media are provided herein as are methods of using the media for cell culture and antibody production from cells. Compositions comprising antibodies and fragments thereof, produced by the methods herein are also provided.
    Type: Application
    Filed: November 15, 2019
    Publication date: November 5, 2020
    Applicant: Genentech, Inc.
    Inventors: Veronica Carvalhal, Natarajan Vijayasankaran, Lauren Brown, Thomas DiRocco, Nathan McKnight
  • METHOD TO IMPROVE VIRUS FILTRATION CAPACITY
    Publication number: 20200347118
    Abstract: The present invention relates to the field of protein purification. In particular, the invention concerns methods for increasing the filtration capacity of virus filters, by combined use of endotoxin removal and cation-exchange media in the prefiltration process.
    Type: Application
    Filed: April 14, 2020
    Publication date: November 5, 2020
    Applicant: Genentech, Inc.
    Inventor: Amit MEHTA
  • Shape Discrimination Vision Assessment and Tracking System
    Publication number: 20200345227
    Abstract: A method to self-test vision of a user for use with a handheld vision tester includes receiving image data of the user's face, determining dimensions of the user's face based on the received image data, computing a user viewing distance based on the determined dimensions, displaying a vision test based on the computed user viewing distance, receiving user input responses to the vision test, and outputting results of the vision test from the user input responses.
    Type: Application
    Filed: July 21, 2020
    Publication date: November 5, 2020
    Applicant: GENENTECH, INC.
    Inventors: Michael Bartlett, Yi-Zhong Wang
  • Methods and compositions comprising purified recombinant polypeptides
    Patent number: 10822404
    Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: November 3, 2020
    Assignee: Genentech, Inc.
    Inventors: X. Christopher Yu, Susan C. Fisher, Atia Naim, Ailen M. Sanchez, Christopher A. Teske, Martin Vanderlaan, Annamarie Amurao, Jayme Franklin, Corazon Victa
  • PYRAZOLOPYRIMIDINE COMPOUNDS AS JAK INHIBITORS
    Publication number: 20200339604
    Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
    Type: Application
    Filed: July 13, 2020
    Publication date: October 29, 2020
    Applicant: Genentech, Inc.
    Inventors: Mark ZAK, Paul GIBBONS, Yun-Xing CHENG, Simon Charles GOODACRE
  • Cysteine Engineered Antibodies and Conjugates
    Publication number: 20200339664
    Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.
    Type: Application
    Filed: February 11, 2020
    Publication date: October 29, 2020
    Applicant: Genentech, Inc.
    Inventors: Sunil Bhakta, Jagath R. Junutula
  • CYCLIC PEPTIDE ANTIBIOTICS
    Publication number: 20200331968
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: March 12, 2020
    Publication date: October 22, 2020
    Applicant: Genentech, Inc.
    Inventors: Emily J. HANAN, Georgette CASTANEDO, Marie Gabrielle BRAUN, Keira GARLAND, Peter Andrew SMITH, Richard PASTOR, Paul GIBBONS, Yunxing CHENG, Guosheng WU, Yuhong FU, Po-Wai YUEN
  • Prevention of disulfide bond reduction during recombinant production of polypeptides
    Patent number: 10808037
    Abstract: Provided herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: October 20, 2020
    Assignee: Genentech, Inc.
    Inventors: Yung-Hsiang Kao, Michael W. Laird, Melody Trexler Schmidt, Rita L. Wong, Daniel P. Hewitt
  • Methods and compositions for targeting polyubiquitin
    Patent number: 10808028
    Abstract: Anti-K63-linked polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: October 20, 2020
    Assignee: Genentech, Inc.
    Inventors: Robert F. Kelley, Marissa L. Matsumoto
  • Anti-transferrin receptor antibodies and methods of use
    Patent number: 10808036
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: October 20, 2020
    Assignee: GENENTECH, INC.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S. Dennis, James A. Ernst, Ryan J. Watts, Gregory A. Lazar
  • METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE
    Publication number: 20200325538
    Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
    Type: Application
    Filed: April 10, 2020
    Publication date: October 15, 2020
    Applicant: GENENTECH, INC.
    Inventors: Jason A. Hackney, Mary Keir, Gaik Wei Tew