Patents Assigned to Genentech
  • GALACTOENGINEERED IMMUNOGLOBULIN 1 ANTIBODIES
    Publication number: 20200325245
    Abstract: The present invention relates to galactoengineered recombinant antibodies of IgG1 isotype, methods for the production of said antibodies and uses thereof.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 15, 2020
    Applicants: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Sebastian Malik, Dietmar Reusch, Alfred Schnüriger, Max L. Tejada, Marco Thomann
  • CYSTINE KNOT SCAFFOLD PLATFORM
    Publication number: 20200325187
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, Including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Application
    Filed: June 29, 2020
    Publication date: October 15, 2020
    Applicant: Genentech, Inc.
    Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
  • TDO2 Inhibitors
    Patent number: 10800780
    Abstract: Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: October 13, 2020
    Assignees: Genentech, Inc., NewLink Genetics Corporation
    Inventors: Xingyu Lin, Po-wai Yuen, Rohan Mendonca, Brendan Parr, Richard Pastor, Zhonghua Pei, Lewis Gazzard, Firoz Jaipuri, Sanjeev Kumar, Xiaokai Li, Roheeth Pavana, Hima Potturi, Venkata Velvadapu, Jesse Waldo, Zuhui Zhang, Guosheng Wu, Benjamin Douglas Sellers
  • ASSEMBLY OF BISPECIFIC ANTIBODIES
    Publication number: 20200317820
    Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
    Type: Application
    Filed: March 16, 2020
    Publication date: October 8, 2020
    Applicant: Genentech, Inc.
    Inventors: Glen GIESE, Amy LIM, Josefine PERSSON, Justin SCHEER, Ambrose WILLIAMS
  • PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES
    Publication number: 20200317801
    Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
    Type: Application
    Filed: April 13, 2020
    Publication date: October 8, 2020
    Applicant: Genentech, Inc.
    Inventors: Yung-Hsiang KAO, Michael W. LAIRD, Melody Trexler SCHMIDT, Rita L. WONG, Daniel P. HEWITT
  • pH ADJUSTMENT TO IMPROVE THAW RECOVERY OF CELL BANKS
    Publication number: 20200315162
    Abstract: Provided herein are methods of freezing mammalian cells for storage or improving thaw recovery of cell banks comprising freezing mammalian cells in a freezing medium having a pH of 6.7 to 8.5.
    Type: Application
    Filed: February 21, 2020
    Publication date: October 8, 2020
    Applicant: Genentech, Inc.
    Inventors: Angela MEIER, Steven J. MEIER, Phillip DUFFY, Marcia COYNE, Kara CALHOUN
  • Process for making compounds for use in the treatment of cancer
    Patent number: 10793541
    Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: October 6, 2020
    Assignees: Exelixis, Inc., Genentech, Inc.
    Inventors: Sriram Naganathan, Nathan Guz, Matthew Pfeiffer, C. Gregory Sowell, Tracy Bostick, Jason Yang, Amit Srivastava, Neel Kumar Anand
  • 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
    Patent number: 10793550
    Abstract: The invention provides 4-piperidin-chroman-7-sulfonamide derivatives and salts thereof that are sodium channel modulators, as well as compositions containing such a compound or salt and therapeutic methods for using such a compound, salt, or composition.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: October 6, 2020
    Assignee: GENENTECH, INC.
    Inventors: Daniel Sutherlin, Steven McKerrall, Kwong Wah Lai
  • OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS
    Publication number: 20200308161
    Abstract: The invention relates to methods of using compounds formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
    Type: Application
    Filed: June 16, 2020
    Publication date: October 1, 2020
    Applicant: Genentech, Inc.
    Inventors: Jack Alexander Terrett, Huifen Chen, Lea Constantineau-Forget, Robin Larouche-Gauthier, Luce Lépissier, Francis Beaumier, Martin Déry, Chantal Grand-Maître, Claudio Sturino, Matthew Volgraf, Elisia Villemure
  • HINGE MODIFIED ANTIBODY FRAGMENTS AND METHODS OF MAKING
    Publication number: 20200308304
    Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab?)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.
    Type: Application
    Filed: April 17, 2020
    Publication date: October 1, 2020
    Applicant: GENENTECH, INC.
    Inventors: Yu-Ju G. Meng, Hok Seon Kim, Ingrid Kim, Christoph Spiess
  • Systems and methods for two-dimensional chromatography
    Patent number: 10788467
    Abstract: Provided are two-dimensional chromatography systems and methods for separating and/or analyzing complex mixtures of organic compounds. In particularly, a two-dimensional reversed-phase liquid chromatography (RPLC)—supercritical fluid chromatography (SFC) system is described including a trapping column at the interface which collects the analytes eluted from the first dimension chromatography while letting the RPLC mobile phase pass through. The peaks of interest from the RPLC dimension column are effectively focused as sharp concentration pulses on the trapping column, which is subsequently injected onto the second dimension SFC column. The system can be used for simultaneous achiral and chiral analysis of pharmaceutical compounds. The first dimension RPLC separation provides the achiral purity result, and the second dimension SFC separation provides the chiral purity result (enantiomeric excess).
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: September 29, 2020
    Assignee: Genentech, Inc.
    Inventors: Cadapakam Venkatramani, Mohammad Al-Sayah
  • Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
    Patent number: 10788494
    Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: September 29, 2020
    Assignee: Genentech, Inc.
    Inventors: Feny Gunawan, Yi-Chun Hsiao, Denise C. Krawitz, Margaret S. Lin, Martin Vanderlaan, Rajesh Vij, Inn H. Yuk, Judith Zhu-Shimoni
  • Therapeutic compounds and methods of use thereof
    Patent number: 10787446
    Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: September 29, 2020
    Assignees: GENENTECH, INC., XENON PHARMACEUTICALS INC.
    Inventors: Philippe Bergeron, Kristen Burford, Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Abid Hasan, Kwong Wah Lai, Zhiguo Liu, Steven McKerrall, Teresa Phuongtram Nguyen, Brian Safina, Daniel Sutherlin, Tao Wang
  • Compositions and methods for treating cardiovascular disease
    Patent number: 10787484
    Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: September 29, 2020
    Assignee: Genentech, Inc.
    Inventors: Maureen Beresini, Daniel Burdick, Charles Eigenbrot, Jr., Daniel Kirchhofer, Robert Lazarus, Wei Li, John Quinn, Nicholas Skelton, Mark Ultsch, Yingnan Zhang
  • DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BRUTON'S TYROSINE KINASE
    Publication number: 20200299301
    Abstract: The invention relates generally crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the compound (S)-2-(3?-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4?-bipyridin]-2?-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one that is an inhibitor of Bruton's tyrosine kinase. In some aspects, the crystalline salts are single polymorphs.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 24, 2020
    Applicant: Genentech, Inc.
    Inventors: Chen MAO, Dawen KOU, Po-Chang CHIANG
  • DEUTERATED COMPOUNDS AND USES THEREOF
    Publication number: 20200297875
    Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
    Type: Application
    Filed: June 8, 2020
    Publication date: September 24, 2020
    Applicant: Genentech, Inc.
    Inventors: Jan Marik, Joseph P. Lyssikatos, Simon Williams
  • Process for the preparation of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[F]imidazo[1,2-D][1,4]oxazepin-9-yl)amino) propanamide
    Patent number: 10781219
    Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure:
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: September 22, 2020
    Assignee: Genentech, Inc.
    Inventors: Francis Gosselin, Chong Han, Theresa Cravillion, Sean M. Kelly, Scott Savage
  • ANTI-PD-L1 ANTIBODIES AND METHODS OF USING THE SAME FOR DETECTION OF PD-L1
    Publication number: 20200291119
    Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a N detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.
    Type: Application
    Filed: May 27, 2020
    Publication date: September 17, 2020
    Applicant: Genentech, Inc.
    Inventors: Doris KIM, Terence WONG, Anan CHUNTHARAPAI, Cherie Louise GREEN
  • SYNTHETIC CONTROLS FOR IMMUNOHISTOCHEMISTRY
    Publication number: 20200292536
    Abstract: The present disclosure relates to synthetic controls useful, e.g., for immunohistochemistry (IHC), as well as kits and methods of manufacture and use related thereto. In some embodiments, the synthetic controls include a solid antigen/carrier protein gel comprising a purified antigen (e.g., at a known quantity) and a carrier protein such as an albumin protein (e.g., a serum albumin protein), an egg white protein or mixture of egg white proteins, gelatin, or poly-lysine. In some embodiments, the purified antigen is cross-linked to the carrier protein in the solid antigen/carrier protein gel.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Applicant: Genentech, Inc.
    Inventors: Kathy HÖTZEL, Franklin V. PEALE, JR., Charles HAVNAR, Linda RANGELL, Debra Y. DUNLAP
  • CELL CULTURE MEDIA AND METHODS OF ANTIBODY PRODUCTION
    Publication number: 20200291103
    Abstract: Cell culture media are provided herein as are methods of using the media for cell culture and antibody production from cells. Compositions comprising antibodies and fragments thereof, produced by the methods herein are also provided.
    Type: Application
    Filed: October 18, 2019
    Publication date: September 17, 2020
    Applicant: Genentech, Inc.
    Inventors: Veronica CARVALHAL, Natarajan VIJAYASANKARAN, Lauren BROWN, Thomas DIROCCO, Nathan MCKNIGHT