Patents Assigned to Genentech
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 9815905
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: November 14, 2017
    Assignee: Genentech, Inc.
    Inventors: Paul Polakis, Jyoti Asundi, Ron Firestein, Robert F. Kelley, Krista McCutcheon
  • IL-22 Fc fusion proteins
    Patent number: 9815880
    Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: November 14, 2017
    Assignee: Genentech, Inc.
    Inventors: Justin Scheer, Wenjun Ouyang, Richard Vandlen, Philip E. Hass, Eric Gary Stefanich, Xiaoting Wang
  • TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20170320871
    Abstract: Described herein are tetrahydroisoquinoline compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituent and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: April 7, 2017
    Publication date: November 9, 2017
    Applicant: Genentech, Inc.
    Inventors: Sharada Labadie, Jun Liang, Daniel Fred Ortwine, Maia Vinogradova, Xiaojing Wang, Jason Zbieg, Birong Zhang, Tao Wang
  • ANTI-INFLUENZA B VIRUS HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20170320937
    Abstract: The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: July 24, 2017
    Publication date: November 9, 2017
    Applicant: Genentech, Inc.
    Inventors: Lee Swem, Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Gerald R. Nakamura, Hyunjoo Park
  • ANTI-RSPO3 ANTIBODIES AND METHODS OF USE
    Publication number: 20170319688
    Abstract: Provided herein are anti-RSPO3 antibodies and methods of using the same.
    Type: Application
    Filed: April 13, 2017
    Publication date: November 9, 2017
    Applicant: GENENTECH, INC.
    Inventor: Elaine Storm
  • ANTI-ALPHA-SYNUCLEIN ANTIBODIES AND METHODS OF USE
    Publication number: 20170320940
    Abstract: The present invention relates to anti-alpha-synuclein (anti-?-synuclein) antibodies and methods of using the same.
    Type: Application
    Filed: July 7, 2017
    Publication date: November 9, 2017
    Applicant: Genentech, Inc.
    Inventors: Gai Ayalon, Till Mauer
  • Ionic strength-mediated pH gradient ion exchange chromatography
    Patent number: 9810670
    Abstract: The present invention provides methods for analyzing compositions of polypeptides such as antibodies by ionic strength-mediated pH gradient ion exchange chromatography. In some aspects, the methods use a combination of pH gradients and ionic strength gradients to separate the polypeptide from charge variants of the polypeptide. In some aspects, the methods use a stable ionic strength to optimize the pH gradient separation window to separate the polypeptide from charge variants. Such methods are useful for analyzing polypeptide, e.g. antibodies, with a pI greater than 9 or a pI less than 7. In some aspects, the invention provides a multiproduct method for the analysis of polypeptides of varying pI's.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: November 7, 2017
    Assignee: GENENTECH, INC.
    Inventors: Yajun Wang, George Tony Moreno, Boyan Zhang, Liangyi Zhang, Dell Farnan, Thomas Patapoff
  • PROCESS FOR MAKING TRICYCLIC LACTAM COMPOUNDS
    Publication number: 20170313704
    Abstract: Processes are described for the preparation of tricyclic lactam compound of Formula (I), having the structure and intermediates useful for the preparation of (I).
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Applicant: Genentech, Inc.
    Inventors: Ngiap-Kie Lim, Haiming Zhang, Chong Han
  • MULTIPLEXED TOTAL ANTIBODY AND ANTIBODY-CONJUGATED DRUG QUANTIFICATION ASSAY
    Publication number: 20170315132
    Abstract: Methods are disclosed to detect, characterize, measure, and quantify human and humanized antibodies, and their conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.
    Type: Application
    Filed: March 24, 2017
    Publication date: November 2, 2017
    Applicant: Genentech, Inc.
    Inventors: Surinder Kaur, Ola Saad, Manjui Violet Lee
  • PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES
    Publication number: 20170313780
    Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
    Type: Application
    Filed: April 17, 2017
    Publication date: November 2, 2017
    Applicant: Genentech, Inc.
    Inventors: Yung-Hsiang KAO, Michael W. LAIRD, Melody Trexler SCHMIDT, Rita L. WONG, Daniel P. HEWITT
  • Expression and secretion system
    Patent number: 9803191
    Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: October 31, 2017
    Assignee: Genentech, Inc.
    Inventors: Devin Tesar, Xiaocheng Chen, Mark Dennis, Isidro Hotzel
  • METHODS OF USING ANTI-CD79b IMMUNOCONJUGATES
    Publication number: 20170304438
    Abstract: Provided herein are methods of treating B-cell proliferative disorders in particular Follicular Lymphoma and/or Diffuse Large B-Cell Lymphoma using immunoconjugates comprising anti-CD79b antibodies in combination with additional therapeutic agents.
    Type: Application
    Filed: February 23, 2017
    Publication date: October 26, 2017
    Applicant: Genentech, Inc.
    Inventors: Andrew Polson, Shang-Fan Yu, Yu-Waye Chu, Michael Wenger
  • DIAGNOSTIC MARKERS
    Publication number: 20170306419
    Abstract: The present invention provides methods of predicting response to a cancer therapy based on the methylation status of the ERBB2 gene. One aspect of the invention provides a method of predicting response to an EGFR inhibitor therapy based on the methylation status of the ERBB2 gene.
    Type: Application
    Filed: June 29, 2017
    Publication date: October 26, 2017
    Applicant: Genentech, Inc.
    Inventors: Thomas E. Januario, David Shames
  • COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH A CD22 ANTIBODY-DRUG CONJUGATE
    Publication number: 20170306040
    Abstract: The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a CD22 antibody-drug conjugate for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and a CD22 antibody-drug conjugate.
    Type: Application
    Filed: March 7, 2017
    Publication date: October 26, 2017
    Applicants: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: Christian Klein, Sabine Lang, Pablo Umana, Andrew Polson
  • Treatment with anti-VEGF antibodies
    Patent number: 9795672
    Abstract: This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 24, 2017
    Assignee: Genentech, Inc.
    Inventors: Gwendolyn Fyfe, Eric Holmgren, William Novotny
  • ARYL SULTAM DERIVATIVES AS RORc MODULATORS
    Publication number: 20170296550
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, Ar, A, W, X1, X2, X3, X4, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
    Type: Application
    Filed: December 17, 2015
    Publication date: October 19, 2017
    Applicant: Genentech, Inc.
    Inventors: Benjamin Fauber, Olivier Rene
  • Pyridyl inhibitors of hedgehog signalling
    Patent number: 9790183
    Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: October 17, 2017
    Assignee: GENENTECH, INC.
    Inventors: Janet L. Gunzner-Toste, Daniel Sutherlin, Mark S. Stanley, Liang Bao, Georgette M. Castanedo, Rebecca L. Lalonde, Shumei Wang, Mark E. Reynolds, Scott J. Savage, Kimberly Malesky, Michael S. Dina, Michael F. T. Koehler
  • Process for making hydroxylated cyclopentylpyrimidine compounds
    Patent number: 9790190
    Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: October 17, 2017
    Assignees: Array BioPharma Inc., Genentech, Inc.
    Inventors: David Askin, Chong Han, Jonathan W. Lane, Travis Remarchuk, Sagar Shakya, C. Gregory Sowell, Keith L. Spencer, Peter J. Stengel
  • COMBINATION THERAPY COMPRISING OX40 BINDING AGONISTS AND PD-1 AXIS BINDING ANTAGONISTS
    Publication number: 20170290913
    Abstract: The invention provides compositions and methods for treating cancers. The method comprises administering a PD-1 axis binding antagonist and an OX40 binding agonist.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 12, 2017
    Applicant: Genentech, Inc.
    Inventors: Jeanne CHEUNG, Mahrukh HUSENI, Jeong KIM
  • ANTI-CD22 ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20170290920
    Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: April 26, 2017
    Publication date: October 12, 2017
    Applicants: MEDIMMUNE LIMITED, GENENTECH, INC.
    Inventors: Paul Polakis, Andrew Polson, Susan Diane Spencer, Shang-Fan Yu, John A. Flygare, Janet L. Gunzner-Toste, Thomas H. Pillow, Philip Wilson Howard, Luke Masterson