Patents Assigned to Genentech
  • Anti-CLL-1 antibodies and immunoconjugates
    Patent number: 9751946
    Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: September 5, 2017
    Assignee: Genentech, Inc.
    Inventors: Bing Zheng, Andrew Polson, Cecilia Chiu, Wei-Ching Liang, Yan Wu
  • Aryl sultam derivatives as RORc modulators
    Patent number: 9751873
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: September 5, 2017
    Assignee: Genentech, Inc.
    Inventors: Benjamin Fauber, Alberto Gobbi, Olivier Rene, Monique Bodil van Niel, Emanuela Gancia, Simon Gaines, Tammy Ladduwahetty, David Vesey, Stuart Ward, Paul Winship
  • PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS
    Publication number: 20170247337
    Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
    Type: Application
    Filed: May 11, 2017
    Publication date: August 31, 2017
    Applicants: Array BioPharma Inc., Genentech, Inc.
    Inventors: David Askin, Chong Han, Jonathan W. Lane, Travis Remarchuk, Sagar Shakya, C. Gregory Sowell, Keith L. Spencer, Peter J. Stengel
  • Anti-influenza B virus hemagglutinin antibodies and methods of use
    Patent number: 9745365
    Abstract: The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and methods of using the same.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: August 29, 2017
    Assignee: Genentech, Inc.
    Inventors: Lee Swem, Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Gerald R. Nakamura, Hyunjoo Park
  • ANTI-B7-H4 ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20170239366
    Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: December 21, 2016
    Publication date: August 24, 2017
    Applicant: Genentech, Inc.
    Inventors: Steven R. LEONG, Andrew POLSON, Paul POLAKIS, Yan WU, Wei-Ching LIANG, Ron FIRESTEIN
  • ANTI-PMEL17 ANTIBODIES AND IMMUNOCONJUGATES
    Publication number: 20170240645
    Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: February 6, 2017
    Publication date: August 24, 2017
    Applicant: GENENTECH, INC.
    Inventors: Youjun Chen, William Mallet, Paul Polakis, Christine Tan, Jyoti Asundi, Suzanna Clark
  • ANTI-POLYUBIQUITIN ANTIBODIES AND METHODS OF USE
    Publication number: 20170240620
    Abstract: The invention provides anti-polyubiquitin antibodies and methods of using the same.
    Type: Application
    Filed: December 16, 2016
    Publication date: August 24, 2017
    Applicant: Genentech, Inc.
    Inventors: Vishva Dixit, Robert F. Kelley, Marissa L. Matsumoto
  • BIHETEROARYL COMPOUNDS AND USES THEREOF
    Publication number: 20170239246
    Abstract: The present invention provides for compounds of Formula I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula all have the meaning as defined herein.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 24, 2017
    Applicant: Genentech, Inc.
    Inventors: Anthony O. Estrada, Alan G Olivero, Snahel Patel, Michael Siu, Joseph Lyssikatos
  • ESTROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF LOCALLY ADVANCED OR METASTATIC ESTROGEN RECEPTOR POSITIVE BREAST CANCER
    Publication number: 20170239219
    Abstract: Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.
    Type: Application
    Filed: May 8, 2017
    Publication date: August 24, 2017
    Applicant: Genentech, Inc.
    Inventors: Edna Chow Maneval, Boa Tran H. Troung, Isan Chen, Jeffrey H. Hager, Debasish F. Roychowdhury
  • Anti-HtrA1 antibodies and methods of use
    Patent number: 9738727
    Abstract: The invention provides anti-HtrA1 antibodies and methods of using the same.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: August 22, 2017
    Assignee: Genentech, Inc.
    Inventors: Yan Wu, Menno van Lookeren-Campagne, Daniel Kirchhofer, Michael Terry Lipari, Kenneth J. Katschke, Jr., Paul M. Moran, Scott Stawicki, Wei-Ching Liang
  • ANTI-LGR5 ANTIBODIES AND USES THEREOF
    Publication number: 20170233471
    Abstract: The invention provides anti-LgR5 antibodies and methods of using the same.
    Type: Application
    Filed: November 29, 2016
    Publication date: August 17, 2017
    Applicant: GENENTECH, INC.
    Inventors: Andrew G. Polson, Weiguang Mao, Ron Firestein
  • METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE
    Publication number: 20170233809
    Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
    Type: Application
    Filed: September 21, 2016
    Publication date: August 17, 2017
    Applicant: Genentech, Inc.
    Inventors: Jason A. Hackney, Mary Keir, Gaik Wei Tew
  • ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR
    Publication number: 20170234883
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
    Type: Application
    Filed: January 25, 2017
    Publication date: August 17, 2017
    Applicant: Genentech, Inc.
    Inventors: Mark S. DENNIS, Bonnee RUBINFELD, Paul POLAKIS, Aya JAKOBOVITS
  • QUATERNARY AMINE COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF
    Publication number: 20170232113
    Abstract: This invention relates to quaternary amine linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
    Type: Application
    Filed: May 1, 2017
    Publication date: August 17, 2017
    Applicant: Genentech, Inc.
    Inventors: John A. Flygare, Thomas Pillow, Leanna Staben
  • POLYNUCLEOTIDES ENCODING ANTI-NOTCH1 NRR ANTIBODY POLYPEPTIDES
    Publication number: 20170233486
    Abstract: The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.
    Type: Application
    Filed: November 22, 2016
    Publication date: August 17, 2017
    Applicant: Genentech, Inc.
    Inventors: Christian W. Siebel, Yan Wu
  • Anti-?-synuclein antibodies and methods of use
    Patent number: 9732148
    Abstract: The present invention relates to anti-alpha-synuclein (anti-?-synuclein) antibodies and methods of using the same.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: August 15, 2017
    Assignee: Genentech, Inc.
    Inventors: Gai Ayalon, Till Maurer
  • TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170226132
    Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Applicant: Genentech, Inc.
    Inventors: Nicholas C. Ray, Yun-Xing Cheng, Christine Edwards, Simon C. Goodacre, Wei Li, Snahel Patel, Matthew W. Cartwright, Mohammed Sajad, Po-wai Yuen, Mark E. Zak
  • Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors
    Patent number: 9724413
    Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: August 8, 2017
    Assignee: Genentech, Inc.
    Inventors: Heather Maecker, Bryan Irving
  • Anti-Ly6E antibodies and immunoconjugates and methods of use
    Patent number: 9724427
    Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: August 8, 2017
    Assignee: Genentech, Inc.
    Inventors: Chie Sakanaka, Peter Chang
  • Composition and methods for the diagnosis of immune related diseases involving the PRO52254 polypeptide
    Patent number: RE46534
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases involving detection of the PRO52254 polypeptide.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: September 5, 2017
    Assignee: Genentech, Inc.
    Inventors: Daryl T. Baldwin, Sarah C. Bodary-Winter, Andrew C. Chan, Hilary Clark, Janet K. Jackman, William I. Wood