Patents Assigned to Generics [UK] Limited
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Patent number: 9808423Abstract: The present invention provides processes for preparing suspension aerosol formulations, wherein the particles for inhalation are formed in situ during the process of manufacturing the formulation. In one aspect of the invention, a process for preparing a suspension aerosol formulation comprises the steps of: (a) dissolving one or more medicaments in one or more solvents to form a solution; and (b) mixing one or more propellants with the solution under conditions effective to precipitate, entirely or partially, at least one of the medicaments.Type: GrantFiled: October 12, 2005Date of Patent: November 7, 2017Assignee: Generics [UK] LimitedInventors: Li Li Bovet, Jay T. Holt
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Patent number: 9526790Abstract: The present invention relates to pharmaceutical compositions and in particular to suspension aerosol pharmaceutical compositions, processes to obtain them and their use in inhalation therapy.Type: GrantFiled: June 27, 2008Date of Patent: December 27, 2016Assignee: Generics [UK] LimitedInventors: Paul Flanders, James Thompson
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Patent number: 9381197Abstract: The present invention relates to the active pharmaceutical ingredient dipyridamole. In particular, it relates to efficient processes for the preparation of dipyridamole which are amenable to large scale commercial production and provide the required product with improved yield and purity. The present invention also relates to a novel crystallization method for the purification of dipyridamole.Type: GrantFiled: December 18, 2014Date of Patent: July 5, 2016Assignee: Generics [UK] LimitedInventors: Dattatrey Kokane, Bindu Manojkumar, Vinayak Govind Gore
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Patent number: 9340515Abstract: The present invention relates to processes for the preparation of erlotinib and salts and polymorphs thereof preparable by said processes, to medical uses of said erlotinib, salts and polymorphs, and to pharmaceutical compositions comprising the same.Type: GrantFiled: January 6, 2015Date of Patent: May 17, 2016Assignee: Generics (UK) LimitedInventors: Vinayak Govind Gore, Anilkumar Tripathi, Madhav Jadhav
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Patent number: 9221754Abstract: The present invention relates to two novel crystalline forms of zofenopril calcium, to processes for their preparation and their use in pharmaceutical compositions.Type: GrantFiled: September 5, 2014Date of Patent: December 29, 2015Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Priyesh Vijayakar, Ashok Pehere
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Patent number: 9181268Abstract: The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions.Type: GrantFiled: April 7, 2014Date of Patent: November 10, 2015Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Bindu Manojkumar, Dattatraya Shinde, Dattatrey Kokane
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Patent number: 9162974Abstract: The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient vorinostat. In particular it relates to a process for preparing vorinostat substantially free from impurities.Type: GrantFiled: October 6, 2014Date of Patent: October 20, 2015Assignee: Generics (UK) LimitedInventors: Vinayak G. Gore, Madhukar S. Patil, Rahul A. Bhalerao, Hemant M. Mande, Sandeep G. Mekde
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Patent number: 9150524Abstract: The present invention relates to an improved process for the preparation of Letrozole (I) and its synthetic intermediate 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III). In particular, it relates to a process to prepare Letrozole and its intermediate (III) substantially free from regioisomeric impurities. The present invention further relates to acid addition salts of 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III) such as the oxalate salt, and also to Letrozole (I), the intermediate (III) and salts thereof preparable by the processes of the present invention.Type: GrantFiled: August 26, 2011Date of Patent: October 6, 2015Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Vinay Kumar Shukla, Sandeep Mekde, Suresh Hasbe, Shreyas Bhandari, Dhananjay Shinde, Madhukar Shaligram Patil
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Publication number: 20150218126Abstract: The present invention related to crystalline forms of thalidomide having a high polymorphic purity and to processes for their preparation. The present invention also relates to pharmaceutical preparations comprising the crystalline forms for the treatment of patients suffering from autoimmune, inflammatory or angiogenic disorders.Type: ApplicationFiled: February 12, 2015Publication date: August 6, 2015Applicant: GENERICS [UK] LIMITEDInventors: Vinayak Govind Gore, Vinay Kumar Shukla, Madhukar Patil, Sandeep Mekde
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Publication number: 20150111847Abstract: The present invention relates to processes for the preparation of erlotinib and salts and polymorphs thereof preparable by said processes, to medical uses of said erlotinib, salts and polymorphs, and to pharmaceutical compositions comprising the same.Type: ApplicationFiled: January 6, 2015Publication date: April 23, 2015Applicant: GENERICS [UK] LIMITEDInventors: Vinayak Govind Gore, Anilkumar Tripathi, Madhav Jadhav
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Patent number: 8975402Abstract: The present invention relates to a new HPLC method for the analysis of the drug substance bosentan and related substances and to the use of said substances as reference standards and markers.Type: GrantFiled: November 2, 2009Date of Patent: March 10, 2015Assignee: Generics [UK] LimitedInventors: Erra Koteswara Satya Vijaya Kumar, Avinash Prabhakar Nikam
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Publication number: 20150051241Abstract: The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions.Type: ApplicationFiled: April 7, 2014Publication date: February 19, 2015Applicant: GENERICS [UK] LIMITEDInventors: Vinayak Govind GORE, Bindu MANOJKUMAR, Dattatraya SHINDE, Dattatrey KOKANE
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Patent number: 8952022Abstract: The present invention relates to processes for the preparation of erlotinib and salts and polymorphs thereof, preferably of high purity. The present invention also relates to erlotinib and salts and polymorphs thereof preparable by said processes, to medical uses of said erlotinib, salts and polymorphs, and to pharmaceutical compositions comprising the same.Type: GrantFiled: July 22, 2011Date of Patent: February 10, 2015Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Anilkumar Tripathi, Madhav Jadhav
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Patent number: 8946414Abstract: The present invention relates to the active pharmaceutical ingredient dipyridamole. In particular, it relates to efficient processes for the preparation of dipyridamole which are amenable to large scale commercial production and provide the required product with improved yield and purity. The present invention also relates to a novel crystallization method for the purification of dipyridamole.Type: GrantFiled: May 31, 2011Date of Patent: February 3, 2015Assignee: Generics [UK] LimitedInventors: Dattatrey Kokane, Bindu Manojkumar, Vinayak Govind Gore
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Patent number: 8946265Abstract: The present invention relates to improved processes for preparing 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (I) (lenalidomide) and its intermediate 3-(1-oxo-4-nitro-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione. The present invention further relates to improved processes for preparing lenalidomide crystalline form A, use of said crystalline form A as an active pharmaceutical ingredient or as an intermediate in the preparation of further crystalline or amorphous forms of lenalidomide, compositions comprising lenalidomide crystalline form A and their use in the treatment of disease.Type: GrantFiled: March 1, 2010Date of Patent: February 3, 2015Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Vinay Kumar Shukla, Shreyas Shrikant Bhandari, Suresh Hasbe
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Patent number: 8883851Abstract: The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient vorinostat. In particular it relates to a process for preparing vorinostat substantially free from impurities, involving suberic acid, aniline and hydroxylamine as starting materials.Type: GrantFiled: October 14, 2009Date of Patent: November 11, 2014Assignee: Generics [UK] LimitedInventors: Vinayak G. Gore, Madhukar S. Patil, Rahul A. Bhalerao, Hemant M. Mande, Sandeep G. Mekde
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Patent number: 8853421Abstract: The present invention relates to two novel crystalline forms of zofenopril calcium, to processes for their preparation and their use in pharmaceutical compositions.Type: GrantFiled: December 12, 2012Date of Patent: October 7, 2014Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Priyesh Vijayakar, Ashok Pehere
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Patent number: 8846916Abstract: The present invention relates to novel processes for the preparation of enantiomerically enriched ?-amino acid derivatives such as ?-amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemate with mandelic acid.Type: GrantFiled: May 10, 2010Date of Patent: September 30, 2014Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Maheshkumar Gadakar, Priyanka Bhosle, Suresh Shinde
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Publication number: 20140249175Abstract: The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions.Type: ApplicationFiled: April 7, 2014Publication date: September 4, 2014Applicant: GENERICS [UK] LIMITEDInventors: Vinayak Govind GORE, Bindu MANOJKUMAR, Dattatraya SHINDE, Dattatrey KOKANE
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Patent number: 8809589Abstract: The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline.Type: GrantFiled: July 18, 2013Date of Patent: August 19, 2014Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sinderpal Tank