Patents Assigned to Generics [UK] Limited
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Patent number: 8785461Abstract: The present invention relates to a novel intermediate useful in the preparation of bosentan and to processes for the preparation of said intermediate and bosentan. The invention further relates to compositions comprising bosentan prepared according to the processes of the invention and their use in the treatment of endothelin-receptor mediated disorders.Type: GrantFiled: February 6, 2009Date of Patent: July 22, 2014Assignee: Generics [UK] LimitedInventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Vikas Padalkar, Hemant Mande
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Patent number: 8754129Abstract: The present invention relates to crystalline forms of the active pharmaceutical ingredient vorinostat, processes for their preparation and their use in pharmaceutical compositions. Formula (I).Type: GrantFiled: November 25, 2009Date of Patent: June 17, 2014Assignee: Generics [UK] LimitedInventors: Vinayak Gore, Madhukar Patil, Rahul Bhalerao, Hemant Mande
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Publication number: 20140163241Abstract: The present invention relates to two novel crystalline forms of zofenopril calcium, to processes for their preparation and their use in pharmaceutical compositions.Type: ApplicationFiled: December 12, 2012Publication date: June 12, 2014Applicant: Generics [UK] LimitedInventors: Vinayak Gore, Priyesh Vijayakar
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Patent number: 8710241Abstract: The present invention relates to a novel anhydrous crystalline form of zofenopril calcium of formula (I), chemically known as (4S)-1-[(2S)-3-(benzoylthio)-2-methylpropionyl]-4-(phenylthio)-L-proline calcium salt or hemi-calcium salt. The present invention further relates to a process for the preparation of the new crystalline form of zofenopril calcium, its use in pharmaceutical compositions and the use of the new crystalline form and compositions in the treatment of hypertension and various other diseases.Type: GrantFiled: August 8, 2008Date of Patent: April 29, 2014Assignee: Generics [UK]LimitedInventor: Axel Becker
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Patent number: 8697719Abstract: Novel Anhydrate The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions.Type: GrantFiled: August 6, 2010Date of Patent: April 15, 2014Assignee: Generics [UK] LimitedInventors: Vinayak Govind Gore, Bindu Manojkumar, Dattatraya Shinde, Dattatrey Kokane
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Patent number: 8664390Abstract: The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.Type: GrantFiled: June 27, 2008Date of Patent: March 4, 2014Assignee: Generics (UK) LimitedInventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sandeep Mekde, Dattatraya Shinde, Prakash Bansode
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Patent number: 8648214Abstract: The present invention relates to processes for the preparation of 4-hydroxy-??-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-??-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (11), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (7), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (5), shown below, wherein X is a leaving group and Pg is a protecting group.Type: GrantFiled: April 16, 2008Date of Patent: February 11, 2014Assignee: Generics [UK] LimitedInventors: Vinayak G. Gore, Avinash C. Gaikwad, Maheshkumar Gadakar, Vinay Kumar Shukla
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Patent number: 8569545Abstract: The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline.Type: GrantFiled: June 2, 2009Date of Patent: October 29, 2013Assignee: Generics (UK) LimitedInventors: Vinayak Gore, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sinerpal Tank
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Patent number: 8530488Abstract: The present invention relates to novel crystalline forms of bosentan and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said crystalline forms and use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris.Type: GrantFiled: October 24, 2008Date of Patent: September 10, 2013Assignee: Generics [UK] LimitedInventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Prakash Bansode, Dattatraya Shinde, Sunanda Phadtare
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Publication number: 20130210842Abstract: The present invention relates to processes for the preparation of erlotinib and salts and polymorphs thereof, preferably of high purity. The present invention also relates to erlotinib and salts and polymorphs thereof preparable by said processes, to medical uses of said erlotinib, salts and polymorphs, and to pharmaceutical compositions comprising the same.Type: ApplicationFiled: July 22, 2011Publication date: August 15, 2013Applicant: GENERICS [UK] LIMITEDInventors: Vinayak Govind Gore, Anilkumar Tripathi, Madhav Jadhav
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Publication number: 20130203826Abstract: The present invention relates to an improved process for the preparation of Letrozole (I) and its synthetic intermediate 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III). In particular, it relates to a process to prepare Letrozole and its intermediate (III) substantially free from regioisomeric impurities. The present invention further relates to acid addition salts of 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III) such as the oxalate salt, and also to Letrozole (I), the intermediate (III) and salts thereof preparable by the processes of the present invention.Type: ApplicationFiled: August 26, 2011Publication date: August 8, 2013Applicant: Generics [UK] LimitedInventors: Vinayak Govind Gore, Vinay Kumar Shukla, Sandeep Mekde, Suresh Hasbe, Shreyas Bhandari, Dhananjay Shinde, Madhukar Shaligram Patil
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Publication number: 20130172587Abstract: The present invention relates to a process for the preparation of steroidal 17?-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17?-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.Type: ApplicationFiled: December 12, 2012Publication date: July 4, 2013Applicant: Generics [UK] LimitedInventor: Generics [UK] Limited
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Publication number: 20130172369Abstract: The present invention relates to the active pharmaceutical ingredient dipyridamole. In particular, it relates to efficient processes for the preparation of dipyridamole which are amenable to large scale commercial production and provide the required product with improved yield and purity. The present invention also relates to a novel crystallization method for the purification of dipyridamole.Type: ApplicationFiled: May 31, 2011Publication date: July 4, 2013Applicant: Generics (UK) LimitedInventors: Dattatrey Kokane, Bindu Manojkumar, Vinayak Govind Gore
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Publication number: 20130136795Abstract: The present invention relates to stable solid pharmaceutical compositions comprising valsartan as the active pharmaceutical ingredient. Optionally the compositions comprise one or more further active pharmaceutical ingredients. The invention further relates to methods for preparing said compositions and to the use of said compositions in the treatment or prevention of angiotensin receptor mediated disorders, in particular hypertension and related disorders.Type: ApplicationFiled: August 8, 2008Publication date: May 30, 2013Applicants: Poligono Merck, Generics [UK] LimitedInventors: Miguel Barrero, Isabel Delgado
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Patent number: 8344168Abstract: The present invention relates to a process for the preparation of steroidal 17?-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17?-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.Type: GrantFiled: December 8, 2008Date of Patent: January 1, 2013Assignee: Generics (UK) LimitedInventors: Vinayak G. Gore, Mahesh Gadakar, K. Pokharkar, V. Wakchure
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Patent number: 8288401Abstract: Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.Type: GrantFiled: May 8, 2008Date of Patent: October 16, 2012Assignee: Generics [UK] LimitedInventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Dattaatraya Shinde, Prakash Bansode
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Publication number: 20120220799Abstract: The present invention relates to a novel process for the preparation of ?-amino acids, such as (±)-3-(aminomethyl)-5-methyl-hexanoic acid 1, which is a key intermediate in the preparation of the potent anticonvulsant pregabalin, (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid 2.Type: ApplicationFiled: May 10, 2012Publication date: August 30, 2012Applicant: Generics [UK] LimitedInventors: Abhay Gaitonde, Chitra Vaidya, P. Khairnar
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Patent number: 8119662Abstract: The present invention relates to a novel crystalline form of zofenopril calcium of formula (I), chemically known as (4S)-1-[(2S)-3-(benzoylthio)-2-methylpropionyl]-4-(phenylthio)-L-proline calcium salt. The present invention further relates to a process for the preparation of the new crystalline form of zofenopril calcium and its use in pharmaceutical preparations.Type: GrantFiled: December 20, 2007Date of Patent: February 21, 2012Assignee: Generics [UK] LimitedInventors: Vinayak G. Gore, Ashok D. Pehere, Avinash C. Gaikwad, Priyesh S. Vijaykar
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Publication number: 20120029046Abstract: The present invention relates to a novel crystalline form of sunitinib free base designated form I and to processes for its preparation. The invention also relates to its use as an API and in the preparation of various forms of sunitinib. Further, the invention relates to pharmaceutical compositions comprising the novel crystalline form and salts, solvates and hydrates prepared according to the invention, and to the uses of said pharmaceutical compositions in the treatment and/or prevention of cancer.Type: ApplicationFiled: August 24, 2009Publication date: February 2, 2012Applicant: Generics (UK) LimitedInventors: Vinayak Gore, Bharati Choudhari, Mahesh Hublikar, Prakash Bansode
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Publication number: 20110275689Abstract: The present invention relates to novel intermediates and further to the use of said intermediates in processes for the preparation of indolinone derivatives, in particular 3-pyrrole substituted 2-indolinones having amide moieties on the pyrrole ring. Such compounds are useful in die treatment of abnormal cell growth, such as cancer, in mammals.Type: ApplicationFiled: July 1, 2009Publication date: November 10, 2011Applicant: GENERICS [UK] LIMITEDInventors: Abhay Gaitonde, Bharati Choudhari, Prakash Bansode, Sunanda Phadtare