Abstract: An internal gear pump or motor includes inner and outer rotors that mesh together. An internal electric motor or generator may include a stator supported by a support element that passes through bearings of the outer rotor and the inner rotor may act as a rotor of the electric motor or generator. With or without the stator, the support element may support bearings of the inner rotor. The support element may be, for example, an eccentric shaft. Fluids may be supplied via the support element, if present, for cooling, lubrication or to flush a working fluid out of portions of the pump or motor, such as bearings. Flushing may also occur via channels in the housing with or without the presence of the support element. Axial faces of one of a pair of adjacent elements, for example the inner rotor and the outer rotor, may include portions for improved axial sealing and wearing in of the other of the pair. Fluid may enter and exit chambers between the inner and outer rotors by radial ports.

Abstract: A rotating wing aircraft 1 comprises: at least one rotor blade 2; a primary gas-flow production means 7 for providing a flow of gas in an internal passage 13 of the at least one rotor blade 2; and a reserve gas-flow production means 11 for providing a flow of gas in the internal passage 13 of the at least one rotor blade 2.

Abstract: An extraction well system is disclosed that allows for isolation of electrical cables from underground mine atmosphere. The extraction well system provides for a well casing that extends downwardly proximate to an existing mine cavity and an extension casing that extends downwardly below the mine roof. In one embodiment the extension casing is external to the well casing and is attached to the well casing mechanically such as with a dual thread reducer. The extension runs from above the mine roof to below the mine floor and is perforated in the area of the mine cavity to allow liquid to drain into the bottom of the extension well. In a second embodiment, the extension casing is interior to the well casing and is attached for example by an internal liner hanger. In this embodiment, the extension casing runs from above the mine roof to below the desired minimum liquid level and it is the well casing that extends downwardly in the extension well and which is perforated to allow liquids to flow into the well.

Abstract: The present invention describes an architecture for increasing the performance of blockchain using a virtual actor model to provide stateful services that are highly scalable and responsive to events as they support publishing and/or subscribing to streaming messages and/or events. The architecture as described leverages established distributed design practices to achieve what would otherwise require costly resource intensive hardware.

Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.

Abstract: An object to provide a brake device for a caster that has a simple structure, provides reliable braking, has no risk of damaging the circumferential surface of a roller, and has high durability. The brake device for a caster includes: a plurality of projecting parts formed concentrically at regular intervals on opposite side-surfaces of a roller in a direction in parallel with the axis, and levers set across the roller at both side-panels of a fork so as to be opposed to the projecting parts, and a claw formed at a tip of each of the levers so as to be opposed to the projecting parts, wherein the levers are operated so that the claw is engaged with a concave part formed between the projecting parts, thereby locking rotation of the roller.

Abstract: Forming a 3DIC includes providing a lower device structure comprising a first substrate with a circuit layer, providing an interconnect network layer having an interconnect structure with a first coupled to a second plurality of electrodes by connection structures on a semiconductor substrate, the first plurality of electrodes being exposed on a first surface of the interconnect layer, implanting ions through the interconnect structure to form a cleave plane in the semiconductor substrate, bonding the interconnect structure to the lower device structure so that electrodes of the first plurality of electrodes are coupled to corresponding electrodes on the lower device structure, cleaving the substrate of the bonded interconnect layer at the cleave plane, removing material from the semiconductor substrate until the second plurality of electrodes is exposed, and bonding an upper device layer to the interconnect structure.

Abstract: T cell receptor (TCR) diversity of a subject, including TCR diversity in CD8+ T cell subsets, is used as a predictive indicator of responsiveness of the subject to cancer immunotherapy prior to initiation of the immunotherapy. Exemplified immunotherapy comprises administering an immune checkpoint inhibitor to a subject, wherein a TCR diversity value in CD8+ T cell subsets from the subject, such as CD8+ T cell subpopulations defined by differential cell surface marker expression, is higher than a reference value.

Abstract: The various embodiments disclosed and pictured illustrate a hammer cluster for comminuting various materials. The embodiments pictured and described herein are primarily for use with a rotatable hammermill assembly. An illustrative embodiment of a hammer cluster may include at least two hammers each having a connection portion, a contact portion, and a neck connecting the contact and connection portions. The connection portions may include a connection aperture with a relief cavity having a tab on either side thereof. A collar having a collar gap defined by two collar edges may be inserted through connection apertures of each hammer. The collar edges may engage the respective tabs such that the hammers and the collar may rotate about a rod positioned within the collar as a singular unit.

Abstract: Systems and methods herein are directed towards the separation of biologic material to obtain a target cell volume and/or cell concentration for harvesting. The target volume and/or concentration of cells may be obtained through a single cycle via three chambers, or by repeated cycles through one or more chambers to dilute the digestive enzymes used in the process and concentrate the harvestable cell volume to a predetermined target.

Abstract: An electrical connecter (400), such as a jack, has a mating end (402), a first barrel (404), an optional collar (406), a second barrel (408), a body end (410), a center receptacle (412), a first solid dielectric (502) at the mating end of the first barrel, and second solid dielectric (504) at the body end (410) of the second barrel. The first section of the barrel has a smooth and uniform outer wall (404A). This allows the inner diameter (DIS) of the first section of the barrel to be increased without reducing the thickness (T) of the first section of the barrel below a minimum value, and allows the outer diameter (DOC) of the center conductor in the vicinity of the first section of the barrel to be increased to provide for a greater current-handling capability. This provides for maintaining a desired impedance even with the greater current-handling capability.

Abstract: A system for automated processing of a plurality of batches, each batch being derived from one biological sample, the system comprising an enclosure which can be closed and sterilized, each batch of the plurality of batches comprising one or more cell processing container; a plurality of reagent containers for holding reagents within the enclosure; at least one reagent dispenser within the enclosure for dispensing reagents during said automated processing; a quality control system within the enclosure for analyzing at least one characteristic of a batch during said automated processing; a harvester within the enclosure for harvesting batches; a robotic system within the enclosure, configured for transporting cell processing containers, decapping or otherwise opening cell processing containers, pipetting reagents or liquids from cell processing containers, and aspirating liquids from cell processing containers, during said automated processing; a tracker for electronically tracking the plurality of batches aft

Abstract: A method of obtaining a pancreatic multipotent or unipotent cell including providing a cell of a first type which is not a pancreatic multipotent or unipotent cell; contacting the cell of a first type with an agent capable of remodeling the chromatin and/or DNA of the cell; transiently increasing expression of at least one pancreatic multipotent or unipotent gene regulator in the cell of a first type, to a level at which the at least one pancreatic multipotent or unipotent gene regulator is capable of driving transformation of the cell of a first type into the pancreatic multipotent or unipotent cell; and placing or maintaining the cell in a pancreatic cell culture medium and maintaining intracellular levels of the at least one pancreatic multipotent or unipotent gene regulator for a sufficient period of time to allow a pancreatic multipotent or unipotent cell to be obtained.

Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.

Abstract: The present invention discloses a surgical stapler instrument. The surgical stapler instrument comprises a handle assembly having a proximal end and a distal end. A bottom jaw is detachably coupled to the distal end of the handle assembly. The bottom jaw having a staple cartridge surface, configured to eject one or more staples. Further, a top jaw is detachably coupled to the bottom jaw toward the distal end of the handle assembly. The top jaw comprises a staple pocket disposed over an anvil surface of the top jaw and configured to bend the ejected one or more staples and deliver into targeted tissues. An effective friction coefficient (?e) of the staple pocket of the top jaw is lower than the staple cartridge surface of the bottom jaw to achieve optimized stapling.

Abstract: A permanent magnet carrier, which could be a rotor or stator of an electric machine, includes a first non-magnetic ring and a second non-magnetic ring. Between the rings are soft magnetic pole elements. The soft magnetic pole elements each connect to the first and second non-magnetic rings and the soft magnetic pole elements are separated from each other by the first and second non-magnetic rings. Permanent magnets are disposed between the soft magnetic pole elements.

Abstract: The present disclosure provides a technique whereby the influence of an endogenous TCR is eliminated in TCR gene transfer. A TCR gene is edited using a genome editing enzyme, said genome editing enzyme having one characteristic that amino acids at two specific positions in DNA-binding modules contained in a DNA-binding domain thereof show repeating patterns which differ from one module to another among the four DNA-binding modules. Thus, a lowering in the expression efficiency of the transferred TCR caused by mispairing with an endogenous TCR and the occurrence of a self-reactive TCR are avoided.

Abstract: A connection mechanism 242 of the present invention is configured such that, in a state where an inclined end surface 536 of a male connection portion 500 is brought into contact with a protruding portion 618 of a female connection portion 600, by moving the male connection portion 500 toward the female connection portion 600, the male connection portion 500 rotates and the protruding portion 618 is inserted into a guide portion 534 and a connector 532 is connected to an adapter 610. The lock mechanism 243 is configured such that the protrusion 704 of the male lock portion 700 comes in contact with a wall 858 of a circumferential recess 842 disposed in a proximal cylindrical member 806 of the female lock portion 800, and in this state, the proximal cylindrical member 806 is further moved toward a proximal fixing member 804 against an urging force of a spring 854, and then the male lock portion 700 is rotated to move to a space 856 of the circumferential recess 842.

Abstract: The present disclosure provides a technique for producing regulatory T cells specific to a desired antigen. Regulatory T cells specific to an antigen are produced by a method that includes: a step for identifying a T cell receptor (TCR) clone present in an effector T cell population specific to an antigen in an effector T cell donor; and a step for introducing all or part of the nucleic acid sequence of the TCR? gene and all or part of the nucleic acid sequence of the TCR? gene included in the clone into a regulatory T cell, said step comprising introducing the TCR? and the TCR? so as to be expressed in pairs.

Abstract: A system for timber management on a land base includes a first timber management machine; a computing device for use in the first timber management machine, a touch screen display operatively connected to the computing device for use by an operator of the first timber management machine, a geoposition determining device operatively connected to the computing device for determining position of the first timber management machine, a software application executing on the computing device, wherein the software application provides for displaying a map and a plurality of data layers on the map, wherein the map is configured to show timber bundles laid down, a current location of the first timber management machine as determined by the geoposition determining device, and a current location of a second timber management machine.