Abstract: Provided are compounds of formula (I): or a cosmeceutically acceptable or pharmaceutically acceptable salts thereof. Additionally provided are pharmaceutical and/or cosmeceutical compositions and formulations comprising the compounds and/or the cosmeceutically acceptable or pharmaceutically acceptable salts thereof, therapeutic and/or cosmetic methods using same for modulating (e.g., inhibiting) CREB binding protein (CBP)/?-catenin mediated signaling in treating skin related diseases, conditions or disorders (e.g., dermatitis, psoriasis, scarring, alopecia, etc.) mediated by aberrant CBP/?-catenin signaling, and cosmetic methods for treating skin conditions (e.g., aging, etc.) mediated by aberrant CBP/?-catenin signaling.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating data defining molecules. In one aspect, there is provided a method performed by one or more computers, the method comprising: receiving, from a user, a request to generate data identifying candidate molecules satisfying one or more molecular criteria; generating a collection of candidate molecules that satisfy the one or more molecular criteria; generating, for each candidate molecule in the collection of candidate molecules, one or more molecular scores that characterize one or more properties of the candidate molecule; filtering the collection of candidate molecules, based on the molecular scores, to remove a plurality of candidate molecules from the collection of candidate molecules; and after filtering the collection of candidate molecules based on the molecular scores, providing a representation of the collection of candidate molecules to the user.

Abstract: A cluster-supporting catalyst including porous carrier particles having acid sites, and catalyst metal clusters supported within the pores of the porous carrier particles. The catalyst metal clusters are obtained by supporting catalyst metal clusters having a positive charge, which is formed in a dispersion liquid containing a dispersion medium and the porous carrier particles dispersed in the dispersion medium, on the acid sites within the pores of the porous carrier particles through an electrostatic interaction.

Abstract: The present invention relates to a method and a system for managing an automatic evaluation model for an interview video, and a computer-readable medium.

Abstract: A biopsy marker having a spring-loaded anchor. The biopsy marker includes an insertion orientation and an anchored orientation. In the insertion orientation, the biopsy marker is manipulated under force to reduce the lateral span/cross-sectional area of the marker. In the anchored orientation, the biopsy marker is released and free to actively spring into a configuration in which the lateral span/cross-sectional area is greater than the lateral span/cross-sectional area of the biopsy marker when in the insertion orientation. In an embodiment, the spring-loaded anchor is configured to spring about a predefined rotational axis. An embodiment of the biopsy marker may be comprised of a single wire construction.

Abstract: An actuator comprising: a motor having a housing and a drive shaft, the motor arranged to rotate the drive shaft relative to the housing about a drive shaft axis; a first torque transfer device arranged to transfer torque from the drive shaft to a second shaft, the second shaft being rotatable about a second shaft axis parallel to and radially spaced from the drive shaft axis; and an output torque transfer device arranged to transfer torque from the second shaft to the housing of the motor; wherein, upon rotation of the drive shaft relative to the motor housing, the housing of the motor is arranged to rotate relative to the position of the second shaft axis.

Abstract: A biopsy marker having a spring-loaded anchor. The biopsy marker includes an insertion orientation and an anchored orientation. The lateral span/cross-sectional area of the marker is configured to change when transitioning between the insertion orientation and the anchored orientation. In an embodiment, the spring-loaded anchor is configured to spring about a predefined rotational axis. An embodiment of the biopsy marker may be comprised of a single wire construction.

Abstract: The invention provides a method for identifying an epitope sequence associated with a specific physiological state of a test subject, the method including the steps of: A) obtaining BCR and/or TCR repertoire data associated with the specific physiological state of the test subject; B) specifying a TREM sequence (repertoire specific TREM sequence) from the BCR and/or TCR repertoire data; C) obtaining a reference TREM sequence associated with the test subject; D) specifying a repertoire-reference common specific TREM sequence from the reference TREM sequence and the repertoire specific TREM sequence; and E) determining, based on the repertoire-reference common specific TREM sequence, whether a peptide sequence including the repertoire-reference common specific TREM sequence is an epitope sequence associated with the specific physiological state of the test subject.

Abstract: The present invention provides a method for producing a peptide for the treatment (in particular, immunotherapy), monitoring, or diagnosis of a disease in a subject. This method is achieved by obtaining information pertaining to a genome read, for example an exome read, of the subject and a mutation thereof, and, as necessary, information regarding the RNA sequence of the subject and information regarding the MHC type of the subject, analyzing an epitope related to the mutation on the basis of the information pertaining to the genome read (for example, the exome read) and the mutation, arbitrary information from the RNA sequence, the MHC type information, and information regarding the disease, and producing a peptide, as necessary, on the basis of information regarding the epitope.

Abstract: The present invention describes an architecture for increasing the performance of blockchain using a virtual actor model to provide stateful services that are highly scalable and responsive to events as they support publishing and/or subscribing to streaming messages and/or events. The architecture as described leverages established distributed design practices to achieve what would otherwise require costly resource intensive hardware.

Abstract: The present invention discloses a medical suture and a medical suture device, and belongs to the field of medical instruments. The medical suture comprises: a suture body, the suture body defining a longitudinal center line; and a plurality of pairs of barbs arranged at intervals along a direction of the longitudinal center line, each pair of barbs being symmetrically arranged on opposite sides of the suture body, the barb being provided with a first end connected with the suture body and a second end far away from the suture body, and a ratio of a transverse distance L1 of second ends of each pair of the barbs along a direction perpendicular to the longitudinal center line to a transverse dimension L0 of the suture body perpendicular to the direction of the longitudinal center line ranging from 1.5 to 2.5.

Abstract: A railroad tie plate placement system facilitates or enables a railroad crew to minimize interaction with railroad tie plates while placing railroad tie plates in a proper orientation on a railroad or railway track in preparation for insertion under a rail. Thus, the described railroad tie plate placement system reduces labor costs and decreases risk of injury while providing for consistent placement of tie plates.

Abstract: An apparatus, and method, for building a longevity profile, the apparatus including at least a processor and a memory communicatively connected to the at least a processor, the memory containing instructions configuring the at least a processor to receive longevity measurement data of a user, where the longevity measurement data includes at least a transcriptomic datum. The processor further configured to determine at least a longevity hallmark as a function of the longevity measurement data and generate a longevity profile of the user of the user as a function of a longevity machine-learning model, wherein the longevity machine-learning model receives the at least a longevity hallmark and the longevity measurement as inputs and outputs the longevity profile, and transmit the longevity profile to an output device.

Abstract: Described herein are reprogrammed cells, and methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming. Also described are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro reprogramming. In particular embodiments the cells are Stem-Like Cells (SLCs), including Neural Stem-Like Cells (NSLCs), Cardiac Stem-Like Cells (CSLC), Hematopoietic Stem-Like Cells (HSLC), Pancreatic Progenitor-Like Cells, and Mesendoderm-like Cells. Also described are methods for generating these cells from human somatic cells and other types of cells. Also provided are compositions and methods of using of the cells so generated in human therapy and in other areas.

Abstract: A cluster-supporting catalyst including porous carrier particles having acid sites, and catalyst metal clusters supported within the pores of the porous carrier particles. In the cluster-supporting catalyst including porous carrier particles having acid sites, and catalyst metal clusters supported within the pores of the porous carrier particles, the catalyst metal may be rhodium, the catalyst metal may be palladium, the catalyst metal may be platinum, or the catalyst metal may be copper.

Abstract: An internal gear pump or motor includes inner and outer rotors that mesh together. An internal electric motor or generator may include a stator supported by a support element that passes through bearings of the outer rotor and the inner rotor may act as a rotor of the electric motor or generator. With or without the stator, the support element may support bearings of the inner rotor. The support element may be, for example, an eccentric shaft. Fluids may be supplied via the support element, if present, for cooling, lubrication or to flush a working fluid out of portions of the pump or motor, such as bearings. Flushing may also occur via channels in the housing with or without the presence of the support element. Axial faces of one of a pair of adjacent elements, for example the inner rotor and the outer rotor, may include portions for improved axial sealing and wearing in of the other of the pair. Fluid may enter and exit chambers between the inner and outer rotors by radial ports.

Abstract: An extraction well system is disclosed that allows for isolation of electrical cables from underground mine atmosphere. The extraction well system provides for a well casing that extends downwardly proximate to an existing mine cavity and an extension casing that extends downwardly below the mine roof. In one embodiment the extension casing is external to the well casing and is attached to the well casing mechanically such as with a dual thread reducer. The extension runs from above the mine roof to below the mine floor and is perforated in the area of the mine cavity to allow liquid to drain into the bottom of the extension well. In a second embodiment, the extension casing is interior to the well casing and is attached for example by an internal liner hanger. In this embodiment, the extension casing runs from above the mine roof to below the desired minimum liquid level and it is the well casing that extends downwardly in the extension well and which is perforated to allow liquids to flow into the well.

Abstract: A rotating wing aircraft 1 comprises: at least one rotor blade 2; a primary gas-flow production means 7 for providing a flow of gas in an internal passage 13 of the at least one rotor blade 2; and a reserve gas-flow production means 11 for providing a flow of gas in the internal passage 13 of the at least one rotor blade 2.

Abstract: The present invention describes an architecture for increasing the performance of blockchain using a virtual actor model to provide stateful services that are highly scalable and responsive to events as they support publishing and/or subscribing to streaming messages and/or events. The architecture as described leverages established distributed design practices to achieve what would otherwise require costly resource intensive hardware.