Patents Assigned to Genetics Institute, LLC
  • ICE/CED-3 like protease designated FMH-1
    Patent number: 6586225
    Abstract: Polynucleotides encoding novel proteases designated “FMH-1” are disclosed. Host cells transformed with such polynucleotides and methods for making FMH-1 proteases are also disclosed. The invention also provides FMH-1 proteases and antibodies that react with them, along with pharmaceutical compositions comprising FMH-1 proteases or polynucleotides encoding FMH-1 proteases. Methods for treating conditions associated with excessive or insufficient apoptosis by administering such pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: July 1, 2003
    Assignee: Genetics Institute, LLC
    Inventor: Michael R. Bowman
  • Inhibitors of phospholipase enzymes
    Patent number: 6500853
    Abstract: This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined in the specification.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: December 31, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang, Lihren Chen, John L. Knopf
  • Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
    Patent number: 6492493
    Abstract: Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: December 10, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Anthony J. Celeste, Beth L. Murray
  • Crystalline IL-6 and models of the molecular structure of IL-6
    Patent number: 6461604
    Abstract: Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antagonists of such interactions. Crystalline human IL-6 is also provided.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: October 8, 2002
    Assignee: Genetics Institute, LLC
    Inventors: William S. Somers, Mark L. Stahl, Jasbir S. Seehra, Guang-Yi Xu, Thomas E. McDonagh, Hsiang-Ai Yu, Jin Hong
  • Secreted proteins
    Patent number: 6451318
    Abstract: Novel proteins are disclosed.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: September 17, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. La Vallie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Megakaryocyte stimulating factors
    Patent number: 6433142
    Abstract: Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.
    Type: Grant
    Filed: September 10, 1991
    Date of Patent: August 13, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Katherine Turner, Steven C. Clark, Kenneth Jacobs, Rodney M. Hewick, Thomas G. Gesner