Patents Assigned to Genetics Institute
  • Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same
    Patent number: 6801860
    Abstract: The present invention provides for crystalline cPLA2. The crystal structure of cPLA2 has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of cPLA2 activity and membrane binding using such models are also disclosed.
    Type: Grant
    Filed: February 15, 1999
    Date of Patent: October 5, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Andrea Dessen, William S. Somers, Mark L. Stahl, Jasbir S. Seehra
  • Methods and compositions for healing and repair of articular cartilage
    Publication number: 20040192605
    Abstract: Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional repair of articular cartilage tissue.
    Type: Application
    Filed: February 18, 2004
    Publication date: September 30, 2004
    Applicant: Genetics Institute, LLC
    Inventors: Renwen Zhang, Diane Peluso, Elisabeth Morris
  • DNA encoding human JE cytokine
    Patent number: 6787645
    Abstract: A novel human cytokine, JE factor, and processes for producing it are disclosed. JE may be used in pharmaceutical preparations for stimulating and/or enhancing immune responsiveness and in wound healing and related tissue repair. containing the factor.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: September 7, 2004
    Assignees: Dana-Farber Cancer Institute, Inc., Genetics Institute
    Inventors: Barrett J. Rollins, Charles D. Stiles, Gordon G. Wong
  • Use of interleukin-11 to treat gastrointestinal disorders
    Publication number: 20040161406
    Abstract: The use of interleukin-11 to prevent, to ameliorate, and to treat a gastrointestinal disorder in a mammal in need of such treatment is disclosed.
    Type: Application
    Filed: February 10, 2004
    Publication date: August 19, 2004
    Applicants: Genetics Institute, LLC, Catholic University
    Inventors: James C. Keith, Theo L. Peeters, Inge Depoortere, G. Van Asche
  • Tendon-inducing compositions
    Publication number: 20040146923
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Application
    Filed: February 18, 2004
    Publication date: July 29, 2004
    Applicants: Genetics Institute, LLC, President and Fellows of Harvard College
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Receptor proteins
    Publication number: 20040142417
    Abstract: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.
    Type: Application
    Filed: June 23, 2003
    Publication date: July 22, 2004
    Applicant: Genetics Institute, LLC.
    Inventors: John M. Wozney, Anthony J. Celeste, R. Scott Thies, Noboru Yamaji
  • Methods of preventing immune-mediated abortion by inhibiting a CD28-mediated costimulatory signal
    Publication number: 20040126781
    Abstract: Method of inhibiting and diagnosing spontaneous abortion in a subject are provided. The subject methods are based, inter alia, on the administration of an agent that inhibits a costimulatory signal in a T cell such that spontaneous abortion in the subject is inhibited. The subject methods are also based on the levels of adhesion molecules, inflammatory cytokines, and immune cell surface molecules which are altered in spontaneous abortion.
    Type: Application
    Filed: June 27, 2003
    Publication date: July 1, 2004
    Applicant: GENETICS INSTITUTE, INC.
    Inventors: Vincent Ling, Gary S. Gray, James C. Keith, Srinivas Maganti
  • Cloning of enterokinase and method of use
    Patent number: 6746859
    Abstract: Provided are nucleic acid sequence sequences encoding enterokinase activity, the expression products thereof, and methods for using same.
    Type: Grant
    Filed: February 3, 1997
    Date of Patent: June 8, 2004
    Assignee: Genetics Institute, LLC
    Inventor: Edward R. LaVallie
  • Methods for producing factor VIII proteins
    Publication number: 20040087776
    Abstract: Methods are provided for purification of Factor VIII polypeptides by immunoaffinity chromatography and ion exchange chromatography, in which the eluate from the immunoaffinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The methods result in improved purification without significant yield loss.
    Type: Application
    Filed: December 3, 2003
    Publication date: May 6, 2004
    Applicant: Genetics Institute, LLC
    Inventors: Brian D. Kelley, Suresh Vunnum, Johanna Dalborg, Anna Petersson
  • Inhibition of stenosis or restenosis by P-selectin ligand antagonists
    Publication number: 20040086519
    Abstract: The present invention relates to methods and compositions for the modulation of restenosis and stenosis characterized by constrictive vascular remodeling and neointimal formation, in a subject, by administering a P-selectin antagonist. The invention further provides methods for modulating leukocyte recruitment, cell to cell adhesion, and cell adhesion to blood vessels in a subject by administering soluble P-selectin ligand, an anti-P-selectin ligand antibody, or an anti-P-selectin antibody. The invention also provides methods for identifying compounds capable of modulating restenosis.
    Type: Application
    Filed: May 7, 2003
    Publication date: May 6, 2004
    Applicants: Genetics Institute, LLC, Montreal Heart Institute of Montreal
    Inventors: Anjali Kumar, Robert G. Schaub, Jean-Francois Tanguay, Yahye Merhi
  • Primers-attached vector elongation (PAVE): a 5?-directed cDNA cloning strategy
    Patent number: 6730481
    Abstract: A novel method for preparing cDNA libraries is disclosed.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: May 4, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Chuanzheng Song, Julie C. Brown, Wu Leeying, Daniel S. Rivera
  • Methods and compositions for healing and repair of articular cartilage
    Patent number: 6727224
    Abstract: Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional repair of articular cartilage tissue.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: April 27, 2004
    Assignee: Genetics Institute, LLC.
    Inventors: Renwen Zhang, Diane Peluso, Elisabeth Morris
  • Use of interleukin-11 to treat gastrointestinal disorders
    Patent number: 6723314
    Abstract: The use of interleukin-11 to prevent, to ameliorate, and to treat a gastrointestinal disorder in a mammal in need of such treatment is disclosed.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: April 20, 2004
    Assignees: Genetics Institute, LLC, Catholic University
    Inventors: James C. Keith, Jr., Theo L. Peeters, Inge Depoortere, G. Van Asche
  • Tendon-inducing compositions
    Patent number: 6719968
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: April 13, 2004
    Assignee: Genetics Institute, LLC.
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Vaccine adjuvants for immunotherapy of melanoma
    Patent number: 6716422
    Abstract: The invention provides methods of inducing the production of cytolytic T lymphocytes directed against malignancy or infectious agent by a mammal and treating such disease such that deleterious side effects are minimized and treatment of metastatic melanomas are surprisingly and dramatically improved.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: April 6, 2004
    Assignees: ARCH Development Corporation, Genetics Institute Incorporated
    Inventors: Thomas F. Gajewski, Francesca Fallarino
  • Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y
    Patent number: 6706264
    Abstract: Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-&ggr; or TNF-&agr;. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: March 16, 2004
    Assignee: Genetics Institute, LLC
    Inventors: John Leonard, Samuel Goldman, Richard O'Hara, Jr.
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20040038276
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: July 8, 2003
    Publication date: February 26, 2004
    Applicant: GENETICS INSTITUTE, LLC.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert J. Steininger, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
  • Aggrecanase molecules
    Patent number: 6689599
    Abstract: Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: February 10, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
  • Methods for producing factor VIII proteins
    Patent number: 6683159
    Abstract: Methods are provided for purification of Factor VIII polypeptides by immunoaffinity chromatography and ion exchange chromatography, in which the eluate from the immunoaffinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The methods result in improved purification without significant yield loss.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: January 27, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Brian D. Kelley, Suresh Vunnum, Johanna Dalborg, Anna Petersson
  • Human GDP-mannose 4,6 dehydratase
    Publication number: 20030235572
    Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
    Type: Application
    Filed: June 11, 2001
    Publication date: December 25, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Francis Sullivan, Ronald Kriz, Ravindra Kumar