Patents Assigned to Genetics Institute
  • Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
    Patent number: 6593109
    Abstract: The present invention relates to a methods for producing recombinant heterodimeric BMP proteins useful in the field of treating bone defects, healing bone injury and in wound healing in general. The invention also relates to the recombinant heterodimers and compositions containing them.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: July 15, 2003
    Assignee: Genetics Institute, Inc.
    Inventors: David Israel, Neil M. Wolfman
  • Novel interleukin-1 receptor intracellular ligand proteins and inhibitors of ligand binding
    Publication number: 20030124625
    Abstract: Novel IL-1-R intracellular ligand proteins are disclosed. Polynucleotides encoding the IL-1-R intracellular ligand protein are also disclosed, along with vectors, host cells, and methods of making the IL-1-R intracellular ligand protein. Pharmaceutical compositions containing the IL-1-R intracellular ligand protein, methods of treating inflammatory conditions, and methods of inhibiting IL-1-R intracellular domain binding are also disclosed. Methods of identifying inhibitors of IL-1-R intracellular domain binding and inhibitors identified by such methods are also disclosed.
    Type: Application
    Filed: June 18, 2001
    Publication date: July 3, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: James Graham, Lih-Ling Lin
  • Cytosolic phospholipase A2-beta enzymes
    Publication number: 20030124702
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A2-Beta enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Application
    Filed: October 7, 2002
    Publication date: July 3, 2003
    Applicant: Genetics Institute L.L.C.
    Inventors: Ronald Kriz, Chuanzheng Song
  • ICE/CED-3 like protease designated FMH-1
    Patent number: 6586225
    Abstract: Polynucleotides encoding novel proteases designated “FMH-1” are disclosed. Host cells transformed with such polynucleotides and methods for making FMH-1 proteases are also disclosed. The invention also provides FMH-1 proteases and antibodies that react with them, along with pharmaceutical compositions comprising FMH-1 proteases or polynucleotides encoding FMH-1 proteases. Methods for treating conditions associated with excessive or insufficient apoptosis by administering such pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: July 1, 2003
    Assignee: Genetics Institute, LLC
    Inventor: Michael R. Bowman
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20030100053
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: October 30, 2001
    Publication date: May 29, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. La Vallie, Lisa A. Racie, Cheryl Evans, David Merberg, Sha Mi, Maurice Treacy
  • Neuronal uses of BMP-11
    Publication number: 20030083252
    Abstract: Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.
    Type: Application
    Filed: December 20, 2001
    Publication date: May 1, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Anthony J. Celeste, John M. Wozney, R. Scott Thies
  • Polymorphic elements in the costimulatory receptor locus and uses thereof
    Publication number: 20030054371
    Abstract: The invention relates to polymorphic markers within the costimulatory receptor gene locus. These markers are characterized by sets of oligonucleotide primers according to the invention useful in PCR amplification and DNA segment resolution.
    Type: Application
    Filed: February 27, 2002
    Publication date: March 20, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Vincent Ling, Paul Wu, Gary S. Gray
  • Isotope-coded ionization-enhancing reagents (ICIER) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry
    Publication number: 20030054570
    Abstract: Arginine-containing cysteine-modifying compounds useful for MALDI-MS analysis of proteins are provided. These compounds termed isotope-coded ionization enhancement reagents (ICIER) can provide ionization enhancement in MALDI-MS, relative quantitation, and additional database searching constraints at the same time without any extra sample manipulation. More specifically, ICIER increase the ionization efficiency of cysteine-containing peptides by attachment of a guanidino functional group. ICIER also increase the overall hydrophilicity of these peptides due to the hydrophilic nature of ICIER and thus increase the percentage of recovery of these peptides during sample handling and processing such as in-gel digestion or liquid chromatography.
    Type: Application
    Filed: October 22, 2001
    Publication date: March 20, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Yongchang Qiu, Jack H. Wang, Rodney M. Hewick
  • Methods for selectively stimulating proliferation of T cells
    Patent number: 6534055
    Abstract: Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: March 18, 2003
    Assignee: Genetics Institute, Inc.
    Inventors: Carl H. June, Craig B. Thompson, Gary J. Nabel, Gary S. Gray, Paul D. Rennert
  • Novel BMP products
    Publication number: 20030049826
    Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Application
    Filed: March 9, 2001
    Publication date: March 13, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki A. Rosen
  • DNA encoding human interleukin-11 receptor
    Patent number: 6528281
    Abstract: Polynucleotides encoding the human IL-11 receptor and fragments thereof are disclosed. IL-11 receptor proteins, methods for their production, inhibitors of binding of human IL-11 and its receptor and methods for their identification are also disclosed.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: March 4, 2003
    Assignee: Genetics Institute, Inc.
    Inventor: James Tobin
  • GL50 nucleic acids and uses therefor
    Patent number: 6521749
    Abstract: The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GL50 gene has been introduced or disrupted. The invention still further provides isolated GL50 polypeptides, fusion proteins, antigenic peptides and anti-GL50 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: February 18, 2003
    Assignee: Genetics Institute, Inc.
    Inventors: Vincent Ling, Kyriaki Dunussi-Joannopoulos
  • Novel P-selectin ligand protein
    Publication number: 20030018181
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Application
    Filed: August 21, 2001
    Publication date: January 23, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • Treatment of Kaposi's sarcoma with IL-12
    Patent number: 6509321
    Abstract: Methods are provided for using IL-12 to treat Kaposi's sarcoma (KS), particularly AIDS-associated KS.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: January 21, 2003
    Assignee: Genetics Institute, Inc.
    Inventors: Robert Yarchoan, James M. Pluda, Kathleen Wyvill, Jill Lietzau, Gene M. Shearer, Ellen Feigal, Giovanna Tosato, Richard Little, Matthew L. Sherman
  • Primers-attached vector elongation (PAVE): a 5'-directed CDNA cloning strategy
    Publication number: 20030008298
    Abstract: A novel method for preparing cDNA libraries is disclosed.
    Type: Application
    Filed: November 5, 2001
    Publication date: January 9, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Chuanzheng Song, Julie C. Brown, Wu Leeying, Daniel S. Rivera
  • Inhibitors of phospholipase enzymes
    Patent number: 6500853
    Abstract: This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined in the specification.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: December 31, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang, Lihren Chen, John L. Knopf
  • Secreted protein, BA3.1, and polynucleotides encoding same
    Publication number: 20020192779
    Abstract: A novel secreted protein, BA3.1, is disclosed. Polynucleotides encoding BA3.1 are also provided.
    Type: Application
    Filed: January 7, 2002
    Publication date: December 19, 2002
    Applicant: Genetics Institute, Inc.
    Inventor: Michael Bowman
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020193567
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: April 2, 2002
    Publication date: December 19, 2002
    Applicant: Genetics institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael R. Bowman, Vikki Spaulding, McKeough Carlin-Duckett, Kerry Kelleher
  • Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
    Patent number: 6492493
    Abstract: Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: December 10, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Anthony J. Celeste, Beth L. Murray
  • Cytosolic phospholipase A2-beta enzymes
    Patent number: 6482625
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A2-Beta enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: November 19, 2002
    Assignee: Genetics Institute, L.L.C.
    Inventors: Ronald Kriz, Chuanzheng Song