Patents Assigned to GenMark Diagnostics, Inc.
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Publication number: 20210246491Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: ApplicationFiled: April 28, 2021Publication date: August 12, 2021Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey, Michael Thomas Nguyen
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Publication number: 20210181219Abstract: A pathogen detection device is provided. The pathogen detection device may include a pathogen detector circuit configured to detect a target analyte in a patient sample, determine the presence of a pathogen from the target analyte, and generate a detection result including the identity of the pathogen and resistance genes (if any); and a decision support generator circuit configured to generate decision support information for the pathogen by application of user configurable rules to the detection result, wherein each of the configurable rules include a logic expression that indicates the corresponding decision support information of the rule to be included in the detection report.Type: ApplicationFiled: January 26, 2021Publication date: June 17, 2021Applicant: GenMark Diagnostics, Inc.Inventors: Michael Thomas Nguyen, Margaret Ginzburg, Shawn Andre Hall, Lisa M. Filippone
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Publication number: 20210172898Abstract: Disclosed are methods of measuring moisture. Specifically, methods of measuring moisture on dry or nearly dry surfaces using an electrochemical sensor are disclosed. The method comprises applying a coating comprising an electrolyte to an electrode wherein water in the air can permeate the coating, applying a voltage to the electrode, detecting a current and, determining if the current indicates the presence of moisture. As a voltage is applied, oxygen in the water is reduced and produces a measurable signal. The method includes measuring the amount of or decrease of dissolved oxygen (in the form of water) at the surface of the electrode over time. Reduction of oxygen acts as a surrogate for water/moisture and, as such, the dryness of the surface of the electrode is calculated based on a predetermined relationship between current and dissolved oxygen (in the form of water).Type: ApplicationFiled: January 27, 2021Publication date: June 10, 2021Applicant: GenMark Diagnostics, Inc.Inventor: Christopher E. Uhegbu
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Publication number: 20210147917Abstract: This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.Type: ApplicationFiled: January 8, 2021Publication date: May 20, 2021Applicant: GenMark Diagnostics, Inc.Inventors: Jon Faiz Kayyem, Jayashankar Srinivasan, Sean Ford
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Patent number: 10948450Abstract: Disclosed are methods of measuring moisture. Specifically, methods of measuring moisture on dry or nearly dry surfaces using an electrochemical sensor are disclosed. The method comprises applying a coating comprising an electrolyte to an electrode wherein water in the air can permeate the coating, applying a voltage to the electrode, detecting a current and, determining if the current indicates the presence of moisture. As a voltage is applied, oxygen in the water is reduced and produces a measurable signal. The method includes measuring the amount of or decrease of dissolved oxygen (in water) at the surface of the electrode over time. Reduction of oxygen acts as a surrogate for water/moisture and, as such, the dryness of the surface of the electrode is calculated based on a predetermined relationship between current and dissolved oxygen (in water). The method is also adapted to measure other target chemicals in a coating.Type: GrantFiled: July 23, 2018Date of Patent: March 16, 2021Assignee: GenMark Diagnostics, Inc.Inventor: Christopher E. Uhegbu
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Publication number: 20210060566Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: November 11, 2020Publication date: March 4, 2021Applicant: GenMark Diagnostics, Inc.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Patent number: 10935561Abstract: A pathogen detection device is provided. The pathogen detection device may include a pathogen detector circuit configured to detect a target analyte in a patient sample, determine the presence of a pathogen from the target analyte, and generate a detection result including the identity of the pathogen and resistance genes (if any); and a decision support generator circuit configured to generate decision support information for the pathogen by application of user configurable rules to the detection result, wherein each of the configurable rules include a logic expression that indicates the corresponding decision support information of the rule to be included in the detection report.Type: GrantFiled: June 1, 2018Date of Patent: March 2, 2021Assignee: GenMark Diagnostics, Inc.Inventors: Michael Thomas Nguyen, Margaret Ginzburg, Shawn Andre Hall, Lisa M. Filippone
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Patent number: 10864522Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: GrantFiled: August 15, 2019Date of Patent: December 15, 2020Assignee: GenMark Diagnostics, Inc.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Publication number: 20200332346Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.Type: ApplicationFiled: April 24, 2020Publication date: October 22, 2020Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey
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Patent number: 10807090Abstract: An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include a piercing point for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.Type: GrantFiled: August 3, 2016Date of Patent: October 20, 2020Assignee: GenMark Diagnostics, Inc.Inventors: David Walter Wright, Dominic Aiello
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Publication number: 20200300846Abstract: The invention, depending on aspect and embodiment, relates to capture probe controls, and capture and signal probe configurations and combinations of configurations that can facilitate accurate and efficient multiplex analyte detection, especially in electrochemical detection schemes.Type: ApplicationFiled: April 28, 2020Publication date: September 24, 2020Applicant: GenMark Diagnostics, Inc.Inventors: Michael Leonard Wood, Aviva Ruth Jacobs
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Patent number: 10753986Abstract: Disclosed are devices, systems and methods for assessing the integrity of electrical connections between elements of interfacing electronic devices. In some aspects, a system includes an analysis device having electronics that interface with an assay cartridge inserted into the analysis device, wherein the analysis device is configured to conduct a preflight test in which impedance values for each circuit between the assay cartridge and analysis device are rearranged and assessed to determine the electrical connection integrity of the assay cartridge to the analysis device prior to implementing the assay.Type: GrantFiled: November 26, 2019Date of Patent: August 25, 2020Assignee: GENMARK DIAGNOSTICS, INC.Inventors: Roger Harry Taylor, John B. Gorman, Tyler David Jensen
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Patent number: 10670591Abstract: The invention, depending on aspect and embodiment, relates to capture probe controls, and capture and signal probe configurations and combinations of configurations that can facilitate accurate and efficient multiplex analyte detection, especially in electrochemical detection schemes.Type: GrantFiled: May 8, 2018Date of Patent: June 2, 2020Assignee: GenMark Diagnostics, Inc.Inventors: Michael Leonard Wood, Aviva Ruth Jacobs
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Publication number: 20200156065Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: August 15, 2019Publication date: May 21, 2020Applicant: GenMark Diagnostics, Inc.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Publication number: 20200147603Abstract: A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument.Type: ApplicationFiled: January 9, 2020Publication date: May 14, 2020Applicant: GenMark Diagnostics, Inc.Inventors: Brad Frederick Tieman, Scott Corey
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Patent number: 10564211Abstract: Disclosed are devices, systems and methods for assessing the integrity of electrical connections between elements of interfacing electronic devices. In some aspects, a system includes an analysis device having electronics that interface with an assay cartridge inserted into the analysis device, wherein the analysis device is configured to conduct a preflight test in which impedance values for each circuit between the assay cartridge and analysis device are rearranged and assessed to determine the electrical connection integrity of the assay cartridge to the analysis device prior to implementing the assay.Type: GrantFiled: June 21, 2019Date of Patent: February 18, 2020Assignee: GENMARK DIAGNOSTICS, INC.Inventor: Roger Harry Taylor
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Publication number: 20200025708Abstract: Disclosed are methods of measuring moisture. Specifically, methods of measuring moisture on dry or nearly dry surfaces using an electrochemical sensor are disclosed. The method comprises applying a coating comprising an electrolyte to an electrode wherein water in the air can permeate the coating, applying a voltage to the electrode, detecting a current and, determining if the current indicates the presence of moisture. As a voltage is applied, oxygen in the water is reduced and produces a measurable signal. The method includes measuring the amount of or decrease of dissolved oxygen (in the form of water) at the surface of the electrode over time. Reduction of oxygen acts as a surrogate for water/moisture and, as such, the dryness of the surface of the electrode is calculated based on a predetermined relationship between current and dissolved oxygen (in the form of water).Type: ApplicationFiled: July 23, 2018Publication date: January 23, 2020Applicant: GenMark Diagnostics, Inc.Inventor: Christopher E. UHEGBU
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Publication number: 20190369126Abstract: A pathogen detection device is provided. The pathogen detection device may include a pathogen detector circuit configured to detect a target analyte in a patient sample, determine the presence of a pathogen from the target analyte, and generate a detection result including the identity of the pathogen and resistance genes (if any); and a decision support generator circuit configured to generate decision support information for the pathogen by application of user configurable rules to the detection result, wherein each of the configurable rules include a logic expression that indicates the corresponding decision support information of the rule to be included in the detection report.Type: ApplicationFiled: June 1, 2018Publication date: December 5, 2019Applicant: GenMark Diagnostics, Inc.Inventors: Michael Thomas Nguyen, Margaret Ginzburg, Shawn Andre Hall, Lisa M. Filippone
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Patent number: D881409Type: GrantFiled: October 27, 2017Date of Patent: April 14, 2020Assignee: GenMark Diagnostics, Inc.Inventors: Jon Faiz Kayyem, Tyler David Jensen, Bradford Frederick Tieman, Darren S Gray, Sean Ford, Dominic Aiello, Peter Kroehl
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Patent number: D900330Type: GrantFiled: January 2, 2019Date of Patent: October 27, 2020Assignee: GenMark Diagnostics, Inc.Inventors: Jon Faiz Kayyem, Matthew Sean Thomas, Mathieu Dominic Turpault, Christopher John Murray