Patents Assigned to GenMark Diagnostics, Inc.
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Publication number: 20180095100Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.Type: ApplicationFiled: September 19, 2017Publication date: April 5, 2018Applicant: GENMARK DIAGNOSTICS, INC.Inventors: Michael Thomas NGUYEN, Sean FORD, Nikolas James HANSEN
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Patent number: 9891215Abstract: The present invention provides compositions and methods directed to an electrode initialization step for the electrochemical treatment of monolayers used in electrochemical detection of target analytes on the surface of a monolayer. Electrode initialization creates a more stable monolayer, and resolves variability within the electrochemical signal detected on the monolayer.Type: GrantFiled: March 18, 2014Date of Patent: February 13, 2018Assignee: GENMARK DIAGNOSTICS, INC.Inventors: Jon Faiz Kayyem, Ken Rusterholz, William Bender, Sean Ford, Claudia C. Argueta
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Patent number: 9598722Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: GrantFiled: November 11, 2014Date of Patent: March 21, 2017Assignee: GENMARK DIAGNOSTICS, INC.Inventors: David Walter Wright, Dominic Aiello, Peter Kroehl, Jon Faiz Kayyem, Darren Scott Gray
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Publication number: 20170036207Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: October 20, 2016Publication date: February 9, 2017Applicant: GENMARK DIAGNOSTICS, INC.Inventors: DAVID WALTER WRIGHT, DOMINIC AIELLO, PETER KROEHL, JON FAIZ KAYYEM, DARREN SCOTT GRAY
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Publication number: 20170036210Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: October 20, 2016Publication date: February 9, 2017Applicant: GENMARK DIAGNOSTICS, INC.Inventors: SCOTT COREY, BRIAN MURPHY, ERIC SCHNEIDER, DAVID WALTER WRIGHT, DOMINIC AIELLO, ANDREW FISH, JAY SRINIVASAN, GEORGE MALTEZOS
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Publication number: 20170021349Abstract: A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument.Type: ApplicationFiled: October 7, 2016Publication date: January 26, 2017Applicant: GENMARK DIAGNOSTICS, INC.Inventors: BRAD FREDERICK TIEMAN, SCOTT COREY
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Publication number: 20160339426Abstract: An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include piercing means for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.Type: ApplicationFiled: August 3, 2016Publication date: November 24, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: DAVID WALTER WRIGHT, DOMINIC AIELLO
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Patent number: 9500663Abstract: A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument.Type: GrantFiled: November 11, 2014Date of Patent: November 22, 2016Assignee: GENMARK DIAGNOSTICS, INC.Inventors: Brad Frederick Tieman, Scott Corey
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Patent number: 9498778Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: GrantFiled: November 11, 2014Date of Patent: November 22, 2016Assignee: GENMARK DIAGNOSTICS, INC.Inventors: Scott Corey, Brian Murphy, Eric Schneider, David Walter Wright, Dominic Aiello, Andrew Fish, Jay Srinivasan, George Maltezos
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Publication number: 20160297570Abstract: An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.Type: ApplicationFiled: June 16, 2016Publication date: October 13, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: David Walter WRIGHT, Dominic AIELLO, Robert CLARK
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Patent number: 9453613Abstract: An apparatus configured for displacing fluid from a fluid container comprises first and second actuators configured to be movable together until the first actuator compresses a first part of the fluid container and then moveable independently until the second actuator compresses a second part of the fluid container. Fluid containers comprise a first vessel, a second vessel, and a sealing partition preventing fluid flow from the second vessel and further include piercing means for piercing the sealing partition to permit fluid flow from the second vessel. A fluid container comprises a vessel configured to be collapsed to displace fluid from the vessel, a housing surrounding at least a portion of the vessel, and a floating compression plate movably disposed within the housing and configured to permit an external actuator to press the compression plate into the vessel to collapse the vessel and displace the fluid contents therefrom.Type: GrantFiled: March 12, 2014Date of Patent: September 27, 2016Assignee: GENMARK DIAGNOSTICS, INC.Inventors: David Walter Wright, Dominic Aiello
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Publication number: 20160236191Abstract: A module for processing fluids includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers to collapse each fluid chamber by compressing the fluid chamber between the compression element and the substrate as the compression element moves over the fluid chamber.Type: ApplicationFiled: September 30, 2014Publication date: August 18, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventor: David Walter WRIGHT
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Patent number: 9410663Abstract: An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.Type: GrantFiled: March 12, 2014Date of Patent: August 9, 2016Assignee: GENMARK DIAGNOSTICS, INC.Inventors: David Walter Wright, Dominic Aiello, Robert Clark
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Publication number: 20160158743Abstract: A fluid container comprises a first vessel, a second vessel connected or connectable to the first vessel, and a sealing partition preventing fluid flow from the second vessel.Type: ApplicationFiled: November 23, 2015Publication date: June 9, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: DAVID WALTER WRIGHT, DOMINIC AIELLO
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Publication number: 20160129445Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: November 11, 2014Publication date: May 12, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: SCOTT COREY, BRIAN MURPHY, ERIC SCHNEIDER, DAVID WALTER WRIGHT, DOMINIC AIELLO, ANDREW FISH, JAY SRINIVASAN, GEORGE MALTEZOS
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Publication number: 20160129437Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: November 11, 2014Publication date: May 12, 2016Applicants: ADVANCED LIQUID LOGIC, INC., GENMARK DIAGNOSTICS, INC.Inventors: JON FAIZ KAYYEM, SEAN FORD, VAMSEE K. PAMULA, VIJAY SRINIVASAN, SCOTT COREY, BRIAN MURPHY, DAVID WALTER WRIGHT, DOMINIC AIELLO
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Publication number: 20160130640Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.Type: ApplicationFiled: November 11, 2014Publication date: May 12, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: DAVID WALTER WRIGHT, DOMINIC AIELLO, PETER KROEHL, JON FAIZ KAYYEM, DARREN SCOTT GRAY
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Publication number: 20160131672Abstract: A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument.Type: ApplicationFiled: November 11, 2014Publication date: May 12, 2016Applicant: GENMARK DIAGNOSTICS, INC.Inventors: BRAD FREDERICK TIEMAN, SCOTT COREY
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Patent number: 9222623Abstract: A fluid container comprises a first vessel, a second vessel connected or connectable to the first vessel, and a sealing partition preventing fluid flow from the second vessel. The container further includes a spherical opening element initially supported within the second vessel by the sealing partition and configured to be contacted with the sealing partition to open the sealing partition and permit fluid flow from the second vessel.Type: GrantFiled: March 12, 2014Date of Patent: December 29, 2015Assignee: GENMARK DIAGNOSTICS, INC.Inventors: David Walter Wright, Dominic Aiello
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Publication number: 20150323555Abstract: This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.Type: ApplicationFiled: July 23, 2015Publication date: November 12, 2015Applicant: GENMARK DIAGNOSTICS, INC.Inventors: JON FAIZ KAYYEM, JAYASHANKAR SRINIVASAN, SEAN FORD