Patents Assigned to GENO LLC
-
Publication number: 20180311460Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.Type: ApplicationFiled: April 30, 2018Publication date: November 1, 2018Applicant: GENO LLCInventors: David R. Rounbehler, David H. Fine
-
Patent number: 9956373Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.Type: GrantFiled: September 1, 2014Date of Patent: May 1, 2018Assignee: GENO LLCInventors: David P. Rounbehler, David H. Fine
-
Publication number: 20180071467Abstract: An apparatus for delivering NO includes a nitric oxide-releasing agent, a reactor cartridge containing a reducing agent that coverts a nitric oxide-releasing agent to nitric oxide (NO), a portable console, and a respiratory assist device configured to deliver the NO.Type: ApplicationFiled: September 9, 2017Publication date: March 15, 2018Applicant: GENO LLCInventors: David H. Fine, Kurt A. Dasse
-
Publication number: 20170369316Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.Type: ApplicationFiled: July 10, 2017Publication date: December 28, 2017Applicant: GENO LLCInventors: David H. Fine, Gregory Vasquez, David P. Rounbehler
-
Publication number: 20170259025Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.Type: ApplicationFiled: March 24, 2017Publication date: September 14, 2017Applicant: GENO LLCInventors: David H. Fine, Bryan Johnson, Gregory Vasquez
-
Publication number: 20170197058Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: ApplicationFiled: December 20, 2016Publication date: July 13, 2017Applicant: GENO LLCInventors: David P. Rounbehler, David H. Fine
-
Patent number: 9701538Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.Type: GrantFiled: June 2, 2014Date of Patent: July 11, 2017Assignee: GENO LLCInventors: David H. Fine, Gregory Vasquez, David P. Rounbehler
-
Publication number: 20170182088Abstract: A method of providing a therapeutic composition includes administering a ROS reducing drug, calcium channel blocker, anti-fibrotic, anti-inflammatory, or anti-hypertensive drug and administering inhaled nitric oxide and reducing symptoms of oxidative stress and/or fibrosis in a patient.Type: ApplicationFiled: December 16, 2016Publication date: June 29, 2017Applicant: GENO LLCInventors: Kurt A. Dasse, Priscilla C. Petit, David H. Fine, Gregory Vasquez
-
Publication number: 20170182471Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.Type: ApplicationFiled: August 4, 2016Publication date: June 29, 2017Applicant: GENO LLCInventors: David H. Fine, David R. Rounbehler, Gregory Vasquez, Brian Johnson
-
Publication number: 20170165447Abstract: A method of modulating oxygen saturation levels can include measuring oxygen saturation levels in a patient, administering inhaled nitric oxide, adjusting the dose of oxygen in real time to a second dose based on the inhaled nitric oxide.Type: ApplicationFiled: December 11, 2016Publication date: June 15, 2017Applicant: GENO LLCInventors: Kurt A. Dasse, Priscilla C. Petit, David H. Fine, Mark K. Wedel
-
Publication number: 20170165293Abstract: A method of improving hemodynamics includes identifying a mammal having or at risk of developing a vascular depletion of nitric oxide due to nitric oxide scavenging by oxyhemoglobin, and introducing nitric oxide into the mammal's circulation.Type: ApplicationFiled: December 11, 2016Publication date: June 15, 2017Applicant: GENO LLCInventors: Kurt A. Dasse, Priscilla C. Petit, Mark K. Wedel, David H. Fine
-
Publication number: 20170165294Abstract: A method of modulating oxygen saturation levels can include measuring oxygen saturation levels in a patient, administering inhaled nitric oxide, adjusting the dose of oxygen in real time to a second dose based on the inhaled nitric oxide.Type: ApplicationFiled: December 11, 2016Publication date: June 15, 2017Applicant: GENO LLCInventors: Kurt A. Dasse, Priscilla C. Petit, David H. Fine, Mark K. Wedel
-
Patent number: 9604028Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.Type: GrantFiled: February 2, 2015Date of Patent: March 28, 2017Assignee: GENO LLCInventors: David H. Fine, Bryan Johnson, Gregory Vasquez
-
Patent number: 9522249Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.Type: GrantFiled: December 16, 2013Date of Patent: December 20, 2016Assignee: GENO LLCInventors: David P. Rounbehler, David H. Fine
-
Publication number: 20160346498Abstract: Various systems generating nitric oxide are disclosed herein. According to one embodiment, the system includes a first gas source providing nitrogen dioxide mixed in air or oxygen, and a second gas source supplying compressed air and/or compressed oxygen. The system also includes a ventilator coupled to the first and second gas sources, wherein the ventilator is resistant to nitrogen dioxide. The ventilator regulates gas flow and allows for the adjustment of nitrogen dioxide concentration in the gas flow. The system further includes one or more conversion devices operably coupled to the ventilator where the conversion devices convert nitrogen dioxide into nitric oxide. A patient interface delivers nitric oxide to the patient and is operably coupled to the conversion devices. The system allows oxygen and nitric oxide levels to be varied independently.Type: ApplicationFiled: May 25, 2016Publication date: December 1, 2016Applicant: GENO LLCInventors: Alfred Tector, Priscilla C. Petit, Kurt A. Dasse, David D. Fine
-
Patent number: 9408994Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.Type: GrantFiled: May 5, 2014Date of Patent: August 9, 2016Assignee: GENO LLCInventors: David H. Fine, David R. Rounbehler, Gregory Vasquez, Brian Johnson
-
Publication number: 20160151598Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.Type: ApplicationFiled: November 23, 2015Publication date: June 2, 2016Applicant: GENO LLCInventor: David H. Fine, I
-
Publication number: 20160106946Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4, activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.Type: ApplicationFiled: October 20, 2015Publication date: April 21, 2016Applicant: GENO LLCInventors: Barry N. Gellman, Eddie Tajudeen, Lucas Gamero, Joshua Hopkins, Ed Bromberg, Ryan Denton, Brian J. Johnson, David Fine
-
Publication number: 20150374949Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent.Type: ApplicationFiled: November 18, 2014Publication date: December 31, 2015Applicant: GENO LLCInventors: David H. Fine, Gregory Vasquez, Bryan Johnson, Ryan Denton, Lucas G. Gamero
-
Patent number: 9192718Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.Type: GrantFiled: December 21, 2013Date of Patent: November 24, 2015Assignee: GENO LLCInventor: David H. Fine