Abstract: The present invention is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.
Type:
Application
Filed:
October 5, 2021
Publication date:
February 17, 2022
Applicants:
DANA-FARBER CANCER INSTITUTE, INC., GENUS ONCOLOGY, LLC
Abstract: The present invention is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.
Type:
Grant
Filed:
July 6, 2018
Date of Patent:
October 5, 2021
Assignees:
DANA-FARBER CANCER INSTITUTE, INC., GENUS ONCOLOGY, LLC
Abstract: The present disclosure is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.
Type:
Grant
Filed:
July 31, 2017
Date of Patent:
April 14, 2020
Assignees:
DANA-FARBER CANCER INSTITUTE, INC., GENUS ONCOLOGY, LLC
Abstract: The present invention is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.
Type:
Grant
Filed:
January 29, 2015
Date of Patent:
August 28, 2018
Assignees:
DANA-FARBER CANCER INSTITUTE, INC., GENUS ONCOLOGY, LLC
Abstract: The present disclosure is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.
Type:
Application
Filed:
July 31, 2017
Publication date:
February 8, 2018
Applicants:
DANA-FARBER CANCER INSTITUTE, INC., GENUS ONCOLOGY, LLC
Abstract: The treatment of human epidermal growth factor receptor 2-positive (HER2+) cancers using a combination of anti-mucin 1 (anti-MUC1) therapy and anti-human epidermal growth factor receptor 2 (anti-HER2) therapy is described, such as the treatment of trastuzamab-resistant cancers, both primary and acquired, using the same combination of agents.
Type:
Grant
Filed:
March 10, 2014
Date of Patent:
October 17, 2017
Assignees:
Dana-Farber Cancer Institute, Inc., Genus Oncology, LLC
Abstract: The invention provides for treatment of MUC1+/ER?+/? cancers using an anti-MUC1 therapy, optionally including an anti-ER? therapy. In particular, the invention addresses the treatment of tamoxifen-resistant cancers, using MUC1+, and optionally anti-ER? therapy.
Type:
Grant
Filed:
March 10, 2014
Date of Patent:
February 21, 2017
Assignees:
DANA-FARBER CANCER INSTITUTE, INC., GENUS ONCOLOGY, LLC
Abstract: Peptides from the Mucin 1 (MUC1) cytoplasmic domain and methods of use therefor are described. These peptides can inhibit MUC1 oligomerization, thereby preventing tumor cell growth, inducing tumor cell apoptosis and necrosis of tumor tissue in vivo.
Type:
Grant
Filed:
February 12, 2015
Date of Patent:
January 17, 2017
Assignees:
Dana-Farber Cancer Institute, Inc., Genus Oncology, LLC
Abstract: The present invention is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.
Type:
Application
Filed:
January 29, 2015
Publication date:
November 24, 2016
Applicants:
DANA-FARBER CANCER INSTITUTE, INC., GENUS ONCOLOGY, LLC
Abstract: The invention provides for treatment of HER2+ cancers using a combination of anti-MUC1 therapy and anti-HER2 therapy. In particular, the invention addresses the treatment of trastuzamab-resistant cancers, both primary and acquired, using the same combination of agents.
Type:
Application
Filed:
March 10, 2014
Publication date:
March 17, 2016
Applicants:
GENUS ONCOLOGY, LLC, DANA-FARBER CANCER INSTITUTE, INC.
Abstract: The invention provides for treatment of MUC1+/ER?+/? cancers using an anti-MUC1 therapy, optionally including an anti-ER? therapy. In particular, the invention addresses the treatment of tamoxifen-resistant cancers, using MUC1+, and optionally anti-ER? therapy.
Type:
Application
Filed:
March 10, 2014
Publication date:
March 3, 2016
Applicants:
GENUS ONCOLOGY, LLC, DANA-FARBER CANCER INSTITUTE, INC.
Abstract: The invention provides for peptides from the MUC1 cytoplasmic domain and methods of use therefor. These peptides can inhibit MUC1 oligomerization, inhibit the interaction of MUC1 with NF-?B or a STAT, and block inflammatory response mediated by NF-?B or STAT signaling.
Type:
Grant
Filed:
December 23, 2013
Date of Patent:
August 4, 2015
Assignees:
Genus Oncology, LLC, Dana-Farber Cancer Institute, Inc.
Abstract: Peptides from the Mucin 1 (MUC1) cytoplasmic domain and methods of use therefor are described. These peptides can inhibit MUC1 oligomerization, thereby preventing tumor cell growth, inducing tumor cell apoptosis and necrosis of tumor tissue in vivo.
Type:
Application
Filed:
February 12, 2015
Publication date:
June 4, 2015
Applicants:
GENUS ONCOLOGY, LLC, DANA-FARBER CANCER INSTITUTE, INC.
Abstract: The invention provides method of treating cancers that express mucin 1 (MUC1) by the administration of phosphatidylinositol 3-kinase (PI3-K) inhibitors in combination with MUC1-directed cancer therapies. The PI3-K inhibition may advantageously be combined with peptides that inhibit MUC1 oligomerization, or further with other standard anticancer therapies such as chemo-, radio- and surgical therapies.
Type:
Grant
Filed:
March 28, 2013
Date of Patent:
June 2, 2015
Assignees:
Genus Oncology, LLC, Dana-Farber Cancer Institute, Inc.
Abstract: Peptides from the MUC1 cytoplasmic domain and methods of use therefor are described. These peptides can inhibit MUC1 oligomerization, thereby preventing tumor cell growth, inducing tumor cell apoptosis and necrosis of tumor tissue in vivo.
Type:
Grant
Filed:
February 24, 2012
Date of Patent:
February 17, 2015
Assignees:
Dana-Farber Cancer Institute, Inc., Genus Oncology, LLC
Abstract: The invention provides methods for the identification of small molecules that inhibit MUC1 oligomerization, and the functions flowing therefrom. In addition, small molecules that prevent MUC1 oligomerization are disclosed. Identified molecules will find use in treating a variety of MUC1-related inflammatory conditions, including MUC1-related cancers.
Type:
Grant
Filed:
March 10, 2011
Date of Patent:
February 10, 2015
Assignees:
Dana-Farber Cancer Institute, Inc., Genus Oncology, LLC
Abstract: The present invention is directed to improved compositions for cellular delivery of peptides. Using segments of only 3-5 positively-charged residues, one can effectively transfer peptides, including therapeutic peptides, into cells. Also provided are modified peptides such as those include stapled and cyclized peptide technology, as well as peptoids/peptidomimetics.
Type:
Application
Filed:
April 1, 2014
Publication date:
October 30, 2014
Applicants:
GENUS ONCOLOGY, LLC, DANA-FARBER CANCER INSTITUTE, INC.
Abstract: The invention provides for peptides from the MUC1 cytoplasmic domain and methods of use therefor. These peptides can inhibit MUC1 oligomerization, inhibit the interaction of MUC1 with NF-?B or a STAT, and block inflammatory response mediated by NF-?B or STAT signaling.
Type:
Application
Filed:
December 23, 2013
Publication date:
July 3, 2014
Applicants:
GENUS ONCOLOGY, LLC, DANA-FARBER CANCER INSTITUTE, INC.
Abstract: The present invention is directed to improved compositions for cellular delivery of peptides. Using segments of only 3-5 positively-charged residues, one can effectively transfer peptides, including therapeutic peptides, into cells. Also provided are modified peptides such as those include stapled and cyclized peptide technology, as well as peptoids/peptidomimetics.
Type:
Grant
Filed:
February 14, 2011
Date of Patent:
April 1, 2014
Assignees:
Dana-Farber Cancer Institute, Inc., Genus Oncology, LLC.
Abstract: The invention provides for peptides from the MUC1 cytoplasmic domain and methods of use therefor. These peptides can inhibit MUC1 oligomerization, inhibit the interaction of MUC1 with NF-?B or a STAT, and block inflammatory response mediated by NF-?B or STAT signaling.
Type:
Grant
Filed:
May 27, 2010
Date of Patent:
December 24, 2013
Assignees:
Dana-Farber Cancer Institute, Inc., Genus Oncology, LLC.