Patents Assigned to Georg-August-Universitat Gottingen Stiftung Offentlichen Rechts
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Publication number: 20240076620Abstract: The application describes methods for producing artificial skeletal muscle tissue from pluripotent stem cells. A method for producing skeletal myoblasts, skeletal myotubes and satellite cells from pluripotent stem cells is also disclosed. During the described methods, there is directed differentiation and maturation of the pluripotent stem cells into skeletal myotubes and satellite cells. The application also describes artificial skeletal muscle tissue which has multinuclear skeletal muscle fibres with satellite cells. Furthermore, the invention relates to mesodermally differentiated skeletal myoblast precursor cells, myogenically specified skeletal myoblast precursor cells, skeletal myoblast cells, satellite cells and skeletal myotubes, which can be produced by means of the disclosed methods. The application also describes the use of skeletal muscle tissue or the disclosed cells in drug testing or in medicine.Type: ApplicationFiled: October 13, 2020Publication date: March 7, 2024Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, UniversitätsmedizinInventors: Wolfram-Hubertus ZIMMERMANN, Malte TIBURCY, Mina SHAHRIYARI
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Publication number: 20230390460Abstract: A method for manufacturing a multilayer engineered heart muscle that includes (i) providing a liquid reconstitution mixture in a mould and (ii) culturing the mixture. The method includes a sequential addition of one or more further liquid reconstitution mixtures to obtain a multilayer engineered heart muscle. The muscle ideally has the form of a patch, a pouch, or a cylinder. Furthermore, a multilayer engineered heart muscle having collagen, cardiac myocytes and non-myocytes originating from at least 2 layers is disclosed. The multilayer engineered heart muscle forms the basis for several in vitro and in vivo applications such as the production of a multilayer engineered heart muscle for use in a patient, for example for use in heart repair.Type: ApplicationFiled: October 21, 2021Publication date: December 7, 2023Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, UniversitätsmedizinInventors: Wolfram-Hubertus ZIMMERMANN, Malte TIBURCY, Tim MEYER
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Publication number: 20230279357Abstract: The application describes a method for producing a population of cardiac stromal cells from pluripotent stem cells. Specifically, the method relates to (i) inducing epithelial-mesenchymal transition of pluripotent stem cell derived epicardial cells and (ii) amplifying the number of cardiac stromal cells in serum-free conditions. These cardiac stromal cells can be mass produced according to the described method and said cells maintain the expression of CD90, CD73 and CD44 in at least 80% of the cardiac stromal cells. Furthermore, the application relates to a population of cardiac stromal cells, which are pluripotent stem cells derived and wherein at least 80% of the cardiac stromal cells express CD90, CD73 and CD44. Said cardiac stromal form the basis for several in vitro and in vivo applications such as the production of engineered organ tissue and the support of, for example, heart repair. Also, a serum- free culture medium for the amplification of cardiac stromal cells is provided herein.Type: ApplicationFiled: July 28, 2021Publication date: September 7, 2023Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, UniversitätsmedizinInventors: Wolfram-Hubertus ZIMMERMANN, Malte TIBURCY
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Publication number: 20230256646Abstract: Production method for modified lignocellulose materials. The present invention relates to a production method for modified lignocellulose materials, comprising the impregnation of a lignocellulose material, especially wood, with a solution of an acid and an alcohol as well as treatment of the material with superheated steam at elevated temperatures.Type: ApplicationFiled: September 8, 2021Publication date: August 17, 2023Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen RechtsInventor: Holger Militz
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Publication number: 20230250143Abstract: The present invention relates to a mutant ion channel capable of being activated by light (‘light-activated’ ion channel) and having improved properties, nucleic acids and expression vectors encoding the mutant ion channel, cells comprising such nucleic acid or expression vector, devices containing the mutant ion channel, nucleic acid or expression vector as well as respective uses and methods.Type: ApplicationFiled: February 3, 2023Publication date: August 10, 2023Applicants: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin, OptoGenTech GmbHInventors: Tobias MOSER, Thomas MAGER, Maria ZERCHE
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Patent number: 11696897Abstract: A method for a treatment of individuals suffering from diseases associated with sulfatase deficiencies including lysosomal storage disease includes administering at least once a therapeutically effective amount of at least one retinoid. In particular, the compounds tazaroten and bexaroten have beneficial effects on these individuals. Pharmaceutical compositions comprising both active agents namely, tazaroten and bexaroten compounds, or similar compounds, provides for ready treatment of such individuals, and enhanced treatment is achieved with at least two active agents.Type: GrantFiled: October 2, 2019Date of Patent: July 11, 2023Assignee: GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS, UNIVERSITATSMEDIZINInventors: Lars Schlotawa, Matthias Kettwig, Karthikeyan Radhakrishnan, Thomas Dierks, Jutta Gartner, Matthias Baud
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Publication number: 20230203140Abstract: The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).Type: ApplicationFiled: October 2, 2019Publication date: June 29, 2023Applicants: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZIN, LIFEARCInventors: Thomas BAYER, Preeti BAKRANIA, Sarah DAVIES, Alex BROWN, Chido MPAMHANGA, David MATTHEWS, Mark CARR, Gareth HALL
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Publication number: 20230145938Abstract: The invention relates to an X-ray source (10) comprising at least one waveguide (30) for X-ray radiation, wherein the at least one waveguide (30) has a core (32) and a casing (40) surrounding the core (32), and wherein at least one part of the waveguide (30) is designed to emit X-ray radiation (50), if the part of the waveguide (30) is bombarded with electrons (52). The invention also relates to a system for generating X-ray radiation comprising an X-ray source of this type, and a method for generating X-ray radiation by means of an X-ray source of this type or a system of this type.Type: ApplicationFiled: April 7, 2021Publication date: May 11, 2023Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen RechtsInventors: Malte VASSHOLZ, Tim SALDITT
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Patent number: 11628065Abstract: The present invention relates to the diagnosis and treatment of joint-related diseases, in particular osteoarthritis. Based on the analysis of the microarchitecture, such as microchannels, of the subchondral bone, the present invention provides methods for evaluating the health state of a joint as well as determining whether a joint is prone to develop or has already developed a disease correlated to joint and cartilage destruction. The invention further provides for membranes and other implants mimicking healthy subchondral bone structure suitable for promoting regeneration of joint structure and function.Type: GrantFiled: March 24, 2020Date of Patent: April 18, 2023Assignee: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, UniversitätsmedizinInventors: Arndt F. Schilling, Shahed Taheri
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Patent number: 11622958Abstract: A first aspect of the invention relates to novel compounds and more precisely to novel bifunctional prodrugs and drugs. An additional aspect of the invention relates to antibody compound conjugates, wherein the compound is a claimed compound, and to pharmaceutical compositions containing the compound or antibody compound conjugate. The invention lastly relates to the use of this compound or antibody compound conjugates according to the invention in order to treat tumour diseases, particularly in mammals.Type: GrantFiled: October 28, 2016Date of Patent: April 11, 2023Assignee: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTSInventors: Lutz F. Tietze, Kamala Penchalaiah
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Publication number: 20220410440Abstract: The present invention relates to two-dimensional and three-dimensional shaped parts and composite materials made of popcorn and synthetic and/or natural binding agents which are cured in automatic moulding machines or similar pressing installations by means of radio wave technology or microwaves. By means of these technologies, light-weight, two-dimensional and three-dimensional shaped parts and composite materials can be produced for packaging, as interior and exterior parts (for example in automobile and mobile-home construction), shock absorbers, space-dividing elements, furniture, consumer goods, for the building trade of for heat insulation.Type: ApplicationFiled: February 24, 2021Publication date: December 29, 2022Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen RechtsInventors: Alireza Kharazipour, Markus Euring
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Publication number: 20220398702Abstract: A method of contrast enhancement of a three-dimensional light sheet microscopy image formed from N individual images each corresponding to a light sheet plane and spaced apart from each other in the z-direction by at least a distance d, the x/y-plane being the light sheet plane and the x-direction being the propagation direction of the light sheet of the light sheet plane, comprising: Deconvolution of the three-dimensional image in the z-direction, comprising: For each intensity vector of N intensities (Ix,y,1, . . . ,Ix,y,N) having the same x/y value, performing a multiplication with a tridiagonal N×N deconvolution matrix, which assigns to each voxel (x, y, n) a correction parameter f1, with which, by the multiplication of the deconvolution matrix with the intensity vector, for a component I(x, y, n) of the intensity vector the intensities Ix, y,n+1 and Ix, y,n?1 of the corresponding voxels of the neighboring image plane are multiplied, before they are subtracted from the intensity value I(x, y,n).Type: ApplicationFiled: October 14, 2020Publication date: December 15, 2022Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts UniversitätsmedizinInventors: Freddy Silvester WOUTERS-BUNT, Stephan HOCK
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Patent number: 11492594Abstract: The present invention provides a new method for producing Engineered Heart Muscle (EHM) under chemically fully defined conditions all compatible with GMP regulations. The resulting human myocardium generates force and shows typical heart muscle properties.Type: GrantFiled: March 10, 2020Date of Patent: November 8, 2022Assignee: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZINInventors: Wolfram-Hubertus Zimmermann, Malte Tiburcy, James Hudson
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Publication number: 20220295830Abstract: The invention relates to a method for producing dry pet food articles, dry pet food articles produced by the method, and the use of the resulting dry pet food articles. The dry pet food articles are produced by a method that includes the steps of providing a moulding material by contacting popcorn with a binder composition, the binder composition including a protein, a sugar alcohol, and water; and forming an article from the moulding material by administering heat and/or pressure to the moulding material in a mould. The dry pet food articles can be produced easily and provide very low caloric value per weight and particularly per volume, while also being well received by pets in terms of taste and texture.Type: ApplicationFiled: March 16, 2022Publication date: September 22, 2022Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen RechtsInventors: Markus Euring, Alireza Kharazipour
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Patent number: 11447462Abstract: The present invention describes a new alkynylation and cyanation agent, as well as its preparation and use to introduce nitrile (cyano) or alkyne groups into chemical target molecules by means of an electrophilic reaction. To enable an electrophilic reaction, the chemical backbone of dibenzothiophene was used.Type: GrantFiled: July 11, 2019Date of Patent: September 20, 2022Assignee: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTSInventors: Manuel Alcarazo Velasco, Christopher Golz, Bernd Waldecker, Xiangdong Li
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Publication number: 20220115609Abstract: The present invention relates to a nanoelectronic device, comprising a substrate layer (10), a first electrode layer (12) disposed on the substrate layer (10), a dielectric layer (16) disposed on the first electrode layer (12), a second electrode layer (18) disposed on the dielectric layer (16), wherein the dielectric layer (16) and the second electrode layer (18) are dimensioned such that at least one protruding portion (18a, 18b) of the second electrode layer (18) is formed in which the second electrode layer (18) extends beyond the dielectric layer such that opposing faces of the first and second electrode are formed (16), at least one semiconductor layer (20) disposed between the first electrode layer (12), one of the protruding portions (18a, 18b) of the second electrode layer (18) and the dielectric layer (16); and a gating arrangement (22) in contact with at least the semiconductor layer (20) as well as the first (12) and second (18) electrode layers.Type: ApplicationFiled: November 27, 2019Publication date: April 14, 2022Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen RechtsInventors: Jakob LENZ, Thomas WEITZ
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Publication number: 20220040933Abstract: The invention relates to shaped parts produced from popcorn which has previously been hydrophobised with a polymer. This allows very light and flexible shaped parts to be produced.Type: ApplicationFiled: December 10, 2019Publication date: February 10, 2022Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen RechtsInventors: Markus Euring, Alireza Kharazipour
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Publication number: 20210363541Abstract: The present disclosure concerns agents for use in a new therapeutic application for the prevention or treatment of cardiac arrhythmia and sudden cardiac death. More specifically, the present disclosure concerns an expression construct capable of enhancing expression of TBX5 in a subject to be treated, for use in the prevention or monotherapeutic treatment of a ventricular heart disease and associated complications selected from cardiac arrhythmia and sudden cardiac death.Type: ApplicationFiled: February 21, 2019Publication date: November 25, 2021Applicant: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZINInventors: Maria Patapia ZAFEIRIOU, Laura ZELARAYAN, Wolfram Hubertus ZIMMERMANN
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Publication number: 20210347867Abstract: The present invention relates to humanised antibodies that bind amyloid peptides, which antibodies comprise mutations in the heavy chain and/or light chain variable domains, which mutations improve the binding activity. The antibodies may be useful in the treatment of Alzheimer's disease (AD).Type: ApplicationFiled: October 2, 2019Publication date: November 11, 2021Applicants: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZIN, LIFEARCInventors: Thomas BAYER, Preeti BAKRANIA, Sarah DAVIES, Alex BROWN, Chido MPAMHANGA, David MATTHEWS, Mark CARR, Gareth HALL
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Publication number: 20210261519Abstract: The present invention describes a new alkynylation and cyanation agent, as well as its preparation and use to introduce nitrile (cyano) or alkyne groups into chemical target molecules by means of an electrophilic reaction. To enable an electrophilic reaction, the chemical backbone of dibenzothiophene was used.Type: ApplicationFiled: July 11, 2019Publication date: August 26, 2021Applicant: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTSInventors: Manuel ALCARAZO VELASCO, Christopher GOLZ, Bernd WALDECKER, Xiangdong LI