Patents Assigned to George Mason Research Foundation, Inc.
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Patent number: 10927155Abstract: In one aspect, the invention relates to compositions comprising peptides and/or peptidomimetic compounds, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, arthritis, obstructive lung disease, psoriasis, asthma, a defect in hematopoiesis, a neoplasia, a fungal infection, a parasitic infection, or an autoimmune disease, such as, but not limited to, rheumatoid arthritis, atopic allergy, anaphylaxis, psoriasis, asthma, lupus erythematosis, a myeloid cell disorder, or a eosinophil cell disorder. In an aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the ST2 and IL33 receptor/cytokine complexes. In a further aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the IL-1R1 and IL-1? receptor/cytokine complexes.Type: GrantFiled: November 18, 2016Date of Patent: February 23, 2021Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Lance Liotta, Alessandra Luchini, Virginia Espina, Mikell Paige
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Patent number: 10823738Abstract: Disclosed herein are methods for treating subjects with breast cancer, comprising determining a therapeutic regimen for cancer by measuring the level (amount) of proteins of one or more biomarkers. Also disclosed are methods of treating a subject with breast cancer by predicting or assessing a therapeutic outcome for subject.Type: GrantFiled: December 7, 2016Date of Patent: November 3, 2020Assignee: George Mason Research Foundation, Inc.Inventors: Emanuel Petricoin, Julia Wulfkuhle
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Publication number: 20200333220Abstract: Compositions and methods for the simulataneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: ApplicationFiled: May 20, 2020Publication date: October 22, 2020Applicant: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Lance LIOTTA, Virginia ESPINA, Nitin AGRAWAL, Alessandra Luchini KUNKEL
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Publication number: 20200267173Abstract: Processor(s) for detecting malicious software. A hardware virtual machine monitor (HVMM) operates under a host OS. Container(s) initialized with network application template(s) operate under a guest OS VM. A detection module operates under the guest OS VM includes a trigger detection module, a logging module and a container command module. The trigger detection module monitors activity on container(s) for a trigger event. The logging module writes activity report(s) in response to trigger event(s). The container command module issues command(s) in response to trigger event(s). The command(s) include a container start, stop and revert commands. A virtual machine control console operates under the host OS and starts/stops the HVMM. A container control module operates under the guest OSVM and controls container(s) in response to the command(s). The server communication module sends activity report(s) to a central collection network appliance that maintains a repository of activities for infected devices.Type: ApplicationFiled: February 13, 2020Publication date: August 20, 2020Applicant: George Mason Research Foundation, Inc.Inventors: Anup GHOSH, Yih HUANG, Jiang WANG, Angelos STAVROU
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Patent number: 10697866Abstract: Compositions and methods for the simulataneous capture and release using micropattern surfaces for tissue and cell microdissection. In one example, a patterned thermoplastic film has a first surface and a plurality of projections attached to and extending outwardly from the first surface. The projections form a pattern on the thermoplastic film.Type: GrantFiled: April 26, 2019Date of Patent: June 30, 2020Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Lance Liotta, Virginia Espina, Nitin Agrawal, Alessandra Luchini
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Patent number: 10690672Abstract: Disclosed herein are methods for treating subjects with breast cancer, comprising determining a therapeutic regimen for cancer by measuring the level (amount) of proteins of one or more biomarkers. Also disclosed are methods of predicting or assessing therapeutic outcome for subject.Type: GrantFiled: December 8, 2015Date of Patent: June 23, 2020Assignee: George Mason Research Foundation, Inc.Inventors: Emanuel Petricoin, Julia Wulfkuhle
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Publication number: 20200190156Abstract: Peptides and conjugates are described herein, including peptides having antimicrobial and/or anticancer properties, as are compositions, articles, and kits comprising such peptides and conjugates, and methods for using the peptides and conjugates.Type: ApplicationFiled: December 11, 2019Publication date: June 18, 2020Applicant: George Mason Research Foundation, Inc.Inventors: Barney Bishop, Saswata K. Sahoo, Justin Davis
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Patent number: 10633420Abstract: Peptides having antimicrobial properties are described herein, as are compositions containing such peptides, and methods for using the peptides.Type: GrantFiled: July 27, 2017Date of Patent: April 28, 2020Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.Inventors: Barney Bishop, Monique van Hoek, Ezra Myung Chul Chung
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Patent number: 10567414Abstract: Processor(s) for detecting malicious software. A hardware virtual machine monitor (HVMM) operates under a host OS. Container(s) initialized with network application template(s) operate under a guest OS VM. A detection module operates under the guest OS VM includes a trigger detection module, a logging module and a container command module. The trigger detection module monitors activity on container(s) for a trigger event. The logging module writes activity report(s) in response to trigger event(s). The container command module issues command(s) in response to trigger event(s). The command(s) include a container start, stop and revert commands. A virtual machine control console operates under the host OS and starts/stops the HVMM. A container control module operates under the guest OSVM and controls container(s) in response to the command(s). The server communication module sends activity report(s) to a central collection network appliance that maintains a repository of activities for infected devices.Type: GrantFiled: January 17, 2019Date of Patent: February 18, 2020Assignee: George Mason Research Foundation, Inc.Inventors: Anup Ghosh, Yih Huang, Jiang Wang, Angelos Stavrou
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Publication number: 20190352337Abstract: Peptides having antimicrobial properties are described herein, as are compositions containing such peptides, and methods for using the peptides.Type: ApplicationFiled: July 27, 2017Publication date: November 21, 2019Applicant: George Mason Research Foundation, Inc.Inventors: Barney Bishop, Monique van Hoek, Ezra Myung Chul Chung
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Publication number: 20190207961Abstract: A transparent proxy for malware detection includes a monitor module, a protocol determination module, a challenge generation module, a response determination module, and a data control module. The monitor module examines data originating from an application towards a remote server. The protocol determination module identifies the protocol type used for the data. The challenge generation module produces a challenge for the application based upon the protocol type, sends the challenge to the application, and maintains a state related to the data and the challenge. The response determination module makes a determination if an automatic non-interactive application response is received in response to the challenge from the application. The data control module allows the first data to continue to the remote server when the determination is valid. The data control module reports malware detection and blocks the data to continue to the remote server when the determination is invalid.Type: ApplicationFiled: March 7, 2019Publication date: July 4, 2019Applicant: George Mason Research Foundation, Inc.Inventors: Angelos STAVROU, Sushil JAJODIA, Anup K. GHOSH, Rhandi MARTIN, Charalampos ANDRIANAKIS
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Publication number: 20190158523Abstract: Processor(s) for detecting malicious software. A hardware virtual machine monitor (HVMM) operates under a host OS. Container(s) initialized with network application template(s) operate under a guest OS VM. A detection module operates under the guest OS VM includes a trigger detection module, a logging module and a container command module. The trigger detection module monitors activity on container(s) for a trigger event. The logging module writes activity report(s) in response to trigger event(s). The container command module issues command(s) in response to trigger event(s). The command(s) include a container start, stop and revert commands. A virtual machine control console operates under the host OS and starts/stops the HVMM. A container control module operates under the guest OSVM and controls container(s) in response to the command(s). The server communication module sends activity report(s) to a central collection network appliance that maintains a repository of activities for infected devices.Type: ApplicationFiled: January 17, 2019Publication date: May 23, 2019Applicant: George Mason Research Foundation, Inc.Inventors: Anup GHOSH, Yih HUANG, Jiang WANG, Angelos STAVROU
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Patent number: 10243975Abstract: A transparent proxy for malware detection includes a monitor module, a protocol determination module, a challenge generation module, a response determination module, and a data control module. The monitor module examines data originating from an application towards a remote server. The protocol determination module identifies the protocol type used for the data. The challenge generation module produces a challenge for the application based upon the protocol type, sends the challenge to the application, and maintains a state related to the data and the challenge. The response determination module makes a determination if an automatic non-interactive application response is received in response to the challenge from the application. The data control module allows the first data to continue to the remote server when the determination is valid. The data control module reports malware detection and blocks the data to continue to the remote server when the determination is invalid.Type: GrantFiled: November 22, 2016Date of Patent: March 26, 2019Assignee: George Mason Research Foundation, Inc.Inventors: Angelos Stavrou, Sushil Jajodia, Anup K. Ghosh, Rhandi Martin, Charalampos Andrianakis
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Publication number: 20190033319Abstract: The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.Type: ApplicationFiled: September 25, 2018Publication date: January 31, 2019Applicant: George Mason Research Foundation, Inc.Inventors: Alessandra Luchini, Lance Liotta, Virginia Espina
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Patent number: 10187417Abstract: Processor(s) for detecting malicious software. A hardware virtual machine monitor (HVMM) operates under a host OS. Container(s) initialized with network application template(s) operate under a guest OS VM. A detection module operates under the guest OS VM includes a trigger detection module, a logging module and a container command module. The trigger detection module monitors activity on container(s) for a trigger event. The logging module writes activity report(s) in response to trigger event(s). The container command module issues command(s) in response to trigger event(s). The command(s) include a container start, stop and revert commands. A virtual machine control console operates under the host OS and starts/stops the HVMM. A container control module operates under the guest OSVM and controls container(s) in response to the command(s). The server communication module sends activity report(s) to a central collection network appliance that maintains a repository of activities for infected devices.Type: GrantFiled: December 14, 2017Date of Patent: January 22, 2019Assignee: George Mason Research Foundation, Inc.Inventors: Anup Ghosh, Yih Huang, Jiang Wang, Angelos Stavrou
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Patent number: 10174081Abstract: Materials and methods for making and using cationic anti-microbial peptides (CAMPs), and compositions containing such peptides.Type: GrantFiled: April 20, 2012Date of Patent: January 8, 2019Assignee: George Mason Research Foundation, Inc.Inventors: Barney Bishop, Monique van Hoek
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Patent number: 10126304Abstract: The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.Type: GrantFiled: January 15, 2014Date of Patent: November 13, 2018Assignee: George Mason Research Foundation, Inc.Inventors: Alessandra Luchini, Lance Liotta, Virginia Espina
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Patent number: 10120998Abstract: An embodiment for providing a secure virtual browsing environment includes creating a virtual browsing environment with a virtualized operating system sharing an operating system kernel of a supporting operating system and executing the browser application within the virtual browsing environment. Another embodiment includes receiving a website selection within a browser application, determining if the website selection corresponds to a secure bookmark, and creating a second virtual browsing environment and executing the browser application within the second virtual browsing environment to access the website selection when the website selection corresponds to a website specified as a secure bookmark.Type: GrantFiled: August 29, 2016Date of Patent: November 6, 2018Assignee: George Mason Research Foundation, Inc.Inventors: Anup K. Ghosh, Sushil Jajodia, Yih Huang, Jiang Wang
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Publication number: 20180103053Abstract: Processor(s) for detecting malicious software. A hardware virtual machine monitor (HVMM) operates under a host OS. Container(s) initialized with network application template(s) operate under a guest OSVM. A detection module operates under the guest OSVM includes a trigger detection module, a logging module and a container command module. The trigger detection module monitors activity on container(s) for a trigger event. The logging module writes activity report(s) in response to trigger event(s). The container command module issues command(s) in response to trigger event(s). The command(s) include a container start, stop and revert commands. A virtual machine control console operates under the host OS and starts/stops the HVMM. A container control module operates under the guest OSVM and controls container(s) in response to the command(s). The server communication module sends activity report(s) to a central collection network appliance that maintains a repository of activities for infected devices.Type: ApplicationFiled: December 14, 2017Publication date: April 12, 2018Applicant: George Mason Research Foundation, Inc.Inventors: Anup GHOSH, Yih HUANG, Jiang WANG, Angelos STAVROU
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Publication number: 20180046479Abstract: An on-demand disposable virtual work system that includes: a virtual machine monitor to host virtual machines, a virtual machine pool manager, a host operating system, a host program permissions list, and a request handler module. The virtual machine pool manager manages virtual machine resources. The host operating system interfaces with a user and virtual machines created with an image of a reference operating system. The host program permissions list may be a black list and/or a white list used to indicate allowable programs. The request handler module allows execution of the program if the program is allowable. If the program is not allowable, the host request handler module: denies program execution and urges a virtual machine specified by the virtual machine pool manager to execute the program. The virtual machine is terminated when the program closes.Type: ApplicationFiled: October 27, 2017Publication date: February 15, 2018Applicant: George Mason Research Foundation, Inc.Inventors: Anup K. GHOSH, Sushil JAJODIA, Yih HUANG, Jiang WANG