Abstract: The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate with the over-expression of total c-erbB2 as measured by IHC or FISH, for selection and inclusion for c-erbB2-direct treatment and therapy. Furthermore, the present invention provides a reliable method to determine whether a subject with a cancer of epithelial origin who has been determined to be c-erbB2 positive by IHC and by FISH should be excluded from c-erbB2-direct treatment because of a non-significant level of phosphorylated c-erbB2 in epithelial tumor tissue.

Abstract: A hardware-assisted integrity monitor may include one or more target machines and/or monitor machines. A target machine may include one or more processors, which may include one or more system management modes (SMM). A SMM may include one or more register checking modules, which may be configured to determine one or more current CPU register states. A SMM may include one or more acquiring modules, which may be configured to determine one or more current memory states. A SMM may include one or more network modules, which may be configured to direct one or more communications, for example of one or more current CPU register states and/or current memory states, to a monitor machine. A monitor machine may include one or more network modules and/or analysis modules. An analysis module may be configured to determine memory state differences and/or determine CPU register states differences.

Abstract: This invention relates, e.g., to a composition that, at room temperature, when contacted with a sample comprising phosphoproteins, can fix and stabilize cellular phosphoproteins, preserve cellular morphology, and allow the sample to be frozen to generate a cryostat frozen section suitable for molecular analysis. The composition comprises (1) a fixative that stabilizes the proteins in the sample and that has a sufficient water content for a stabilizer and/or a permeability enhancing agent to be soluble therein; (2) a stabilizer, comprising (a) a kinase inhibitor and (b) a phosphatase inhibitor and, optionally, (c) a protease (e.g., proteinase) inhibitor; (3) a permeability enhancing agent; and (4) lactic acid. Methods and kits are described for preserving phosphoproteins, using such a composition. Also described are endogenous surrogate markers for monitoring protein degradation, including the loss of posttranslational modifications (such as phosphorylation), e.g.

Abstract: An immunoassay device incorporating porous polymeric capture nanoparticles within either the sample collection vessel or pre-impregnated into a porous substratum within fluid flow path of the analytical device is presented. This incorporation of capture particles within the immunoassay device improves sensitivity while removing the requirement for pre-processing of samples prior to loading the immunoassay device. A preferred embodiment is coreshell bait containing capture nanoparticles which perform three functions in one step, in solution: a) molecular size sieving, b) target analyte sequestration and concentration, and c) protection from degradation. The polymeric matrix of the capture particles may be made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle.

Abstract: A transparent proxy for malware detection includes a monitor module, a protocol determination module, a challenge generation module, a response determination module, and a data control module. The monitor module examines data originating from an application towards a remote server. The protocol determination module identifies the protocol type used for the data. The challenge generation module produces a challenge for the application based upon the protocol type, sends the challenge to the application, and maintains a state related to the data and the challenge. The response determination module makes a determination if an automatic non-interactive application response is received in response to the challenge from the application. The data control module allows the first data to continue to the remote server when the determination is valid. The data control module reports malware detection and blocks the data to continue to the remote server when the determination is invalid.

Abstract: An on-demand disposable virtual work system that includes: a virtual machine monitor to host virtual machines, a virtual machine pool manager, a host operating system, a host program permissions list, and a request handler module. The virtual machine pool manager manages virtual machine resources. The host operating system interfaces with a user and virtual machines created with an image of a reference operating system. The host program permissions list may be a black list and/or a white list used to indicate allowable programs. The request handler module allows execution of the program if the program is allowable. If the program is not allowable, the host request handler module: denies program execution and urges a virtual machine specified by the virtual machine pool manager to execute the program. The virtual machine is terminated when the program closes.

Abstract: An embodiment for providing a secure virtual browsing environment includes creating a virtual browsing environment with a virtualized operating system sharing an operating system kernel of a supporting operating system and executing the browser application within the virtual browsing environment. Another embodiment includes receiving a website selection within a browser application, determining if the website selection corresponds to a secure bookmark, and creating a second virtual browsing environment and executing the browser application within the second virtual browsing environment to access the website selection when the website selection corresponds to a website specified as a secure bookmark.

Abstract: Methods are provided for treating cancer metastasis by administering a therapeutic composition targeting a kinase substrate cascade.

Abstract: A hardware-assisted integrity monitor may include one or more target machines and/or monitor machines. A target machine may include one or more processors, which may include one or more system management modes (SMM). A SMM may include one or more register checking modules, which may be configured to determine one or more current CPU register states. A SMM may include one or more acquiring modules, which may be configured to determine one or more current memory states. A SMM may include one or more network modules, which may be configured to direct one or more communications, for example of one or more current CPU register states and/or current memory states, to a monitor machine. A monitor machine may include one or more network modules and/or analysis modules. An analysis module may be configured to determine memory state differences and/or determine CPU register states differences.

Abstract: An attack resistant continuous network service trustworthiness controller comprising: state estimation module(s), response selection module(s), actuation module(s), and client dispatcher communication module(s) for maintaining the availability and integrity of online server(s). The state estimation module(s) are configured to generate state estimate(s) for online server(s) using behavior data obtained using sensor module(s). The response selection module(s) are configured to determine corrective action(s) to maintain the availability and integrity of online server(s) when state estimate(s) indicate that the integrity of an online server(s) is compromised. The actuation module(s) are configured to activate actuator(s) based upon the corrective action(s). Client dispatcher communication module(s) are configured to communicate online server availability information to a client dispatcher.

Abstract: An attack resistant continuous network service trustworthiness controller comprising: state estimation module(s), response selection module(s), actuation module(s), and client dispatcher communication module(s) for maintaining the availability and integrity of online server(s). The state estimation module(s) are configured to generate state estimate(s) for online server(s) using behavior data obtained using sensor module(s). The response selection module(s) are configured to determine corrective action(s) to maintain the availability and integrity of online server(s) when state estimate(s) indicate that the integrity of an online server(s) is compromised. The actuation module(s) are configured to activate actuator(s) based upon the corrective action(s). Client dispatcher communication module(s) are configured to communicate online server availability information to a client dispatcher.

Abstract: A router, implemented in hardware and/or hardware in combination with software for routing packets, so as to limit congestion. The router monitors incoming data flows as well as the queue length of its buffer to control the rate of incoming data flows via a flow controller. The flow controller uses at least one of: a Smith predictor, a proportional-integral controller, a proportional-derivative controller, and a proportional controller.

Abstract: A method, system and computer program product for controlling a processing unit connected to a network. The method includes providing information to the network by the processing unit via plural communication channels; sending a reset signal from a controller to a reset unit of the processing unit after a specified amount of time, the reset unit being connected only to a communication channel of the controller and being isolated from the plural communication channels; and rebooting the processor unit when the reset signal is received by the reset unit.

Abstract: An iron composition having a plurality of elemental components is disclosed. The major component is an iron component of at least about 68% to about 92% iron by weight. Other components by weight include manganese; cerium; carbon; phosphorous; sulfur; aluminum; silicon; chromium; copper; and zinc. Combined with layers of sand, brick chips and/or charcoal, the iron composition can be used to create a water filter for filtering inorganic arsenic species and soluble metal ions out of water. To enhance hydrous ferric oxide complexation and precipitation, the iron composition may be treated with food grade acids or a water mixture.