Abstract: Devices and systems are disclosed which reduce compressional forces and allows for the induction of mild CCI injuries. An exemplary device features a resettable fall-away platform which allows for ultra-mild injuries to be induced on mice that are under light anesthesia. The result is injuries which do not produce long periods of unconsciousness, do not cause compressive injury and cause no increase in time-to-righting over control mice.

Abstract: A method and apparatus for intrusion detection includes generating graph data from a sequence of messages in a communication network. The graph data denotes a node for each message identifier in the sequence of messages and an edge for each pair of consecutive message identifiers. Pair counts are generated for edges in the graph data as a number of times the associated pair of consecutive message identifiers occurs in the sequence. Input feature vectors are generated for nodes in the graph data. The vectors include data content of messages associated with the node and a pair count for each edge connected to the node. The input feature vectors are processed through a first graph neural network, based on the graph data, and then through one or more layers of a classifier to classify the sequence of messages as containing an anomaly or not.

Abstract: An embodiment of the invention provides a method of generating, ex vivo production of soluble Lox-1 (sLox-1), comprising: introducing a sample containing a blood free from an anti-coagulant factor into a device; adding a coagulation enhancing material in the sample; incubating the device; forming a cultured blood clot in the device; and shedding of the sLox-1 outside the cultured blood clot, wherein the method is configured to shed sLox-1 more than an anti-coagulated blood.

Abstract: Methods and system for improved aircraft safety are described herein. A machine learning model may be trained using historical flight data for a number of previously flown flights where an automation function autonomously disengaged. The trained machine learning model may be used to generate probabilistic alert rules. The probabilistic alert rules may be used by a computing device onboard an aircraft to provide contextual information to flight crew relating to engagement status for one or more automation functions of the aircraft.

Abstract: A method of authenticating a user that includes initializing the multi-factor authentication system based on an input; presenting a challenge requesting the user to enter a specific authenticator of a sequence of authenticators stored in the multi-factor authentication system, where the stored sequence of authenticators represents a combination of a plurality of authentication factors; receiving an authenticator from the user in response to the challenge; verifying identity of the user by determining whether the received authenticator matches the specific authenticator requested by the challenge; and granting the access based on a determination that the received authenticator matches the specific authenticator requested, or denying the access based on a determination that the received authenticator does not match the specific authenticator requested.

Abstract: Devices for generating electrical energy along with methods of fabrication and methods of use are disclosed. An example device can comprise one or more layers of a transition metal dichalcogenide material. An example device can comprise a mechano-electric generator. Another example device can comprise a thermoelectric generator.

Abstract: Tacrolimus is an immunosuppressant drug. The present disclosure provides an anti-fibrotic agent by transforming Tacrolimus, such that the anti-fibrotic agent is used for treating fibrosis. The anti-fibrotic agent is not immunosuppressant. In one embodiment, the present invention provides a method to transform Tacrolimus into an anti-fibrotic agent.

Abstract: Disclosed are methods and systems for system call reduction. An application container may be used to encapsulate an application and to determine an operation state of the application. Based on the application state, the application container may determine one or more allowable system calls for the application. The application container may restrict access to one or more system calls excluded from the one or more allowable system calls.

Abstract: Provided is a modified J-aggregate (MJ). In some embodiments, the MJ is nanoscale, sub-micronscale, or microscale. Also provided is an MJ conjugate. Also provided are processes for making an MJ or an MJ conjugate. Photoacoustic imaging methods employing the MJ or MJ conjugate are also provided.

Abstract: Provided is an engineered antimicrobial peptide. Also provided is a composition comprising an engineered antimicrobial peptide. Provided is a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of a composition comprising an engineered antimicrobial peptide. Also provided is a method of producing an engineered antimicrobial peptide.

Abstract: The present disclosure describes methods for determining the functional consequences of mutations. The methods include the use of machine learning to identify and quantify features of all atom molecular dynamics simulations to obtain the disruptive severity of genetic variants on molecular function.

Abstract: Methods and systems for recovery-adaptive biobehavioral-regulation treatments for relapse. In various embodiments, a user wears a sensor that collects biobehavioral data regarding the user and is operatively connected to an electronic computing device associated with the user. Generally, the disclosed system monitors the collected biobehavioral data to mitigate relapse of a previous disease and/or disorder (e.g., addiction, depression, post-traumatic stress disorder, etc.) by presenting personalized recovery cues (e.g., images, videos, etc.) to the user when the user is experiencing stimuli that increase the risk of relapse. In addition, the user has the ability to modulate the implicated brain structure image interactively on the smartphone interface (e.g., changing the size, texture, color, image), in order to change its functionality in real-time and improve in-the-moment emotional regulation.

Abstract: The present invention provides modified alphaviruses and compositions, methods, and kits for preparing and using them to elicit an immune response to an alphavirus in a subject.

Abstract: An embodiment relates to a method, comprising: obtaining a biological sample, performing a protein complex immunoprecipitation (Co-IP) on the sample, performing a reverse phase protein array (RPPA) on the sample after performing the protein complex immunoprecipitation, and identifying one or more protein complexes. A further embodiment relates to a method of treatment, comprising: obtaining a tissue sample from a patient, performing Co-IP then RPPA on the sample, identifying a protein complex, determining whether the protein complex comprises known protein drug targets, and treating the patient with a drug that interacts with the known protein drug targets.

Abstract: A system for autonomous control in power systems is disclosed. In particular, a secure overlay communication model (“SOCOM”) is disclosed, the system including a combination of hardware and software for detecting power grid states, and determining appropriate actions for addressing detected states. The SOCOM is a logic-based system deployed onto computing devices such as field programmable gate arrays installed at bus controllers, Supervisory Control and Data Acquisition Systems (“SCADAs”), Intelligent Electronic Devices (“IEDs”), or other computing devices in power grid stations and substations. The logic-based nature of the SOCOM allows for seamless integration with preexisting power system equipment. In response to detecting various power grid faults such as line failures and over-current states, the system automatically rearranges power line configurations at the power stations and/or substations.

Abstract: Embodiments relate to methods comprising expressing or overexpressing P-selectin glycoprotein ligand-1 (PSGL-1) in human immunodeficiency virus (HIV) producing cells; isolating HIV particles from the HIV producing cells; and preparing the isolated HIV particles as a HIV vaccine. Embodiments relate to systems comprising a HIV vaccine comprising live attenuated, inactivated, or non-infectious HIV particles. Embodiments relate to systems capable of performing a method comprising administering a vaccine comprising live attenuated, inactivated, or non-infectious HIV particles to a subject in need of the vaccine; and treating or preventing one or more disease states in the subject resulting from HIV infection.

Abstract: The present disclosure provides a method of restoring immune reconstitution, immune control of viremia, and one or more T cell functions in a subject infected with HIV. The method includes administering to the subject infected with HIV an agent that targets the cofilin pathway.

Abstract: The present disclosure provides compositions and methods for modulating PERK activity and/or expression in cells for use in treatment or prevention of viral infection, including by reducing translation of viral non-structural proteins in cells using compositions and/or compounds that inhibit PERK activity and/or expression.

Abstract: A dynamically deployable, low visibility pneumatic cofferdam for flood mitigation is disclosed. The cofferdam includes a first planar component, a second planar component, an inflatable hermetic airbag sandwiched therebetween, and connection members attached to the first planar component, a second planar component to form a cofferdam unit. The connection members are adjustable to apply and maintain a desired amount of pressure on the airbag to enable a watertight seal to be formed. The cofferdam units may be sized and designed to sealingly mate adjacent cofferdam units in a variety of configurations to form watertight seals. The cofferdam units may also be sized and designed to attach to seawalls, flood walls, sidewalks, or other infrastructure. When in a deployed state, the height of the cofferdam may be adjusted to a desired height to provide flood mitigation. When in an undeployed state, the cofferdam remains in a substantially flat and unobtrusive position.

Abstract: A wearable device measures, tracks, and monitors a wearer's physical physiological conditions during a rehabilitation period. Metrics such as temperature, patellar shifting, limb circumference, and acceleration may be collected. Changes in monitored conditions may be assessed for detecting medical abnormalities which require specialized attention, including for example embolisms or infections. A networked communication system and various user interfaces may be used for medical support personnel and patients alike to stay updated with the patient's rehabilitation progress and to make adjustments in a patient's individual rehabilitation program.