Abstract: A system and method for determining at least one hardening strategy to prevent at least one attack, comprising: performing processing associated with obtaining at least one attack graph, the at least one attack graph comprising at least one goal condition, at least one initial condition, and at least one exploit; performing processing associated with obtaining at least one allowable action that disables the at least one initial condition; performing processing associated with obtaining costs associated with the at least one allowable action; and performing processing associated with utilizing the at least one allowable action to determine at least one recommended strategy from the at least one allowable action taking into account the costs.

Abstract: A computerized system and method for identifying one or more cryptographic operations from software code, comprising: performing processing associated with identifying, one or more cryptographic operations in the software code, the software code being run on a processor; and performing processing associated with identifying a boundary for each cryptographic operation in the software code.

Abstract: Described herein are progenitor cancer cells and cell lines isolated from human breast ductal carcinoma in situ (DCIS) lesions and the uses of these cells or cell lines in drug design, drug screening, and monitoring in vivo therapy. The DCIS malignant precursor cells or cell lines are epithelial in origin, are positive for markers of autophagy, show at least one genetic difference from normal cells of said fragment, form 3-D tube-like structures or ball aggregates, or are inhibited in formation of 3-D structures and migration by treatment with chloroquine. In one embodiment, there is a loss of heterozygosity (LOH) that is narrowly confined to a region of chromosome 6p (6p21.1-6p12.3) that contains the SUPT3H gene.

Abstract: Systems and methods for determining a probability of changing from one state to another in a stochastic entity, comprising: determining the compact component matrix utilizing characteristic information of the stochastic entity; determining the compact composite component matrix by taking a Kroneker product of the compact component matrix and an identity matrix; determining and placing all current states for the stochastic entity into a state space matrix; determining a Q matrix and/or a transition rate matrix using the compact composite component matrix and basic conditions or variables of the problem domain and/or a compact transition rate matrix; and performing Markov chain Monte Carlo (MCMC) simulation using information from the state space matrix and information from the transition rate matrix to determine the probability of changing from one state to another state in the stochastic entity.

Abstract: A systems biology approach is used to characterize and relate the intestinal (gut) microbiome of a host organism (e.g. a human) to physiological processes within the host. Information regarding the types and relative amounts of gut microflora is correlated with physiological processes indicative of e.g., a patient's risk of developing a disease or condition, likelihood of responding to a particular treatment, for adjusting treatment protocols, etc. The information is also used to identify novel suitable therapeutic targets and/or to develop and monitor the outcome of therapeutic treatments. An exemplary disease/condition is the development of hepatic encephalopathy (HE), particularly in patients with liver cirrhosis.

Abstract: This invention provides a method of producing cyathin A3 in a culture of Cyathus helenae. It employs added bacteria to stimulate production of cyathin A3.

Abstract: A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrinan in a manner that permits access to brain sites and/or the macula of the patient.

Abstract: The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.

Abstract: The compound is a clay aqueous suspension made of at least one 2:1 layer phyllosilicate clay mineral, at least one 1:1 layer phyllosilicate clay mineral, and water that can be used to sequester asbestos, such as chrysotile, as well as dust and other fibrous particles, at all scales of contamination.

Abstract: A watermarking system embeds a watermark into data values that may be streamed. A data hash is calculated using data values and a hash key. The data values are grouped. The groups include a first group and a second group. A first group hash is calculated using data values in the first group and a first group hash key. A second group hash is calculated using data values in the second group and a second group hash key. A watermark is constructed based on the first group hash and the second group hash. The value of at least one of the data values in the first group is modified using the watermark.

Abstract: A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrin in a manner that permits access to brain sites and/or the macula of the patient.

Abstract: Provided are methods of identifying a metabolic target in a cancer stem cell that include using a microarray to identify intracellular signaling networks within a population of cancer stem cells that respond to a growth factor for the stem cell. Also provided are methods of determining a personalized therapeutic regime that include receiving metabolic information relating to a cancer stem cell in a patient, determining the patient's personal criteria relevant to the therapeutic regime, and combining the metabolic and personal criteria. Also provided are a diagnostic test for establishing a personalized therapeutic regime for a colon cancer patient and methods of reducing colon cancer stem cells/treating colon cancer.

Abstract: The present invention relates to methods and compositions for diagnosing, monitoring, prognosticating, analyzing, etc., polymicrobial diseases. The present invention also relates to the microbial community present in the digestive tract and lumen in normal subjects, and subjects with digestive tract diseases, especially diseases of the colon, such as inflammatory bowel disease, including ulcerative colitis, Crohn's syndrome, and pouchitis. The present invention especially relates to compositions and methods for diagnosing and prognosticating the mentioned diseases and conditions, e.g., to determine the presence of the disease in a subject, to determine a therapeutic regimen, to determine a therapeutic regimen, to determine the onset of active disease, to determine the predisposition to the disease, etc.

Abstract: A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrin in a manner that permits access to brain sites and/or the macula of the patient.

Abstract: The present invention relates to methods and systems for creating secure cookies. The methods can be used to create, receive, and transmit secure cookies, confidential cookies, and authentication cookies.

Abstract: The present invention relates to methods and apparatus for measuring a relative utility for each of a plurality of goals which comprise a system objective. More particularly, the present invention relates to methods, systems, and apparatus for quantifying the relative contribution of specific goals to a set of broader goals, and for enabling decision making, and resource allocation, with regard to the performance of those goals based on the quantified relative contribution. In preferred embodiments, a lattice is created based on an ordering relation and relative values are apportioned to the goals using their position in the lattice as including, included, and/or unrelated goals.

Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.

Abstract: The present invention concerns the compounds of the formula: and the prodrug and salts thereof, wherein R may be a hydroxyl or other pendent group and Ar is an aryl. The compositions may be adapted for the treatment of neurodegenerative diseases. Further, the compositions may be adapted as a pharmaceutical such as an antipsychotic pharmaceutical, an antibiotic pharmaceutical, an antiviral pharmaceutical or an antitumor pharmaceutical.

Abstract: A method for detecting fungi in a liquid matrix which also contains bacteria comprising adding an effective amount of at least one compound which inhibits a pathway by which bacteria synthesize lysine to inhibit bacterial growth and allowing for growth of the fungi for subsequent detection. Compounds for this method include nicotinic acid, or analogues of dihydropicolinic acid, and analogues of diaminopimelic acid.

Abstract: A method and system for determining the similarity between an image and at least one training sample is disclosed. This invention is a novel Gabor Feature Classifier (GFC), a principal application of which may be for face recognition. The GFC applies the Enhanced FLD Model (EFM) to an augmented Gabor feature vector derived from the Gabor wavelet transformation of images.