Patents Assigned to Georgetown University
  • Publication number: 20230306960
    Abstract: A method for training vibrotactile speech perception in the absence of auditory speech can comprise selecting a first word, generating a first control signal configured to cause at least one vibrotactile transducer to vibrate against a person's body with a first vibration pattern based on the first word, sampling a second word, generating a second control signal configured to cause a vibrotactile transducer to vibrate against the person's body with a second vibration pattern based on the second word, and presenting a comparison between the first word and the second word to the person. An apparatus for training vibrotactile speech perception can comprise array of vibrotactile transducers can be in contact with the person's body. The array of vibrotactile transducers can replicate a vibration pattern based on one or more spoken words.
    Type: Application
    Filed: June 1, 2023
    Publication date: September 28, 2023
    Applicant: Georgetown University
    Inventors: Patrick S. Malone, Maximilian Riesenhuber
  • Publication number: 20230233520
    Abstract: Methods of treating human papillomavirus (HPV)-induced conditions, HPV-induced lesions, or HPV-infected cells. The method involves administering one or more artemisinin-related compounds and one or more histone deacetylase (HDAC) inhibitors. In addition, treatment regimens involving the use of artemisinin-related compounds and HDAC inhibitors, and kits comprising pharmaceutical compositions of artemisinin-related compounds and HDAC inhibitors.
    Type: Application
    Filed: April 23, 2021
    Publication date: July 27, 2023
    Applicant: Georgetown University
    Inventors: Richard Schlegel, Hang Yuan
  • Publication number: 20230210849
    Abstract: Provided herein are compositions and methods for the treatment and prevention of cadherin-11 (CDH11) related diseases. The compositions include CDH11 inhibitors that are formulated for use in combination with chemotherapy and/or immunotherapy, to treat or prevent cancer, fibrosis, and autoimmune diseases.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 6, 2023
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Sivanesan DAKSHANAMURTHY, Ivana PERAN, Stephen W. BYERS, Shahin ASSEFNIA
  • Publication number: 20230201187
    Abstract: Methods of inhibiting release of one or more cytokines, or inhibiting a cytokine storm, or preventing cytokine release syndrome or a cytokines storm, in a subject infected with severe acquired respiratory syndrome coronavirus 2. The method involves administering to the subject an effective amount of one or more NAD+ precursors, one or more inhibitors of stimulator of interferon genes (STING), one or more famesoid X receptor (FXR) agonists, or a combination thereof. In addition, treatment regimens involving the use of one or more NAD+ precursors, one or more STING inhibitors, one or more FXR agonists, or a combination thereof; and kits comprising pharmaceutical compositions of one or more NAD+ precursors, one or more inhibitors of stimulator of interferon genes, one or more farnesoid X receptor agonists, or combinations thereof.
    Type: Application
    Filed: May 22, 2021
    Publication date: June 29, 2023
    Applicant: Georgetown University
    Inventor: Moshe Levi
  • Publication number: 20230201223
    Abstract: Compositions comprising bile acids or their salts and methods of use thereof for the treatment of residual lesions of vascular anomalies.
    Type: Application
    Filed: December 16, 2022
    Publication date: June 29, 2023
    Applicants: Georgetown University, MedStar Health
    Inventors: Cynthia Marie Carver DEKLOTZ, Michael Andrew CARDIS
  • Patent number: 11688386
    Abstract: A method for training vibrotactile speech perception in the absence of auditory speech includes selecting a first word, generating a first control signal configured to cause at least one vibrotactile transducer to vibrate against a person's body with a first vibration pattern based on the first word, sampling a second word spoken by the person, generating a second control signal configured to cause at least one vibrotactile transducer to vibrate against the person's body with a second vibration pattern based on the sampled second word, and presenting a comparison between the first word and the second word to the person. An array of vibrotactile transducers can be in contact with the person's body.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: June 27, 2023
    Assignee: Georgetown University
    Inventors: Patrick S. Malone, Maximilian Riesenhuber
  • Patent number: 11681965
    Abstract: A specialized computing environment that includes hardware and data security features to enable competitive organizations to co-analyze proprietary data without revealing the underlying proprietary data to unauthorized users. Proprietary data are stored in volatile memory, which may be automatically erased according to pre-stored criteria. The analysis is performed automatically by a processing unit without human intervention. Analytical results are sanitized (e.g., using data masking) to prevent the analytical result from being tracible to any particular data source. Sanitized analytical results are output without outputting the underlying proprietary data (except to users authorized to validate analytical results). The computing environment is enclosed within a secure enclosure (e.g.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: June 20, 2023
    Assignees: Georgetown University, Children's Hospital Medical Center
    Inventors: David Hartley, Ophir Frieder
  • Patent number: 11672789
    Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: June 13, 2023
    Assignees: Georgetown University, The Board of Regents of the University of Oklahoma
    Inventors: Milton L. Brown, Yali Kong, Courtney Houchen, Sripathi M. Sureban, Parthasarathy Chandrakesan
  • Publication number: 20230167414
    Abstract: Methods of generating a population of tumor cells, such as circulating tumor cells (CTCs) isolated from fluid from a subject. The methods involve collecting a fluid sample containing the tumor cells from the subject, and culturing the tumor cells in the fluid sample in a three-dimensional cell culture, wherein the three-dimensional cell culture comprises at least one inhibitor of Rho-kinase to generate the population of CTCs. If the fluid is whole blood or contains blood, the method may also involve subjecting the fluid sample to density gradient separation to separate the tumor cells from the fluid prior to culturing. In addition, methods of identifying a candidate treatment for a subject having a condition marked by the presence of tumor cells, methods of monitoring in a subject the persistence, regression, or progression of a disease or condition marked by the presence of tumor cells, and methods of generating a cell line of tumor cells.
    Type: Application
    Filed: April 26, 2021
    Publication date: June 1, 2023
    Applicant: Georgetown University
    Inventors: Paula R. Pohlmann, Seema Agarwal, Richard Schlegel
  • Patent number: 11635436
    Abstract: The present invention relates to compositions and methods for determining the absolute configuration of D/L-cysteine and/or the enantiomeric composition of cysteine and/or the concentration of total cysteine in a sample. Uses of the composition and method are also described.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: April 25, 2023
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Christian Wolf, Fathima Yushra Thanzeel
  • Publication number: 20230095341
    Abstract: Provided herein are compositions and methods for treating or preventing a neurodegenerative disease, a neurodevelop-mental disease, a myodegenerative disease, a prion disease, a lysosomal storage disease or cancer in a subject.
    Type: Application
    Filed: January 29, 2021
    Publication date: March 30, 2023
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Charbel MOUSSA, Christian WOLF, Balaraman KALUVU
  • Patent number: 11605371
    Abstract: Embodiments of the present systems and methods may provide techniques for synthesizing speech in any voice in any language in any accent. For example, in an embodiment, a text-to-speech conversion system may comprise a text converter adapted to convert input text to at least one phoneme selected from a plurality of phonemes stored in memory, a machine-learning model storing voice patterns for a plurality of individuals and adapted to receive the at least one phoneme and an identity of a speaker and to generate acoustic features for each phoneme, and a decoder adapted to receive the generated acoustic features and to generate a speech signal simulating a voice of the identified speaker in a language.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 14, 2023
    Assignee: Georgetown University
    Inventors: Joe Garman, Ophir Frieder
  • Patent number: 11596623
    Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site-utilizing virus (IRES-utilizing virus) involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: March 7, 2023
    Assignees: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Hemayet Ullah, Sivanesan Dakshanamurthy
  • Patent number: 11589781
    Abstract: A gait analysis system, which includes a neural network with a recurrent neural network layer and a fully connected layer, that receives sensor data indicative of an individual's gait and outputs an assessment regarding the individual's health. The neural network is trained using training data indicative of abnormal gaits and normal gaits. To analyze the training data and the sensor data, the recurrent neural network layer parses each piece of data into a series of windows and analyzes each window in series to generate a context vector characterizing each window and the previously analyzed windows. The fully connected layer, having been trained to differentiate between normal gaits and abnormal gaits based on context vectors characterizing the training data, is used to generate a final assessment characterizing the user gate as normal or abnormal using one or more of the context vectors characterizing the sensor data.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: February 28, 2023
    Assignee: Georgetown University
    Inventors: Gholam Motamedi, Ophir Frieder, Cristopher Flagg, Jian-Young Wu
  • Patent number: 11576901
    Abstract: A method effective in treating a viral infection involves administering a therapeutically effective amount of at least one compound capable of inhibiting expression of at least a portion of a virus genome containing an internal ribosomal entry site, or a pharmaceutically acceptable salt thereof. The compound has an azole moiety comprising a five member heterocyclic ring containing at least one nitrogen atom, a hydrophobic moiety bonded to the heterocyclic ring of the azole, and a donor/acceptor moiety bonded to the heterocyclic ring having at least one of hydrogen bond donor and a hydrogen bond acceptor.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: February 14, 2023
    Assignees: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Hemayet Ullah, Sivanesan Dakshanamurthy
  • Publication number: 20230024038
    Abstract: A method that includes introducing at least one analyte into a gas plasma; generating neutral species from atoms of the analyte in the gas plasma; preferentially transporting the neutral species downstream of the gas plasma relative to any ions produced in the gas plasma; and reacting the neutral species of the analyte with at least one reagent ion downstream of the plasma resulting in ion species of the analyte, wherein the at least one reagent ion is supplied by an independent ion source.
    Type: Application
    Filed: February 25, 2021
    Publication date: January 26, 2023
    Applicant: Georgetown University
    Inventors: Kaveh Jorabchi, Joseph Lesniewski, Kunyu Zheng, Samuel White
  • Patent number: 11554126
    Abstract: Compositions comprising bile acids or their salts and methods of use thereof for the treatment of residual lesions of vascular anomalies.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: January 17, 2023
    Assignees: Georgetown University, MedStar Health
    Inventors: Cynthia Marie Carver Deklotz, Michael Andrew Cardis
  • Patent number: 11534090
    Abstract: A microfluidic device for non-invasively and passively accessing interstitial fluid from a patient includes a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: December 27, 2022
    Assignee: Georgetown University
    Inventor: Makarand Paranjape
  • Patent number: 11529324
    Abstract: Provided are methods of treating pulmonary artery hypertension with a Kv11.1 (ERG or hERG1) channel inhibitor. In certain embodiments, the Kv11.1 channel inhibitor is dofetilide. In certain embodiments, a subject to be treated using a method of the disclosure is not in need of treatment for an irregular heart rhythm, e.g., atrial fibrillation.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: December 20, 2022
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Tinatin I. Brelidze, Yuichiro J. Suzuki, Nataliia Shults, Vladyslava Rybka
  • Publication number: 20220380284
    Abstract: A composition comprising a compound of formula I: wherein n is 5, and R is methyl; and the composition is in an essentially guest-free solid form.
    Type: Application
    Filed: May 27, 2022
    Publication date: December 1, 2022
    Applicant: Georgetown University
    Inventors: K. Travis Holman, Prashant K. Pandey