Patents Assigned to Georgetown University
  • Publication number: 20200154682
    Abstract: Monitoring systems and methods for tracking movement of one or more animals in an enclosure, such as a fish tank, include introducing various stimuli, such as food, light, and auditory stimuli, and tracking the movement of the animals in response to these stimuli. Movement patterns of the animals can be determined and analyzed from data obtain from cameras that record images/videos of the relevant portions of the enclosure.
    Type: Application
    Filed: January 22, 2020
    Publication date: May 21, 2020
    Applicant: Georgetown University
    Inventors: Jagmeet S. Kanwal, Bishen J. Singh
  • Patent number: 10658678
    Abstract: Provided are electrocatalysts, fuel cells, methods of making fuel cells, and methods of generating an electric current, each featuring a platinum (Pt)-containing substrate in contact with an aqueous solution comprising Pb2+. Electrocatalysts of the invention are formed via underpotential deposition (UPD) when a trace amount of Pb2+ is present in the electrolyte of a half anodic cell for oxidizing formic acid using Pt as the anode. Surprisingly, the UPD process dramatically enhances the activity of formic acid oxidation, at least as much as 10-fold compared with palladium (Pd) black. In an embodiment, the electrocatalyst comprises a Pt-containing substrate, a submonolayer of lead (Pb) adsorbed onto the Pt-containing substrate, and an aqueous solution comprising Pb2+, wherein the concentration of Pb2+ in the aqueous solution is 10 to 500 ?m.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: May 19, 2020
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: YuYe J. Tong, Dejun Chen
  • Patent number: 10610494
    Abstract: Provided are methods and devices useful for treating a respiratory disease or disorder involving the central or upper airways. The methods and devices deliver to central or upper airways of a subject a vapor or aerosol comprising an effective amount of an active ingredient selected from the group consisting of menthol, menthone, neomenthol, isomenthol, and menthofuran. The methods are useful for treating conditions including cough, asthma, bronchitis, and allergic rhinitis.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: April 7, 2020
    Assignee: GEORGETOWN UNIVERSITY
    Inventor: Adriane Fugh-Berman
  • Patent number: 10600503
    Abstract: The present invention is directed to a platform (e.g., Web-based) that enables basic and clinical research activities by integrating patient characteristics and clinical outcome data with a variety of high-throughput research data in a unified environment. While several rich data repositories for high dimensional research data exist in the public domain, most focus on a single data type and do not support integration across multiple technologies. The present invention in at least one embodiment includes a broad collection of bioinformatics and systems biology tools for analysis and visualization of four major “omics” types: DNA, mRNA, microRNA, and metabolites, as well as next-generation sequencing. The present invention helps facilitate systems medicine by providing easy identification of trends and patterns in integrated datasets and hence facilitate the use of better targeted therapies for cancer.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: March 24, 2020
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Subha Madhavan, Michael A. Harris, Yuriy Gusev, Andrew Shinohara, David M. Tanenbaum, Kevin Rosso
  • Patent number: 10592310
    Abstract: A system and method involves detecting operational social disruptive events on a global scale, modeling data in conjunction with linguistics analysis to establish responsive actions, and generating visualization and executing models for communicating information.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: March 17, 2020
    Assignee: Georgetown University
    Inventors: Peter Chao-yuan Li, Jeffrey R. Collmann, Jane W. Blake, Mark G. Polyak, James M. Wilson, Jae In Yoon, Manabu Torii, Carla S. Thomas
  • Publication number: 20200084206
    Abstract: Embodiments of the present systems and methods may provide techniques for two-factor authentication (2FA) that leverage voice assistant devices such as Google Home and Amazon Echo. For example, in an embodiment, a computer-implemented method of authentication may comprise receiving an authentication request for a user of a service, authenticating the user using two-factor authentication, wherein at least one factor of the two-factor authentication is audio, and validating the authentication request upon validation of both factors of the two-factor authentication.
    Type: Application
    Filed: September 9, 2019
    Publication date: March 12, 2020
    Applicant: Georgetown University
    Inventors: Tavish Vaidya, Micah Sherr
  • Publication number: 20200071338
    Abstract: Cavitand compositions that comprise void spaces are disclosed. The void spaces may be empty, which means that voids are free of guest molecules or atoms, or the void spaces may comprise guest molecules or atoms that are normally in their gas phase at standard temperature and pressure. These cavitands may be useful for industrial applications, such as the separation or storage of gasses. Novel cavitand compounds are also disclosed.
    Type: Application
    Filed: September 10, 2019
    Publication date: March 5, 2020
    Applicant: Georgetown University
    Inventors: Kevin Travis Holman, Christopher Kane
  • Patent number: 10578629
    Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile. A decrease in the value of the subject's lipidomic profile over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: March 3, 2020
    Assignees: GEORGETOWN UNIVERSITY, UNIVERSITY OF ROCHESTER
    Inventors: Howard J. Federoff, Mark E. Mapstone, Amrita K. Cheema, Massimo S. Fiandaca
  • Publication number: 20200064065
    Abstract: A system for producing dry nanoparticles from a liquid includes a closed tubing system which incorporates a mister, heater and an electrostatic collector therein. The system is able to produce dry nanoparticles from liquid-suspensions and from solvent solutions.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 27, 2020
    Applicant: Georgetown University
    Inventors: Edward Van Keuren, Grace Maglieri, Roman Kosarzycki, Leon Der
  • Patent number: 10568305
    Abstract: Monitoring systems and methods for tracking movement of one or more animals in an enclosure, such as a fish tank, include introducing various stimuli, such as food, light, and auditory stimuli, and tracking the movement of the animals in response to these stimuli. Movement patterns of the animals can be determined and analyzed from data obtain from cameras that record images/videos of the relevant portions of the enclosure.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: February 25, 2020
    Assignee: Georgetown University
    Inventors: Jagmeet S. Kanwal, Bishen J. Singh
  • Publication number: 20200030796
    Abstract: A system for determining the presence of cell-free non-coding RNA (cfNCR) biomarkers in interstitial fluid includes a microfluidic device for non-invasively and passively accessing interstitial fluid from a patient. The microfluidic device is formed of a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.
    Type: Application
    Filed: January 31, 2018
    Publication date: January 30, 2020
    Applicant: Georgetown University
    Inventor: Makarand Paranjape
  • Patent number: 10534052
    Abstract: Provided herein are methods related to identifying an early, asymptomatic (prodromal) stage of a neurodegenerative disease or identifying a subject with a symptomatic neurodegenerative disease, including, for example, mild cognitive impairment (MCI), Alzheimer's Disease (AD), or HIV-associated neurocognitive disorder (HAND), using functional MRI data from the subject. Methods are also provided for treating a subject identified with the methods taught herein and for modifying or selecting treatment based on the results of fMRI. Methods are also available for staging neurodegenerative disease and for identifying agents useful in treating them.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 14, 2020
    Assignee: Georgetown University
    Inventors: Xiong Jiang, Maximilian Riesenhuber
  • Patent number: 10532095
    Abstract: The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: January 14, 2020
    Assignees: Catherex, Inc., Georgetown University, The General Hospital Corporation
    Inventors: Paul Johnson, Robert L. Martuza, Samuel D. Rabkin, Tomoki Todo
  • Publication number: 20200011881
    Abstract: The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.
    Type: Application
    Filed: February 2, 2018
    Publication date: January 9, 2020
    Applicants: Georgetown University, University of Rochester
    Inventors: Mark E. Mapstone, Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema
  • Publication number: 20200000804
    Abstract: Provided herein are methods of treating a lysosomal storage disorder (LSD) in a subject and methods of promoting lysosomal clearance in one or more cells of a subject.
    Type: Application
    Filed: February 9, 2018
    Publication date: January 2, 2020
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: Charbel Moussa
  • Patent number: 10521727
    Abstract: A method for generating hypotheses in a corpus of data comprises selecting a form of ontology; coding the corpus of data based on the form of the ontology; generating ontology space based on coding results and the ontology; transforming the ontology space into a hypothesis space by grouping hypotheses; weighing hypotheses included in the hypothesis space; and applying a science-based sorting algorithm configured to model a science-based treatment of the weighted hypotheses.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: December 31, 2019
    Assignee: Georgetown University
    Inventors: Ophir Frieder, David Hartley
  • Patent number: 10503347
    Abstract: A system and method involves detecting operational social disruptive events on a global scale, assigning disease or non-disease event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actions, generating visualization and modeling capabilities for communicating information, and modeling disease or non-disease propagation for containment and forecasting purposes.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 10, 2019
    Assignee: Georgetown University
    Inventors: Ahmed A. Humayun, Steven J. Silverstein, Gregory P. Zalasky, Kevin D. Jones
  • Patent number: 10503792
    Abstract: Embodiments may provide a cache for query results that can adapt the cache-space utilization to the popularity of the various topics represented in the query stream. For example, a method for query processing may perform receiving a plurality of queries for data, determining at least one topic associated with each query, and requesting data responsive to each query from a data cache comprising a plurality of partitions, including at least a static cache partition, a dynamic cache partition, and a temporal cache partition, the temporal cache partition may store data based on a topic associated with the data, and may be further partitioned into a plurality of topic portions, each portion may store data relating to an associated topic, wherein the associated topic may be selected from among determined topics of queries received by the computer system, and the data cache may retrieve data for the queries from the computer system.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: December 10, 2019
    Assignee: Georgetown University
    Inventors: Ophir Frieder, Ida Mele, Raffaele Perego, Nicola Tonellotto
  • Patent number: 10487056
    Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: November 26, 2019
    Assignee: Georgetown University
    Inventors: Milton L. Brown, Shujie Hou, Partha Banerjee, Karishma Amin
  • Patent number: 10482037
    Abstract: A system and method for deterring malicious network attacks. The system and method is configured to execute instructions on at least one of the processors to generate a plurality of random blocks of data; generate a first XOR result by using the XOR function with the plurality of random blocks of data as the XOR function inputs; generate a tail value by using the XOR function with the first XOR result and a random encryption key as the XOR function inputs; encrypt a designated file using the random encryption key; write the plurality of random blocks and tail value to at least one storage medium; and write the encrypted designated file to at least one storage medium.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: November 19, 2019
    Assignee: Georgetown University
    Inventor: Thomas Clay Shields