Patents Assigned to Georgetown University
  • Publication number: 20210134418
    Abstract: Embodiments of the present systems and methods may provide techniques to predict the success or failure of a drug used for disease treatment. For example, a method of determining drug efficacy may include, for a plurality of patients, generating a directed acyclic graph from health related information of each patient comprising nodes representing a medical event of the patient, at least one first edge connecting the first node to an additional node, each additional edge connecting nodes representing two consecutive medical events, the edge having a weight based on a time difference between the two consecutive medical events, capturing a plurality of features from each directed acyclic graph, generating a binary graph classification model on captured features of each directed acyclic graph, determining a probability that a drug or treatment will be effective using the binary graph classification model, and determining a drug to be prescribed to a patient based on the determined probability.
    Type: Application
    Filed: November 3, 2020
    Publication date: May 6, 2021
    Applicant: Georgetown University
    Inventors: Ophir FRIEDER, Hao-Ren YAO, Der-Chen CHANG
  • Patent number: 10984130
    Abstract: Technologies are provided for efficiently querying a database using a plurality of oblivious random-access memories (ORAMs) while providing differential privacy. Subsets of a set of database records can be stored in a plurality of ORAMs. The subsets of database records in the separate ORAMs can be concurrently accessed (for example, by a database query server). When a database query is received, a number of database records that match the query can be identified for each of the ORAMs. A differential privacy constraint can be used to determine an additional number of database records to be retrieved from each ORAM. The differential privacy constraint can specify an upper bound on the number of records to be retrieved from each ORAM to prevent (or reduce the risk of) information leakage. Once all of the identified records are retrieved from the plurality of ORAMs, the additional records can be discarded.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: April 20, 2021
    Assignees: Georgetown University, Trustees of Boston University, Bornio, Inc.
    Inventors: Yaacov Nissim Kobliner, Georgios Kellaris, George Kollios
  • Patent number: 10948441
    Abstract: A system for carrying out electrochemical nuclear magnetic resonance spectroscopy (EC-NMR) is disclosed, along with methods of manufacturing the EC-NMR system, and methods of using the EC-NMR system to monitor electrochemical reactions. The system comprises interdigitated electrodes arranged in a cylindrically symmetric manner. The system allows for nuclear magnetic resonance spectroscopy to be carried out on a sample during electrolysis with minimal effect to its sensitivity.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 16, 2021
    Assignee: Georgetown University
    Inventors: YuYe J. Tong, Eric G. Sorte
  • Publication number: 20210074263
    Abstract: A method for training vibrotactile speech perception in the absence of auditory speech can comprise selecting a first word, generating a first control signal configured to cause at least one vibrotactile transducer to vibrate against a person's body with a first vibration pattern based on the first word, sampling a second word spoken by the person, generating a second control signal configured to cause at least one vibrotactile transducer to vibrate against the person's body with a second vibration pattern based on the sampled second word, and presenting a comparison between the first word and the second word to the person. An array of vibrotactile transducers can be in contact with the person's body.
    Type: Application
    Filed: August 31, 2018
    Publication date: March 11, 2021
    Applicant: Georgetown University
    Inventors: Patrick S. MALONE, Maximilian RIESENHUBER
  • Publication number: 20210048431
    Abstract: The present invention relates to assays, methods, and kits to assess traumatic brain injury (TBI) in a subject. The present invention also relates to ultrasensitive assays for GFAP, tau, CKBB, IL-1?, IL-2, IL-6, IL-10, IL-22, IP-10, TNF?, TSLP, NFL, and/or NFH.
    Type: Application
    Filed: March 8, 2019
    Publication date: February 18, 2021
    Applicants: MESO SCALE TECHNOLOGIES, LLC., GEORGETOWN UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jeff DEBAD, Joshua GATSON, Mark BURNS, Arianna BIESSO
  • Publication number: 20210038565
    Abstract: In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication of a virus, by administering artemisinin-related compounds.
    Type: Application
    Filed: October 16, 2020
    Publication date: February 11, 2021
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Richard Schlegel, Dan-Paul Hartmann, Astrid Baege
  • Patent number: 10916331
    Abstract: Described herein are methods of predicting drug-target interactions and methods of using the information for drug repurposing. The methods described herein combine different descriptors, including, for example, atom pair similarity, shape, topology and chemical signatures, physico-chemical functional descriptors, contact points of the ligand and the target protein, chemical similarity, and docking score.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 9, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Sivanesan Dakshanamurthy, Stephen W. Byers
  • Patent number: 10902955
    Abstract: A triage system that determines whether a user is likely to have contracted a disease based on sensor data received from a user device (e.g., a smartphone or activity tracker). Each symptom is identified by comparing sensor data to a predetermined baseline and comparing the difference to a predetermined symptom threshold. Because direct measurement of symptoms using the sensors available to the user may not be feasible or sufficiently accurate, the triage system also uses surrogates the identify certain symptoms. For example, a fever may be identified using heart data, a cough or shortness of breath may be identified by analyzing recorded sound, fatigue may be identified by analyzing the movement of the user device, and loss of smell or taste may be identified by recording sound and using speech detection algorithms to identify phrases in the recorded sound indicative of loss of smell or taste.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: January 26, 2021
    Assignee: Georgetown University
    Inventors: Howard Federoff, Ophir Frieder
  • Patent number: 10900980
    Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: January 26, 2021
    Assignees: Georgetown University, University of Rochester
    Inventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
  • Patent number: 10900977
    Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's proteomic profile and comparing the value of the subject's proteomic profile with the value of a normal proteomic profile. A change in the value of the subject's proteomic profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: January 26, 2021
    Assignees: Georgetown University, University of Rochester
    Inventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone, Xiaogang Zhong
  • Patent number: 10900941
    Abstract: The present invention is directed to analytical methods for determining the concentration, and/or stereoisomeric excess, and/or absolute configuration of chiral analytes in a sample.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: January 26, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Christian Wolf, Keith Bentley, Burcin Irfanoglu, Peng Zhang
  • Patent number: 10890589
    Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: January 12, 2021
    Assignees: Georgetown University, University of Rochester
    Inventors: Massimo S. Fiandaca, Mark E. Mapstone, Howard J. Federoff, Xiaogang Zhong, Amrita K. Cheema
  • Patent number: 10889860
    Abstract: Provided are methods, kits, and systems useful in the performance of analysis and reporting of highly polymorphic loci, including, in particular, the performance of analysis and reporting of HLA typing. Combining one-step sequencing and sequence-specific oligonucleotide probe hybridization, the methods, kits, and systems offer improved efficiency of HLA typing while providing detailed sequencing information. In certain embodiments the methods and systems comprise one or more software applications to facilitate data acquisition, processing, and reporting.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: January 12, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Jennifer Ng, Carolyn K. Hurley, Bin Tu, Carly Masaberg
  • Patent number: 10892526
    Abstract: Provided are batteries and fuel cells incorporating a stripline detector for use in nuclear magnetic resonance (NMR). The stripline batteries and fuel cells can be used for in situ NMR measurement of battery or fuel cell chemistry. Also provided are methods for measuring in situ battery and fuel cell NMR using the stripline batteries and fuel cells of the invention.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: January 12, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: YuYe J. Tong, Eric G. Sorte
  • Publication number: 20200405717
    Abstract: Provided herein are methods of treating or preventing a neurodegenerative disease, a myodegenerative disease or a prion disease in a subject comprising administering a tyrosine kinase inhibitor.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 31, 2020
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: Charbel Moussa
  • Publication number: 20200387521
    Abstract: A system and method for connecting one or more client applications with one or more knowledge representation servers and communicating there between includes an application programming interface (API) and a hypergraph transfer protocol (HGTP), for facilitating communication between the one or more client applications and one or more knowledge representation servers responsive to a client application request. The client application request includes an API call for a specific entity that is received by a first knowledge representation server. If the first knowledge representation server does not manage the specific entity, the first knowledge representation server forwards the specific entity call to a second knowledge representation server via the HGTP using a universal unique identifier (UUID) associated with the specific entity having encoded therein a network address for the second knowledge representation server.
    Type: Application
    Filed: June 30, 2020
    Publication date: December 10, 2020
    Applicant: Georgetown University
    Inventor: J. Cory Smart
  • Publication number: 20200383996
    Abstract: Provided herein are methods for treating a cholecystokinin (CCK) receptor-expressing cancerous tumor in a subject. Also provided are methods for increasing sensitivity of a (CCK) receptor-expressing cancerous tumor in a subject to immunotherapy.
    Type: Application
    Filed: March 15, 2018
    Publication date: December 10, 2020
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Jill P. Smith, Louis Weiner, Sandra Jablonski, Sandeep Nadella, Shangzi Wang
  • Publication number: 20200384000
    Abstract: Compositions comprising bile acids or their salts and methods of use thereof for the treatment of residual lesions of vascular anomalies.
    Type: Application
    Filed: December 17, 2018
    Publication date: December 10, 2020
    Applicants: Georgetown University, MedStar Health
    Inventors: Cynthia Marie Carver DEKLOTZ, Michael Andrew CARDIS
  • Publication number: 20200371115
    Abstract: Provided herein are methods for detecting a cerebrospinal fluid-specific (CSF-specific) glycoform of Apolipoprotein E (APOE) in a subject.
    Type: Application
    Filed: August 15, 2018
    Publication date: November 26, 2020
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: George William Rebeck, Sarah Flowers
  • Publication number: 20200363436
    Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty acids (PUFAs) into the brain from plasma in a test subject and comparing this measured influx to a normal standard influx. An increase in influx of PUFAs from the plasma into the brain is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
    Type: Application
    Filed: June 1, 2020
    Publication date: November 19, 2020
    Applicant: Georgetown University
    Inventors: Massimo S. Fiandaca, Howard J. Federoff