Patents Assigned to Georgetown University
  • Compositions and methods for inducing cell death
    Publication number: 20040024025
    Abstract: A method is provided for inducing cell death comprising administering to said cell a composition comprising tempo or a functional derivative of tempo.
    Type: Application
    Filed: March 13, 2003
    Publication date: February 5, 2004
    Applicant: Georgetown University
    Inventors: Usha Kasid, Simeng Suy
  • Immunoreactive peptides from Epstein-Barr virus
    Publication number: 20040013665
    Abstract: Epstein-Barr virus (EBV) specific polypeptides are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment of EBV-associated disease.
    Type: Application
    Filed: May 21, 2003
    Publication date: January 22, 2004
    Applicants: Ortho Diagnostic Systems, Inc., Georgetown University
    Inventors: Richard S. Smith, Gary R. Pearson, D. Elliot Parks, Susan Pothen Varghese
  • Structure based discovery of inhibitors of matriptase for the treatment of cancer and other conditions
    Patent number: 6677377
    Abstract: The present invention relates to a method of inhibiting carcinoma progression wherein matriptase plays a role in a subject in need of such inhibition including administering to a subject an effective amount of a compound comprising two positively charged groups, which are the same or different. The groups are linked by a chemical group having a length of between 5 and 30 A, and preferably between 15 and 24 A. Diagnostic methods based on matriptase action and therapeutic methods involving inhibition of matriptase activity are provided.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: January 13, 2004
    Assignee: Georgetown University School of Medicine
    Inventors: Chen-Yong Lin, Robert B. Dickson, Shaomeng Wang, Istvan Enyedy, Sheau-Ling Lee
  • Gene shinc-3 and diagnostic and therapeutic uses thereof
    Publication number: 20040005603
    Abstract: The invention provides a SHINC-3 polynucleotide, which can be a nucleic acid encoding all or a portion of a SHINC-3 protein, or a complementary polynucleotide or antisense polynucleotide. In another aspect, the invention provides a SHINC-3 polypeptide, which can be a full-length SHINC-3 protein or a fragment thereof or an analog or homolog thereof. Desirably, the SHINC-3 polypeptide modulates apoptosis. In another aspect, the invention provides an antibody that specifically binds a SHINC-3 polypeptide.
    Type: Application
    Filed: April 10, 2003
    Publication date: January 8, 2004
    Applicants: Georgetown University, NeoPharm, Inc.
    Inventors: Usha Kasid, Isamu Sakabe, Imran Ahmad
  • Method of treating hepatitis delta virus infection
    Patent number: 6670342
    Abstract: A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the hepatitis B surface or preS1 antigen in the host 100-fold or more relative to pretreatment values in vivo; or to not more than 1 microgram per milliliter in vivo. In a preferred embodiment, the nucleoside is L-FMAU, or a pharmaceutically acceptable salt or prodrug thereof.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: December 30, 2003
    Assignees: Georgetown University, Cornell Research Foundation, Inc., University of Georgia Research Foundation, Inc.
    Inventors: John L. Casey, Brent E. Korba, Paul J. Cote, John L. Gerin, Bud C. Tennant, Chung K. Chu
  • Inhibitors of phosphatidyl myo-inositol cycle
    Patent number: 6667340
    Abstract: The present invention relates to the preparation and biological activity of 3-deoxy-Dmyo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as anti-tumor 5 agents which effectively inhibit the growth of mammalian cells.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: December 23, 2003
    Assignees: Arizona Board of Regents on behalf of the University of Arizona, Georgetown University School of Medicine
    Inventors: Alan P. Kozikowski, Lixin Qiao, Garth Powis
  • Radiosurgery methods that utilize stereotactic methods to precisely deliver high dosages of radiation especially to the spine
    Patent number: 6665555
    Abstract: A system for delivery of high dosage of radiation to a targeted spinal area is provided. This is accomplished by a system which provides for precise immobilization and positioning of the treated spinal area during dose planning and treatment via stereotactic radiosurgery. Advantages of the system include convenience to the patient, enhanced efficacy, and reduced risk of radiotoxicity to non-target tissues.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: December 16, 2003
    Assignee: Georgetown University School of Medicine
    Inventors: Fraser C. Henderson, James Rodgers, Azam Niroomand-Rad, Kevin Cleary, Anatoly Dritschilo, Leon Der
  • Cationic liposomal delivery system and therapeutic use thereof
    Publication number: 20030229040
    Abstract: The invention relates to novel cationic lipid formulations and use thereof for treatment of cancer, especially in combination with radiation.
    Type: Application
    Filed: January 21, 2003
    Publication date: December 11, 2003
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Usha Kasid, Prafulla Gokhale, Chuanbo Zhang, Anatoly Dritschilo, Aquilur Rahman
  • Gene SHINC-2 and diagnostic and therapeutic uses thereof
    Publication number: 20030225023
    Abstract: The invention provides a SHINC-2 polynucleotide, which can be a nucleic acid encoding all or a portion of a SHINC-2 protein, or a complementary polynucleotide or antisense polynucleotide. In another aspect, the invention provides a SHINC-2 polypeptide, which can be a full-length SHINC-2 protein or a fragment thereof or an analog or homolog thereof Desirably, the SHINC-2 polypeptide modulates apoptosis. In another aspect, the invention provides an antibody that specifically binds a SHINC-2 polypeptide.
    Type: Application
    Filed: April 10, 2003
    Publication date: December 4, 2003
    Applicants: Georgetown University, NeoPharm, Inc.
    Inventors: Usha Kasid, Isamu Sakabe, Imran Ahmad
  • Chemosensitizing with liposomes containing oligonucleotides
    Publication number: 20030215489
    Abstract: The invention relates to the use of oliognucleotide containing cationic liposomal formulations to enhance the efficacy of chemotherapy and/or radiotherapy, particularly as a means to chemosensitize cancer are tumor tissues to the efficiencies of chemotherapy. This is particularly advantageous in the context of treatment of ras expressing tumors such as breast, lung, pancreatic and prostate cancer.
    Type: Application
    Filed: February 15, 2002
    Publication date: November 20, 2003
    Applicant: Georgetown University
    Inventors: Usha Kasid, Prafulla Gokhale, Jin Pei, Rajshree Mewani, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
  • Use of nitroxides for the treatment of essential hypertension
    Patent number: 6617337
    Abstract: The present invention encompasses methods of treating patients for essential hypertension. The invention also includes related pharmaceutical compositions of nitroxides. Specific drugs, such as 4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (Tempol) are disclosed. These compositions are also contemplated for use in the treatment of oxidative stress and modulation of blood pressure.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: September 9, 2003
    Assignee: Georgetown University
    Inventor: Christopher S. Wilcox
  • Fluorometric assay for detecting nucleic acid cleavage
    Publication number: 20030165908
    Abstract: A method of detecting an enzyme-mediated DNA cleavage reaction in a fluorometric assay is provided. The method can be used to detect DNA cleavage caused by restriction endonucleases, retroviral integrase enzymes, DNases, RNases, or enzymes utilized in other strand separating processes in molecular biology.
    Type: Application
    Filed: July 10, 2002
    Publication date: September 4, 2003
    Applicant: Georgetown University
    Inventors: Myun Ki Han, S. Paul Lee, Jack G. Chirikjian
  • Bicyclic metabotropic glutamate receptor ligands
    Patent number: 6610743
    Abstract: The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: August 26, 2003
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Darryl Hugh Steensma, Werner Tueckmantel, Gian Luca Araldi
  • Recombinant proCVF
    Patent number: 6607897
    Abstract: Recombinant proCVF exhibits substantially the same activity as CVF and is useful for lowering complement activity.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: August 19, 2003
    Assignee: Georgetown University
    Inventors: Carl-Wilhelm Vogel, Reinhard Bredehorst, David Fritzinger, Michael Kock
  • Monomeric and dimeric heterocycles, and therapeutic uses thereof
    Patent number: 6605621
    Abstract: The invention provides compounds of formula(I): X—L—X1  (I) wherein X, L, and X1 have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a compound of formula I; intermediates and methods useful for preparing a compound of formula I; and therapeutic methods for treating drug addiction, Parkinson's disease, depression, or a disease wherein the administration of cocaine is indicated, comprising administering a compound of formula I or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: August 12, 2003
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Gian Luca Araldi, Amir P. Tamiz
  • Synthesis of 2-hydroxymethylglutamic acid and congeners thereof
    Patent number: 6599940
    Abstract: One aspect of the present invention relates to 2-hydroxymethylglutamic acid and congeners thereof. A second aspect of the invention relates to a method of synthesizing 2-hydroxymethylglutamic acid and congeners thereof.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: July 29, 2003
    Assignee: Georgetown University
    Inventor: Alan P. Kozikowski
  • ERbB-4 targeted ribozymes
    Patent number: 6566104
    Abstract: Enzymatic RNA molecules which cleave ErbB-4 mRNA and uses thereof.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: May 20, 2003
    Assignee: Georgetown University
    Inventors: Careen K. Tang, Marc E. Lippman
  • Cationic liposomal delivery system and therapeutic use thereof
    Patent number: 6559129
    Abstract: The invention relates to novel cationic lipid formulations and use thereof for treatment of cancer, especially in combination with radiation.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: May 6, 2003
    Assignee: Georgetown University
    Inventors: Usha Kasid, Prafulla Gokhale, Chuanbo Zhang, Anatoly Dritschilo, Aquilar Rahman
  • Malaria vaccine based upon the addition of a MSA1 peptide
    Patent number: 6551586
    Abstract: The present invention relates to an expression vector which expresses a malaria MSA1 peptide in combination with a signal peptide and anchor peptide in a host animal. The MSA1 peptide is combined with a signal peptide and anchor peptide for expression. Chimeric peptides being expressed with both signal peptides and anchor peptides were the most effective in eliciting an immunogenic response from a vaccinated host.
    Type: Grant
    Filed: November 27, 1998
    Date of Patent: April 22, 2003
    Assignee: Georgetown University
    Inventors: Eugene A. Davidson, Shutong Yang
  • Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
    Patent number: 6528499
    Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: March 4, 2003
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan