Abstract: A novel class of tetrapeptide .alpha.-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M.sub.1 --AA.sup.1 --AA.sup.2 --AA.sup.3 --AA.sup.4 --CO--NR.sub.3 R.sub.4.

Abstract: This invention relates to a self-expanding intraluminal composite prosthesis comprised of a rigid reinforcing component and sealing component. The prosthesis may be fabricated as either a straight or bifurcated tubular structure and is applicable to the treatment of any bodily passage including, but not limited to, vascular applications, e.g., aneurysms, arteriovenous fistulas, as well as stenotic regions of the peripheral circulation which have been percutaneously dilated but are at high risk for restenosis. The major attributes of this prosthesis can include the use of a unique multilayered biaxial braid which thereby creates a homogeneously blended composite with isotropic deformation and expansion characteristics and an associated high contraction ratio. The use of multiple layers allows for the fabrication of a device of varied porosity while retaining adequate tensile or mechanical wall strength.

Abstract: Novel quaternary pyridinium compounds useful in inhibiting acetylcholinesterase in mammals of the general structure: ##STR1## or pharmaceutically acceptable salts thereof, where R.sub.5 is pentafluorophenyl, phenyl monosubstituted with K, phenyl disubstituted with K, phenyl trisubstituted with K, or naphthyl; R.sub.6 is H, C.sub.1-6 alkyl, phenyl, pentafluorophenyl, phenyl mono, di, or trisubstituted with K, C.sub.1-6 alkyl with an attached phenyl group, C.sub.1-6 alkyl with an attached phenyl group mono, di, or trisubstituted with K; K is halogen, COOH, OH, CN, NO.sub.2, NH.sub.2, C.sub.1-6 alkyl, C.sub.1-6 fluorinated alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylamine, C.sub.1-6 alkyl--O--CO--, C.sub.1-6 alkyl--CO--NH--, C.sub.1-6 alkyl--NH--CO--NH--, C.sub.1-6 alkyl--NH--CO--O--, C.sub.1-6 alkyl--NH--CO--, or (C.sub.1-6 alkyl).sub.2 N--CO--; X is OH, C.sub.1-6 alkyl--NH--CO--O--, (C.sub.1-6 alkyl).sub.2 --N--CO--O--, C.sub.1-6 fluoroalkyl--NH--CO--, or (C.sub.1-6 fluoroalkyl).sub.

Abstract: Peptidyl derivatives of diesters of .alpha.-aminoalkylphosphonic acids with basic substitutents, their use in inhibiting serine proteases with trypsin-like specificity and their roles as anti-inflammatory agents, anticoagulants, and anti-tumor agents.

Abstract: Fluorescent 1-peptidylaminoalkanephosphonate derivatives, and their use in detecting and studying the distribution of serine proteases in cells and biological systems.

Abstract: A method for applying coatings to substrates using combustion chemical vapor deposition by mixing together a reagent and a carrier solution to form a reagent mixture, igniting the reagent mixture to create a flame, or flowing the reagent mixture through a plasma torch, in which the reagent is at least partially vaporized into a vapor phase, and contacting the vapor phase of the reagent to a substrate resulting in the deposition, at least in part from the vapor phase, of a coating of the reagent which can be controlled so as to have a preferred orientation on the substrate, and an apparatus to accomplish this method.

Abstract: A novel class of peptide .alpha.-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M.sub.1 -AA-NH--CHR.sub.2 --CO--CO--NR.sub.3 R.sub.4, M.sub.1 -AA.sub.2 -AA.sub.1 -CO--NR.sub.3 R.sub.4, M.sub.1 -AA-AA-AA-CO--NR.sub.3 R.sub.4, M.sub.1 -AA-AA-AA-AA-CO--NR.sub.3 R.sub.4, or M.sub.1 -AA-CO--NR.sub.3 R.sub.4.

Abstract: A method for forming a ceramic fabric by removing a carbon substrate from a fibrous preform by oxidation. Ceramic coated carbon fibers are laid-up in layers to form a preform. The layers generally have dimensions of from several inches to a few feet depending on the size of the preform. The carbon is exposed at any place where the fiber "ends" have been made by cutting the preform. The carbon core can be easily and economically oxidized at this point, leaving the ceramic coating as the ceramic fabric.

Abstract: Apparatus and methods for characterizing biological tissues and other turbid media with normalization that serves to compensate for the effects of scattering, reflectance, and absorption are disclosed.

Abstract: A device for applying an evaporation-inhibiting film to an exposed liquid surface of a liquid body, which includes an impeller disposed below and coplanar with the exposed liquid surface; means for rotating said impeller; means for delivering the evaporation-inhibiting film to the exposed liquid surface at a location immediately above said impeller; and means for bringing liquid from beneath the exposed surface of the liquid body to above said impeller.

Abstract: Peptidyl derivatives of diesters of .alpha.-aminoalkylphosphonic acids, particularly those with proline or related structures, their use in inhibiting serine proteases with chymotrypsin-like, trypsin-like, elastase-like, and dipeptidyl peptidase IV specificity and their roles as anti-inflammatory agents, anticoagulants, and anti-tumor agents.

Abstract: A novel class of peptide .alpha.-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula Y--CO--AA.sup.2 --AA.sup.1 --CO--NH--X. Processes for the synthesis of peptidyl .alpha.-ketoamide derivatives.

Abstract: An improved ultrasonic transducer fabricated on a silicon base has a piezoelectric layer of polyvinylidene fluoride-trfluroethylene copolymer. The piezoelectric layer is sandwiched between two conductive electrodes, all of which are supported on a dielectric layer on top of the silicon base. At least one of the electrodes forms a Fresnel zone plate to focus the ultrasonic signals from the transducers. To improve the performance of the transducer, the silicon base behind the active area is removed, leaving the dielectric layer as a membrane to support the electrodes and the piezoelectric layer. The resulting void in the silicon base is filled with an acoustically matched backing, such as an epoxy, to enhance the wideband performance of the transducer. The transducer is especially suited for characterizing anatomical structures or features requiring very high resolution.

Abstract: An improved flexible towpreg article and a method of production therefor. The improved flexible towpreg article comprises a prepreg which comprises reinforcing filaments and matrix forming material comprising recycled plastics; the reinforcing filaments being substantially wetout by the matrix forming material such that the towpreg plies have a low void content compared to the multiply towpreg.

Abstract: A low sidelobe reflector for improving the test zone performance of compact ranges by shaping the edge serrations of the range reflector. The serrations provide a means for synthesizing desired illumination function tapers at the transition region near the edge of a reflector to provide low edge diffraction. Serrations with length greater than ten wavelengths and with a flower petal shape produce the least diffraction of energy into the quiet zone.

Abstract: An improved flexible towpreg tape of a known geometry and a method of production therefor. The improved flexible towpreg tape is formed from a plurality of reinforcing filaments fusion coated with matrix forming material, the reinforcing filaments being substantially wet-out by the matrix forming material, and the towpreg tape having multiple plies with an average thickness less than about 100 microns. The method of production for the improved flexible towpreg tape includes the steps of coating the reinforcing filaments with the matrix forming material in a manner causing interfacial adhesion of the matrix forming material to the reinforcing filaments; forming a towpreg by heating the matrix forming material contacting the reinforcing filaments until the matrix forming material liquefies and coats the reinforcing filaments; and forming the towpreg tape under pressure and elevated temperature in a means for creating a known tape geometry.

Abstract: A method and apparatus for producing and viewing stereoscopic images through the use of a color coded image whereby the desired depth or distance is based upon the color of the portion of the image being viewed. Therefore the parts of the image which are to appear distant are colored red whereas the parts of the image to appear in the foreground are colored blue with the middle ground or intermediate distances being colored green or yellow. The color coded image is viewed through a prism glass constructed so that blue light which passes through the prism is bent toward a sharper angle than red light. Because the apex of the prism before each eye points toward the nose or center of the glasses the eyes must then turn more inward to see a blue object than to see a red object even though they are in actuality in the same plane on the display.

Abstract: Ferrisilicate molecular sieves of the ZSM-5 type, having SiO.sub.2 /Fe.sub.2 O.sub.3 mole ratios ranging from 20 to 400, are prepared by adding a silica source and a quaternary ammonium salt in that order to an acedified solution of an iron (III) compound, crystallizing the resulting gel to form a ferrisilicate molecular sieve, and thermally treating the molecular sieve with nitrogen, air and/or steam at 300.degree. to 700.degree. C. Preferred thermal treatment comprises treating with nitrogen first, then with air or steam. Thermally treated molecular sieves contain iron both in and outside the crystal framework; most of the non-framework iron is dispersed as very finely divided iron oxides on internal surfaces. Molecular sieves are useful as catalysts in Fischer-Tropsch and other iron oxide-catalyzied reactions.

Abstract: A process for the delignification of cellulosic materials, wherein a high-yield cellulose pulp and high-value by-product, such as reactive lignins of low molecular weight are produced, which comprises degassing lignocellulosic material, rapidly heating the lignocellulosic material in a liquor comprising water, an organic solvent and a buffer thereby maintaining a substantially neutral solvent extraction, such that said lignocellulosic material is cooked in the liquor as it is heated from a temperature of 150.degree. C. to a selected maximum temperature in the range of 200.degree. to 280.degree. C.; and rapidly cooling the mixture to a temperature less than 150.degree. C. The reaction is controlled to maximize reactive lignin solvation while suppressing cellulose degradation.