Patents Assigned to Glaukos Corporation
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Publication number: 20100087774Abstract: Devices and methods for treating ocular disorders are disclosed. One ocular implant, has a substantially straight, rigid, elongate body. The body has a self-trephinating distal portion that narrows toward a distal end, and at least one inlet that communicates with at least one inner lumen that communicates with a plurality of outlets. The lumen has a sufficient length to extend from an anterior chamber of an eye to a physiologic outflow pathway. An anchor member extends from the implant.Type: ApplicationFiled: December 18, 2008Publication date: April 8, 2010Applicant: GLAUKOS CORPORATIONInventors: David S. Haffner, Gregory T. Smedley, Thomas W. Burns, Hosheng Tu
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Patent number: 7678065Abstract: The invention discloses a trabecular stent and methods for treating glaucoma. The stent may incorporate an intraocular pressure sensor comprising a compressible element that is implanted inside an anterior chamber of an eye, wherein at least one external dimension of the element correlates with intraocular pressure. In some embodiments, the sensor may be coupled to the stent. Also disclosed are methods of delivery of the stent and the sensor to the eye.Type: GrantFiled: September 24, 2004Date of Patent: March 16, 2010Assignee: Glaukos CorporationInventors: David S. Haffner, Hosheng Tu, Morteza Gharib
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Publication number: 20100056979Abstract: A trabecular pump is implantable in the eye to reduce intraocular pressure. The pump drains aqueous humor from the anterior chamber into outflow pathways, such as Schlemm's canal. A feedback system includes an intraocular pump and a pressure sensor in communication with the pump, for regulating intraocular pressure.Type: ApplicationFiled: November 13, 2009Publication date: March 4, 2010Applicant: GLAUKOS CORPORATIONInventors: Gregory Smedley, David Haffner, Hosheng Tu, Morteza Gharib
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Publication number: 20100010414Abstract: Surgical methods and related medical devices for treating ocular disorders are disclosed. Some methods relate to delivering an implant within an eye, and involve providing an elongate guide device, such as, a flexible guide member or a guide wire. A distal end of the guide device can be advanced into an anterior chamber of an eye, or through at least a portion of a site of resistance along a physiologic outflow pathway of the eye, or from an anterior chamber of the eye to a location proximate a physiologic outflow pathway of the eye. The implant is advanced along the guide device toward the guide device distal end, and is positioned to conduct aqueous humor between the anterior chamber and the physiologic outflow pathway.Type: ApplicationFiled: May 7, 2009Publication date: January 14, 2010Applicant: GLAUKOS CORPORATIONInventors: Olav B. Bergheim, Morteza (Mory) Gharib
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Publication number: 20100004580Abstract: Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemm's canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemm's canal.Type: ApplicationFiled: May 7, 2009Publication date: January 7, 2010Applicant: GLAUKOS CORPORATIONInventors: Mary G. Lynch, Reay H. Brown
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Patent number: 7563241Abstract: Medical devices and methods for treating ocular disorders, such as glaucoma, are provided. One method involves inserting an implant on one side of an eye. The implant is advanced across the optic axis to the other side of the eye and implanted in contact with a choroid. In another method the implant is inserted through an incision in the eye into an anterior chamber of the eye. The implant is advanced from the incision and across the anterior chamber into eye tissue such that the implant is in contact with at least the choroid, or the implant drains aqueous humor from the anterior chamber toward the choroid.Type: GrantFiled: November 13, 2006Date of Patent: July 21, 2009Assignee: Glaukos CorporationInventors: Hosheng Tu, Gregory T. Smedley, David Haffner, Barbara A. Niksch
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Publication number: 20090143712Abstract: Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.Type: ApplicationFiled: February 5, 2009Publication date: June 4, 2009Applicant: GLAUKOS CORPORATIONInventors: Hosheng Tu, Gregory T. Smedley, David Haffner, Barbara A. Niksch
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Publication number: 20090137983Abstract: Implants and methods for treating ocular disorders are described. One method involves providing an elongated delivery device and an implant mounted at a distal end of the delivery device. An incision is formed in eye tissue and the implant is inserted the through the incision using the delivery device. The implant is implanted at a location communicating with a physiologic outflow pathway of an eye such that a distal end portion of the implant and a proximal end portion of the delivery device are relatively disposed in a non-linear orientation during implantation. In one method, the implant is non-linear after insertion.Type: ApplicationFiled: February 5, 2009Publication date: May 28, 2009Applicant: GLAUKOS CORPORATIONInventors: Olav B. Bergheim, Morteza (Mory) Gharib
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Publication number: 20090138022Abstract: Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.Type: ApplicationFiled: February 5, 2009Publication date: May 28, 2009Applicant: GLAUKOS CORPORATIONInventors: Hosheng Tu, Gregory T. Smedley, David Haffner, Barbara A. Niksch
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Publication number: 20090076436Abstract: An implant has a tubular member with an inlet configured to receive fluid from an anterior chamber of an eye, an outlet configured to deliver fluid from the inlet to a physiological outflow pathway of the eye, and a lumen therebetween configured for substantially free flow of the fluid and which generally defines a flow axis. At the outlet of the tubular member is a distal deployable portion that has a compacted position and an expanded position. The deployable portion is configured to expand in the physiological outflow pathway of the eye and moves transversely when transitioning between the compacted and expanded positions about a pivot axis which is substantially perpendicular to the flow axis.Type: ApplicationFiled: May 4, 2005Publication date: March 19, 2009Applicant: GLAUKOS CORPORATIONInventors: Morteza Gharib, Hosheng Tu, Olav Bergheim
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Patent number: 7488303Abstract: An implant for treating an ocular disorder has a longitudinal implant axis, an outflow portion passing therethrough, a plurality of longitudinally spaced openings therein, an inflow portion, and an anchoring member that extends from the implant and is disposed distally of the openings. The outflow portion is shaped and sized to be introduced into Schlemm's canal of an eye at an angle, and received at least partially within Schlemm's canal regardless of its rotational orientation about the axis during introduction. The openings allow fluid communication from a lumen within the outflow portion to a location outside the outflow portion. The inflow portion is configured to be positioned within an anterior chamber of the eye to permit fluid communication from the anterior chamber to the outflow portion. The axis extends through a trabecular meshwork of the eye and is generally orthogonal to Schlemm's canal during the fluid communication.Type: GrantFiled: September 22, 2003Date of Patent: February 10, 2009Assignee: Glaukos CorporationInventors: David S. Haffner, Gregory T. Smedley, Thomas W. Burns, Hosheng Tu
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Publication number: 20090036819Abstract: Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.Type: ApplicationFiled: October 6, 2008Publication date: February 5, 2009Applicant: GLAUKOS CORPORATIONInventors: Hosheng Tu, Jason Artof, David Haffner
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Patent number: 7431710Abstract: Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.Type: GrantFiled: March 18, 2005Date of Patent: October 7, 2008Assignee: Glaukos CorporationInventors: Hosheng Tu, Jason Artof, David Haffner
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Publication number: 20080234624Abstract: An ocular disorder treatment implant includes an anchor and a therapeutic agent. The implant has a body with first and second end portions. The implant is configured to transport fluid from the anterior chamber of an eye to a physiological outflow pathway of the eye. The body has at least one inlet opening at the first end portion and at least one outlet opening at the second end portion such that the inlet and outlet openings are in fluid communication and define an axis therebetween. The anchor extends substantially perpendicularly to a part of the axis between the openings, and at least one outlet opening is configured to be positioned in the physiological outflow pathway. One implant has two outlet openings, and the anchor is disposed closer to one of the outlet openings.Type: ApplicationFiled: July 12, 2004Publication date: September 25, 2008Applicant: GLAUKOS CORPORATIONInventors: Olav Bergheim, Morteza Gharib
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Publication number: 20080228127Abstract: Devices and methods for treating intraocular pressure are disclosed. The devices include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The shunts are preferably implanted by ab interno procedures.Type: ApplicationFiled: November 9, 2007Publication date: September 18, 2008Applicant: GLAUKOS CORPORATIONInventors: Thomas W. Burns, David Haffner, Harold A. Heitzmann, Todd N. Fjield, Richard A. Hill
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Publication number: 20080200860Abstract: Systems and methods for treating ocular disorders are disclosed. One system has an implant and a delivery device. The implant has inlet and outlet portions, a lumen extending therebetween and communicating with inlet and outlet ports. The implant is sized so that in use aqueous humor flows from an anterior chamber of an eye through the implant and into a uveal scleral outflow path of the eye. The delivery device is configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet and inlet ports respectively communicate with the uveal scleral outflow path and the anterior chamber. One method involves advancing an implant from within the anterior chamber, and draining fluid from therein such that fluid flows into an implant inlet port and out through an implant outlet port and into the uveal scleral outflow path.Type: ApplicationFiled: April 28, 2008Publication date: August 21, 2008Applicant: GLAUKOS CORPORATIONInventors: Hosheng Tu, Gregory T. Smedley, David Haffner, Barbara A. Niksch
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Publication number: 20080183121Abstract: Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye.Type: ApplicationFiled: January 12, 2006Publication date: July 31, 2008Applicant: GLAUKOS CORPORATIONInventors: Gregory Smedley, David Haffner, Hosheng Tu
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Publication number: 20080045878Abstract: Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involve bypassing diseased trabecular meshwork with the use of a seton implant. The seton implant is used to prevent a healing process known as filling in, which has a tendency to close surgically created openings in the trabecular meshwork. The surgical method and novel implant are addressed to the trabecular meshwork, which is a major site of resistance to outflow in glaucoma. In addition to bypassing the diseased trabecular meshwork at the level of the trabecular meshwork, existing outflow pathways are also used or restored. The seton implant is positioned through the trabecular meshwork so that an inlet end of the seton implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.Type: ApplicationFiled: August 20, 2007Publication date: February 21, 2008Applicant: GLAUKOS CORPORATIONInventors: Olav Bergheim, Morteza (Mory) Gharib
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Patent number: 7331984Abstract: Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a stent implant. The stent implant is inserted into an opening created in the trabecular meshwork by a piercing member that is slidably advanceable through the lumen of the stent implant for supporting the implant insertion. The stent implant is positioned through the trabecular meshwork so that an inlet end of the stent implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.Type: GrantFiled: August 28, 2002Date of Patent: February 19, 2008Assignee: Glaukos CorporationInventors: Hosheng Tu, David S. Haffner, Gregory T. Smedley, Barbara A. Niksch, Morteza Gharib
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Publication number: 20080015488Abstract: The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.Type: ApplicationFiled: September 25, 2007Publication date: January 17, 2008Applicant: GLAUKOS CORPORATIONInventors: Hosheng Tu, Gregory Smedley, Barbara Niksch, David Haffner