Abstract: The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.
Type:
Application
Filed:
April 7, 2010
Publication date:
May 10, 2012
Applicant:
Glycom A/S
Inventors:
Gyula Dékany, Istvan Bajza, Julien Boutet, Ignacio Pérez Figueroa, Markus Hederos, Piroska Kovács-Pénzes, Lars Króger, Johan Olsson, Christoph Róhrig, Andreas Schroven, Ioannis Vrasidas
Abstract: ?-Lactosamine hydrochloride, substantially free of ?-lactosamine hydrochloride; a method of preparing ?-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallisation of ?-lactosamine hydrochloride monohydrate; a method of preparing anhydrous ?-lactosamine hydrochloride; and use of ?-lactosamine hydrochloride as a food supplement or intermediate in synthesis.
Type:
Application
Filed:
July 15, 2009
Publication date:
July 7, 2011
Applicant:
GLYCOM A/S
Inventors:
Gyula Dekany, Karoly Agoston, Istvan Bajza, Marie Bøjstrup, Ignacio Fegueroa Pérez, Lars Kröger, Christoph H. Röhrig
Abstract: A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R1, R2 and R3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R1, R2 or R3 is a carbohydrate moiety; R4 is selected from the group consisting of: H, optionally substituted C1-20-alkyl, optionally substituted heteroalkyl, optionally substituted C2-20-alkenyl, optionally substituted C2-20-alkynyl, optionally substituted C3-10-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.
Type:
Application
Filed:
November 3, 2008
Publication date:
March 10, 2011
Applicant:
Glycom A/S
Inventors:
Gyula Dekany, István Bajza, Marie Bøjstrup, Karoly Agoston, Lars Kröger, Figueroa Peréz, Christoph Röhrig, Paulo Vital, Erzsébet Czinege