Abstract: The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

Abstract: A regulation method, corresponding device, and computer program product for the additive manufacturing of a component. The method includes: a) acquiring spatially resolved temperature data for a layer built up additively during the manufacture of the component; b) determining at least one region-of-interest on the layer, which is intended to be processed during the manufacture of the component; c) classifying temperature values of the region-of-interest; d) forming an average value of the classified temperature values; and e) controlling a processing device with the formed average value as the input value in order to process the layer.

Abstract: A coupling comprising a receiving element, a securing element, a retaining element and an insertion element, wherein the securing element is adapted to be displaceable between a release position and a locking position along a displacement axis, the securing element being adapted to engage the at least one retaining element in such a manner that a displacement of the securing element from the release position in the direction of the locking position is prevented, and wherein the insertion element is adapted to interact with the at least one retaining element upon insertion of the insertion element into the receiving space of the receiving element in such a way that a displacement of the securing element from the release position into the locking position is enabled.

Abstract: A fluid connector, comprising a first connector body, a second connector body and a latching body which is configured to connect the first connector body to the second connector body, the latching body having a first non-destructively non-releasable latching device and a second non-destructively releasable latching device, the latching body being configured to be pushed both onto a radially outer side of the first connector body and onto a radially outer side of the second connector body.

Abstract: A wheel hub drive as a direct drive of a wheel of a vehicle having an electric motor preferably designed as a permanent-magnet synchronous motor (PMSM)—external rotor motor—which is substantially arranged in the region within the wheel, wherein a rotating part of a friction brake is frictionally, interlockingly, and/or integrally connected to the motor for braking. The rotating part is operatively connected to the rotor of the motor, directly or indirectly, from outside of the motor.

Abstract: An instrument configured to attach to a bone anchoring element during surgery includes an elongate portion and an end portion having a first side and an opposite second side, where the elongate portion extends away from the first side, and where an opening is defined at the second side to accommodate at least a portion of a head of the bone anchoring element. The opening of the end portion has a first section sized to permit insertion and removal of the head therethrough, and a second section forming a seat for the head. When the head is held in the seat, the seat prevents removal of the head through the opening, while the head is movable unobstructedly from the second section back towards the first section.

Abstract: The present invention provides a method of enabling a provision of public warning system, PWS, messages to a user equipment, UE, device via a non-3GPP radio network, the method comprising establishing an internet protocol security, IPSec, tunnel connection from the UE device to a non-3GPP interworking function, N3IWF, via a non-3GPP, N3GPP, radio access technology, requesting from a first core network, CN, entity a provision of public warning system, PWS, messages; and providing the first CN entity with information about a location of the UE device.

Abstract: The disclosure relates to a method for joining metal sheets resting on one another with a variable total thickness by a clinching device comprising at least one punch and a die arranged coaxially to the punch. The punch is controllable by an electronic control unit and movable in an axial direction relative to the die. The metal sheets are arranged in a plane between the punch and the die, and the penetration depth necessary for joining the metal sheets is adjustable. Before joining the metal sheets, the current total thickness is determined with the aid of the control unit and the penetration depth is set depending on the total thickness. The method includes: storing a number of different total thicknesses or total thickness ranges in the control unit, assigning a penetration depth to a total thickness or to a total thickness range, and calibrating the clinching device.

Abstract: The present invention relates to a synchronous flyback converter circuit (1) for operating an illuminant line (4) having at least one illuminant (5), more particularly having at least one light emitting diode, the synchronous flyback converter circuit (1) comprising: a transformer (T), having a primary winding (Np), which is electrically connected to a first switch (S1), and a secondary winding (Ns), which is electrically connected to an output (A1, A1?) of the synchronous flyback converter circuit via a second switch (S2), the illuminant line (4) being able to be connected to the output; and a control unit (2), which is designed to control the first switch (S1) and the second switch (S2).

Abstract: A transport and/or storage container with integrated charging function for rechargeable wireless earphones comprising a container housing, at least one receiving unit for at least partially receiving a rechargeable wireless earphone, and an electrical container charging contact for connecting the transport and/or storage container to an electrical energy source, wherein the receiving unit has an electrical coupling contact cooperating with an electrical earphone charging contact of a rechargeable wireless earphone when it is placed in the receiving unit for recharging and wherein the electrical container charging contact and the electrical coupling contact are in the form of mutually complementary electrical contacts.

Abstract: A component wall of a hot gas component for a gas turbine, which in a double-walled design, has an outer wall which is hotter and an inner wall which is cooler during operation. The interior is divided by partition walls extending between the inner and outer walls. A coolant flows into the interior through inlet openings in the inner wall and out through outlet openings in the outer wall. An inlet cavity is directly connected to at least one of the inlet openings without being directly connected to outlet openings. A second cavity is provided directly next to the inlet cavity. The second cavity is directly connected, as an outlet cavity, only to at least one of the outlet openings, without being directly connected to inlet openings. The partition wall has at least one through-opening for conducting the coolant from the inlet cavity into the outlet cavity.

Abstract: The invention relates to a pipe for thermal cracking of hydrocarbons in the presence of steam, in which the feed mixture is guided through externally heated pipes, wherein the pipe extends along a longitudinal axis and has a number NT of grooves that have been introduced into the inner surface of the pipe and extend in a helix around the longitudinal axis along the inner surface, the inner surface into which the grooves have been introduced, in a cross section at right angles to the longitudinal axis, has a diameter Di and a radius r1=Di/2, the grooves in the cross section at right angles to the longitudinal axis, in their groove base, each have the form of a circular arc and the circular arc has a radius r2, and the grooves each have a groove depth TT which, in the cross section at right angles to the longitudinal axis, corresponds in each case to the smallest distance between the circle having the diameter Di on which the inner surface lies and the center of which lies on the longitudinal axis, and the

Abstract: A tool for machining a planar workpiece, comprising an upper tool having a clamping shaft and an upper main body that lie on a common positioning axis, a tool body arranged opposite to the clamping shaft on the upper main body, the tool body comprising a bending edge, and a lower tool having a lower main body that receives a rotational body that is rotatable around an axis of rotation running in a direction of the bending edge of the tool body, wherein the upper tool and the lower tool are movable towards and away from each other in a stroke direction for machining the workpiece arranged therebetween, and wherein the upper main body defines a projection surface that is perpendicular to the positioning axis and the bending edge of the tool body is adjacent tangentially to the projection surface or is outside the projection surface.

Abstract: In a method for generating a transillumination signal of a section of the subsurface, an HPEM radiation source radiates an electromagnetic pulse into the section for the purpose of exciting electromagnetically reactive structures to emit an electromagnetic response signal. For the pulse, a pulse duration of at most 500 ns, a center frequency in the range between 10 MHz and 10 GHz, and a bandwidth in the range from 10% to 150% of the center frequency is set. The transillumination signal is formed as the sum of response signals received at a measuring location. In a method for detecting a cavity in the subsurface, the above method is carried out, and the structures are detected from the transillumination signal with the aid of a detection method, and the cavity is detected if the structures satisfy a detection criterion.

Abstract: The present invention relates to an energy management method for an energy system (1) in a building. The energy system (1) comprises a plurality of uncontrollable energy consumers (HH), at least one controllable energy consumer (WP), an energy storage device (BAT), a net connection point (NAP) through which energy can be drawn from the net and/or fed into the net, and a feedback-control or control device (EMS) which is designed to feedback-control or control the at least one controllable energy consumer (WP) and the energy storage device (BAT). The plurality of uncontrollable energy consumers (HH) is configured to draw energy from the net or from the energy storage device (BAT).

Abstract: The disclosure relates to methods and systems for piercing, drilling, or cutting metal workpieces in a laser processing operation. The methods include focusing a pulsed laser beam onto a processing location on a workpiece; detecting process radiation emitted from the processing location; determining an intensity of the process radiation at a plurality of temporally sequential times during pulse pauses; determining an intensity gradient of the process radiation; comparing the intensity gradient with a gradient threshold value; and detecting a spontaneous material removal on the workpiece when the number of times the gradient threshold value has been exceeded is above a predetermined limit value. When a spontaneous material removal is detected, the system changes one or both of a laser parameter and a processing parameter of the laser processing operation. The disclosure also relates to processing machines for carrying out the methods.

Abstract: The present invention relates to a clipping machine for producing sausage-shaped products, like sausages, containing a flowable filling material in a tubular or bag-shaped packaging casing, the machine comprising a filling tube configured to feed filling material into the casing, and further comprises closing tools arranged downstream the filling tube, for closing the casing in a closing region. A housing is provided, enclosing at least the closing region, comprising at least a front wall and a first side wall, wherein the front wall is arranged at least substantially parallel to a longitudinally extending axis of the filling tube, and further comprises an opening which can be closed by a movable door element, movable between an open position, allowing access to the closing region and a closed position, covering and blocking access to the closing region.

Abstract: A new Verbena plant particularly distinguished by red and pink bi-colored flowers having white eyes, and an upright, compact, and rounded habit, is disclosed.

Abstract: A new Verbena plant particularly distinguished by red and light violet flowers with white at the base of the petals, and an upright, compact, and rounded habit, is disclosed.