Patents Assigned to Governors of the University of Alberta
  • Patent number: 10534000
    Abstract: Provided herein are methods for identifying a subject with an increased likelihood of developing or having metastatic papillary thyroid cancer (PTC), or a subject with an increased likelihood of developing or having recurrent PTC, and the treatment of such a subject.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: January 14, 2020
    Assignee: The Governors of the University of Alberta
    Inventors: Todd McMullen, Raymond Lai
  • Patent number: 10526608
    Abstract: The present disclosure relates generally to method of preparing aptamers, aptamers, and uses thereof.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: January 7, 2020
    Assignee: The Governors of the University of Alberta
    Inventors: Zhixin Wang, Hongquan Zhang, Xing-Fang Li, Xiaochun Le
  • Publication number: 20190352347
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: August 2, 2019
    Publication date: November 21, 2019
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Patent number: 10472398
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 10472399
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 10457715
    Abstract: Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: October 29, 2019
    Assignees: President and Fellows of Harvard College, The Governors of the University of Alberta
    Inventors: Adam E. Cohen, Daniel Hochbaum, Peng Zou, Samouil Leon Farhi, Robert Earl Campbell, Yongxin Zhao, Daniel Jed Harrison
  • Patent number: 10433725
    Abstract: An eye gaze and hand data capturing system for use with a human performing a manual task (such as a surgical procedure) with a hand-held instrument (such as a surgical instrument), includes subsystems for tracking pupil position head position and orientation, hand position, and force applied by the hand to an instrument, all operatively connected to a computer that repeatedly determines an eye gaze vector, the hand position and orientation, and the force applied to the instrument and records such information as a record of spatially and temporally coherent data in a database.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: October 8, 2019
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Simon Byrns, Michael Feist, Bin Zheng, Pierre Boulanger
  • Patent number: 10420815
    Abstract: Compositions and methods for inhibiting the growth of Gram-negative and/or Gram-positive bacteria and pharmaceutical compositions for treating infections of such bacteria in humans and animals are provided. An exemplary method for inhibiting the growth of Gram-negative and/or Gram-positive bacteria includes contacting the bacteria or an environment containing the bacteria with a combination of bacitracin and a gallate ester. An exemplary pharmaceutical composition includes bacitracin and a gallate ester.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: September 24, 2019
    Assignee: The Governors of the University of Alberta
    Inventors: Byeonghwa Jeon, Jong-Chul Kim
  • Patent number: 10408844
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in a subject. The methods and compositions involve measurement of at least one of proteins: IL-16, IL-7, VEGF, CXCL9, CX3CL1, CCL24, CCL19, and CCL11 in a body fluid sample of a subject suspected of having CFS/ME. Levels of one or more of the aforementioned proteins can be used to facilitate a diagnosis of a CFS/ME and/or confirm a diagnosis of CFS/ME. The methods and compositions of the present disclosure also find use in screening subjects for clinical trials and facilitating treatment decisions for a subject.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: September 10, 2019
    Assignee: The Governors of the University of Alberta
    Inventors: Abdolamir Landi, David Broadhurst, D. Lorne J. Tyrrell, Michael Houghton
  • Patent number: 10405834
    Abstract: An anatomical structure is segmented from images generated in an anatomical scan. A user input device is configured for manually identifying two or more seed points on a plurality of the images. An image processor is configured to identify an optimal path through seed points on the plurality of images with a graph search. The optimal path between corresponding seed points on different images defines a boundary contour, and the anatomical structure includes two or more boundary contour. The image processor is further configured to interpolate the boundary contours over a three-dimensional volume using cardinal splines.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: September 10, 2019
    Assignee: The Governors of the University of Alberta
    Inventors: Jacob Lester Jaremko, Abhilash Hareendranathan, Myles Mabee, Richard Thompson, Pierre Boulanger, Kumaradevan Punithakumar
  • Publication number: 20190270782
    Abstract: Disclosed are methods and pharmaceutical compositions for treating and inhibiting conical vascularization including conical vascularization associated with viral infection, chemical injury, autoimmune conditions, and post-corneal transplantation or in subjects having a PAX6 mutation associated with conical vascularization. The methods and pharmaceutical compositions are utilized in administering treatment that results in increased concentration of FOXC1 in a subject's cornea in order to treat or inhibit corneal vascularization.
    Type: Application
    Filed: February 18, 2019
    Publication date: September 5, 2019
    Applicants: Northwestern University, The Governors of the University of Alberta
    Inventors: Tsutomu Kume, Ordan Lehmann
  • Publication number: 20190271701
    Abstract: Methods for the diagnosis of CRC, colorectal polyps in general and adenomatous polyps in particular by measurement of metabolites in urine are described. In some embodiments, certain metabolites are identified as being elevated or reduced in concentration or quantity in subjects with CRC and/or colorectal polyps as compared with subjects without CRC or colorectal polyps. The measurement of these metabolites in urine can indicate the presence of CRC or colorectal polyps in general or adanomatous polyps in particular in a subject.
    Type: Application
    Filed: March 6, 2019
    Publication date: September 5, 2019
    Applicant: The Governors Of The University of Alberta
    Inventors: Richard Neil Fedorak, Haili Wang
  • Patent number: 10392426
    Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: August 27, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta, President and Fellows of Harvard College
    Inventors: Nathan Klapoetke, Edward Boyden, Yongku Cho, Brian Y. Chow, Gane K. S. Wong, Adam E. Cohen, Daniel R. Hochbaum
  • Publication number: 20190233735
    Abstract: The methods described herein provide an efficient way to remove and isolate short chain fatty acids from hydrocarbons that are produced upon the heating of a fatty acid resource. The short chain fatty acids can be continuously isolated and fed into the pyrolysis reactor, which in turn increases the overall efficiency of the production of the hydrocarbons. Alternatively, the short chain fatty acids can be isolated and used in other applications.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 1, 2019
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventor: David BRESSLER
  • Patent number: 10364440
    Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: July 30, 2019
    Assignees: Brown University, Rhode Island Hospital, The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Thomas J. Webster, Qian Chen, Yupeng Chen, Hicham Fenniri, Usha Devi Hemraz
  • Patent number: 10364208
    Abstract: Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: July 30, 2019
    Assignee: The Governors of the University of Alberta
    Inventors: Rylan Lundgren, Patrick Moon
  • Patent number: 10350246
    Abstract: The present application discloses the use of light-gated cation-selective channelrhodopsins (Ch Rs) for the optogenetic control of the secretion of a polypeptide of interest in adipocytes. Engineered adipocytes comprising a channelrhodopsin (ChR) polypeptide, and/or a nucleic acid encoding same, and a secretory polypeptide precursor comprising a bioactive polypeptide and a signal peptide suitable for secretion of the bioactive polypeptide by the engineered adipocytes, and/or a nucleic acid encoding same, are disclosed. The use of such engineered adipocytes for the management or treatment of diseases/conditions in which the secretion of a polypeptide of interest is beneficial, such as the secretion of insulin in diabetic patients, is also disclosed.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: July 16, 2019
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventor: Peter Edward Light
  • Patent number: 10344300
    Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: July 9, 2019
    Assignees: Brown University, Rhode Island Hospital, The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Yunpeng Chen, Qian Chen, Thomas J. Webster, Hicham Fenniri, Usha Devi Hemraz
  • Patent number: 10342838
    Abstract: The present disclosure embraces methodology and compositions for preparing pea seed coat fractions conferring improved health and/or other beneficial effects, and such fractions may be used in a human and/or animal diet.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: July 9, 2019
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Jocelyn Ozga, Catherine Chan, Alena Jin, Han Yang, Seyede Zohre Hashemi, Kaiyuan Yang
  • Patent number: 10300131
    Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: May 28, 2019
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Michael Houghton, John L. Law, Michael Logan, Darren Hockman, Abdolamir Landi