Patents Assigned to GPI
  • Patent number: 5801187
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: September 1, 1998
    Assignee: GPI-NIL Holdings, Inc.
    Inventors: Jia-He Li, Gregory S. Hamilton
  • Patent number: 5801197
    Abstract: This invention relates to the method of using specially formulated neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: September 1, 1998
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Patent number: 5798355
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 25, 1998
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • Patent number: 5795908
    Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: August 18, 1998
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Patent number: 5786378
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule heterocyclic thioesters and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: July 28, 1998
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • Patent number: 5721256
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: February 24, 1998
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • Patent number: 5696135
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: December 9, 1997
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins Univ. School of Medicines
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton
  • Patent number: 3936064
    Abstract: A safety ski binding wherein the boot is releasably mounted on a sole plate which in turn is releasably secured to the ski so as to be released therefrom upon the application of forces of predetermined magnitude and direction. The sole plate may be mounted on the ski by two pairs of mounting elements, one of said mounting elements in each pair being carried by said sole plate, the other mounting element in each said pair being adapted for mounting on said ski. Said pairs of mounting means may be positioned in fixed spaced relation on opposite sides of the longitudinal center of said sole plate. One or both of said pairs of mounting elements may include a plunger of low profile not projecting above the upper surface of the sole plate. One or both of said low profile plungers may be positioned below said upper surface of said sole plate.
    Type: Grant
    Filed: November 13, 1973
    Date of Patent: February 3, 1976
    Assignee: GPI
    Inventors: Frank P. D'Alessio, Erl A. Koenig