Patents Assigned to GRÜNENTHAL GMBH
  • Patent number: 11844865
    Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: December 19, 2023
    Assignee: Grünenthal GmbH
    Inventors: Johannes Bartholomäus, Heinrich Kugelmann, Elisabeth Arkenau-Maric
  • Publication number: 20230310351
    Abstract: The invention relates to a regimen for repeated treatment of a neuropathic condition, preferably peripheral neuropathic pain, comprising a first application of one or more high-concentration capsaicin and/or capsaicinoid topical dose units, preferably high-concentration capsaicin and/or capsaicinoid patches, followed by a second application of one or more high-concentration capsaicin and/or capsaicinoid topical dose units, preferably high-concentration capsaicin and/or capsaicinoid patches, wherein the time period between the first application and the second application is preferably shortened in order to increase the responder rate.
    Type: Application
    Filed: April 6, 2021
    Publication date: October 5, 2023
    Applicant: GRUENENTHAL GMBH
    Inventors: Marielle EERDEKENS, Sylvia ENGELEN
  • Publication number: 20230303573
    Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: November 14, 2022
    Publication date: September 28, 2023
    Applicant: Grünenthal GmbH
    Inventors: Sven KUEHNERT, Rene KOENIGS, Achim KLESS, Anita WEGERT, Ingo KONETZKI, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER
  • Patent number: 11739049
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: August 29, 2023
    Assignee: Grünenthal GmbH
    Inventors: Wolfgang Hell, Oswald Zimmer, Helmut Heinrich Buschmann, Joerg Holenz, Stefan Gladow
  • Publication number: 20230265078
    Abstract: The invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
    Type: Application
    Filed: July 9, 2021
    Publication date: August 24, 2023
    Applicant: Gruenenthal GmbH
    Inventors: Jo ALEN, Florian JAKOB, Sebastian KRUEGER, Philipp BARBIE
  • Publication number: 20230183222
    Abstract: The invention relates to 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: January 30, 2023
    Publication date: June 15, 2023
    Applicant: Gruenenthal GmbH
    Inventors: Sven KUEHNERT, Rene Michael KOENIGS, Achim KLESS, Anita WEGERT, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER
  • Publication number: 20230183184
    Abstract: The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: January 30, 2023
    Publication date: June 15, 2023
    Applicant: Gruenenthal GmbH
    Inventors: Sven KUEHNERT, Rene Michael KOENIGS, Florian JAKOB, Achim KLESS, Anita WEGERT, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER
  • Publication number: 20230174540
    Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: January 30, 2023
    Publication date: June 8, 2023
    Applicant: Gruenenthal GmbH
    Inventors: Sven KUEHNERT, Rene Michael KOENIGS, Florian JAKOB, Achim KLESS, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER, Klaus SCHIENE, Anita WEGERT
  • Publication number: 20230174458
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Application
    Filed: January 30, 2023
    Publication date: June 8, 2023
    Applicant: Gruenenthal GmbH
    Inventors: Andreas FISCHER, Helmut BUSCHMANN, Michael GRUSS, Dagmar LISCHKE
  • Publication number: 20230174520
    Abstract: The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: January 30, 2023
    Publication date: June 8, 2023
    Applicant: Gruenenthal GmbH
    Inventors: Sven KUEHNERT, Rene Michael KOENIGS, Achim KLESS, Anita WEGERT, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER, Klaus SCHIENE, Ingo KONETZKI
  • Publication number: 20230157977
    Abstract: The invention relates to repeated treatment of a neuropathic condition, preferably peripheral neuropathic pain, by application of one or more high-concentration capsaicin and/or capsaicinoid topical dose units, preferably high-concentration capsaicin and/or capsaicinoid patches, to patients who previously did not respond or insufficiently responded to a previous application of one or more high-concentration capsaicin and/or capsaicinoid topical dose units, preferably high-concentration capsaicin and/or capsaicinoid patches or any other high-concentration capsaicin and/or capsaicinoid formulation previously topically administered.
    Type: Application
    Filed: March 17, 2021
    Publication date: May 25, 2023
    Applicant: GRUENENTHAL GMBH
    Inventors: Marielle EERDEKENS, Sylvia ENGELEN
  • Publication number: 20230051321
    Abstract: Disclosed are non-aqueous solid and liquid compositions comprising resiniferatoxin and a surfactant. The non-aqueous solid and liquid compositions may be used to prepare aqueous compositions that are used in the treatment of pain, specifically osteoarthritis-related joint pain. Moreover, also disclosed are kits containing the non-aqueous solid and liquid compositions and a diluent and methods of preparing the compositions. The non-aqueous solid and liquid compositions allow for longer storage and recovery of resiniferatoxin compared to resiniferatoxin alone prior to reconstitution with a diluent.
    Type: Application
    Filed: October 17, 2022
    Publication date: February 16, 2023
    Applicant: GRUENENTHAL GMBH
    Inventors: Andreas BERNKOP-SCHNUERCH, Olivier VALDENAIRE, Thomas GILLER
  • Publication number: 20230025025
    Abstract: The present invention relates to compounds according to general formula (I) which act as inhibitors of NaV1.8 and can be used in the treatment of pain.
    Type: Application
    Filed: June 15, 2022
    Publication date: January 26, 2023
    Applicant: GRUENENTHAL GMBH
    Inventors: Sebastian KRUEGER, Sebastian PEIL, Clemens DIALER, Marcel MUELBAIER, Markus WAGENER, Ingo KONETZKI, Nikolay SITNIKOV, Jo ALEN, Martin PETTERSSON
  • Patent number: 11547678
    Abstract: An aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: January 10, 2023
    Assignee: Gruenenthal GmbH
    Inventors: Ulrich Reinhold, Marc Schiller, Eva Wulsten, Sabine Karine Katrien Inghelbrecht, Roger Carolus Augusta Embrechts, Ulrich Feil
  • Publication number: 20230000778
    Abstract: A scored tablet comprises Tapentadol or a physiologically acceptable salt thereof embedded in a prolonged release matrix material; wherein the scored tablet provides prolonged release of Tapentadol or the physiologically acceptable salt thereof; wherein the scored tablet has a site of mechanical weakness along which it can be manually broken into two separate halves preferably having essentially the same size, shape and weight; and wherein the in vitro release profile of the scored tablet essentially corresponds to the in vitro release profile of each of the two separate halves. Also disclosed is a process for the preparation of such a scored tablet.
    Type: Application
    Filed: September 14, 2022
    Publication date: January 5, 2023
    Applicant: GRUENENTHAL GMBH
    Inventors: Angelika ELLERMANN, Ulrike BERTRAM, Gerd BARTZ, Udo RUETTGERS
  • Publication number: 20220396578
    Abstract: The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
    Type: Application
    Filed: July 18, 2022
    Publication date: December 15, 2022
    Applicant: GRUENENTHAL GMBH
    Inventors: Jo ALEN, Florian JAKOB, Sebastian KRUEGER, Daniela FRIEBE, Stephanie HENNEN
  • Publication number: 20220372041
    Abstract: The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
    Type: Application
    Filed: July 18, 2022
    Publication date: November 24, 2022
    Applicant: GRUENENTHAL GMBH
    Inventors: Jo ALEN, Florian JAKOB, Sebastian KRUEGER, Philipp BARBIE, Daniela FRIEBE, Stephanie HENNEN
  • Patent number: 11344512
    Abstract: The use of tapentadol for the manufacture of a medicament comprising at least one administration unit A containing dose a of tapentadol and at least one administration unit B containing dose b of tapentadol, where dose a<dose b, for the treatment of pain.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: May 31, 2022
    Assignee: Grünenthal GmbH
    Inventors: Claudia Lange, Ferdinand Rombout
  • Publication number: 20220127264
    Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
    Type: Application
    Filed: January 5, 2022
    Publication date: April 28, 2022
    Applicant: GRUENENTHAL GMBH
    Inventors: Florian JAKOB, Jo Alen, Sebastian Krueger, Markus Schade, Daniela Friebe, Stephanie Hennen
  • Publication number: 20220106294
    Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Applicant: GRUENENTHAL GMBH
    Inventors: Florian JAKOB, Jo ALEN, Sebastian KRUEGER, Philipp BARBIE, Daniela FRIEBE