Patents Assigned to GRÜNENTHAL GMBH
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20200009082
    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: July 19, 2019
    Publication date: January 9, 2020
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
    Publication number: 20200009055
    Abstract: A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.
    Type: Application
    Filed: July 19, 2019
    Publication date: January 9, 2020
    Applicant: GRÜNENTHAL GMBH
    Inventors: KLAUS WENING, ANJA GEISSLER, JANA DENKER, LUTZ BARNSCHEID
  • 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES
    Publication number: 20200002319
    Abstract: The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: February 1, 2019
    Publication date: January 2, 2020
    Applicant: GRUENENTHAL GMBH
    Inventors: Sven KUEHNERT, Rene Michael KOENIGS, Achim KLESS, Anita WEGERT, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER, Klaus SCHIENE, Ingo KONETZKI
  • TAPENTADOL AS A LOCAL ANESTHETIC
    Publication number: 20190388364
    Abstract: The invention relates to a pharmaceutical composition comprising Tapentadol or a physiologically acceptable salt thereof for use in local anesthesia.
    Type: Application
    Filed: August 20, 2019
    Publication date: December 26, 2019
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes SCHNEIDER, Thomas CHRISTOPH
  • 1,3-Diaza-Spiro-[3.4]-Octane Derivatives
    Publication number: 20190382355
    Abstract: The invention relates to 1,3-diaza-spiro-[3.4]-octane derivatives, their preparation and use in medicine, particularly in various neurological disorders, including but not limited to pain, neurodegenerative disorders, neuroinflammatory disorders, neuropsychiatric disorders, substance abuse/dependence.
    Type: Application
    Filed: August 29, 2019
    Publication date: December 19, 2019
    Applicant: GRÜNENTHAL GMBH
    Inventors: Paul RATCLIFFE, Ingo KONETZKI, Nikolay SITNIKOV, Thomas KOCH, Ruth JOSTOCK
  • 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
    Publication number: 20190382407
    Abstract: The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: June 27, 2019
    Publication date: December 19, 2019
    Applicant: Grünenthal GmbH
    Inventors: Sven KUEHNERT, Rene Michael KOENIGS, Florian JAKOB, Achim KLESS, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER, Klaus SCHIENE, Anita WEGERT
  • 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
    Publication number: 20190375738
    Abstract: The invention relates to 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: June 24, 2019
    Publication date: December 12, 2019
    Applicant: Grünenthal GmbH
    Inventors: Sven KUEHNERT, Rene Michael KOENIGS, Achim KLESS, Anita WEGERT, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER
  • 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
    Publication number: 20190375754
    Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: June 24, 2019
    Publication date: December 12, 2019
    Applicant: Grünenthal GmbH
    Inventors: Sven KUEHNERT, Rene KOENIGS, Achim KLESS, Anita WEGERT, Ingo KONETZKI, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER
  • 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
    Publication number: 20190375718
    Abstract: The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.
    Type: Application
    Filed: June 24, 2019
    Publication date: December 12, 2019
    Applicant: Grünenthal GmbH
    Inventors: Sven KUEHNERT, Rene Michael KOENIGS, Florian JAKOB, Achim KLESS, Anita WEGERT, Paul RATCLIFFE, Ruth JOSTOCK, Thomas KOCH, Klaus LINZ, Wolfgang SCHROEDER
  • Oxidation-stabilized tamper-resistant dosage form
    Patent number: 10493033
    Abstract: A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: December 3, 2019
    Assignee: GRÜNENTHAL GMBH
    Inventors: Lutz Barnscheid, Eric Galia, Sebastian Schwier, Ulrike Bertram, Anja Geissler, Kornelia Griessmann, Johannes Bartholomäus
  • PHARMACEUTICAL COMPOSITION COMPRISING (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO [CYCLOHEXANE-1,1'-PYRANO-[3,4,B]INDOL]-4-AMINE AND PARACETAMOL OR PROPACETAMOL
    Publication number: 20190350884
    Abstract: The invention relates to a pharmaceutical composition comprising a first pharmacologically active ingredient selected from (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine and the physiologically acceptable salts thereof, and a second pharmacologically active ingredient selected from paracetamol and propacetamol.
    Type: Application
    Filed: July 3, 2019
    Publication date: November 21, 2019
    Applicant: Gruenenthal GmbH
    Inventors: Stefanie FROSCH, Klaus LINZ, Klaus SCHIENE
  • Combination of selected analgesics and COX-II inhibitors
    Patent number: 10471079
    Abstract: Combinations of certain analgesics with COX-II inhibitors, related pharmaceutical compositions, including advantageous galenical forms containing these combinations, and the use of such combinations in methods of treatment, in particular for the treatment of pain.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: November 12, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Klaus Schiene, Guenter Haase, Babette-Yvonne Koegel, Elmar Friderichs, Ulrich Jahnel
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20190321358
    Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: June 28, 2019
    Publication date: October 24, 2019
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMAEUS, Heinrich KUGELMANN
  • Preparation of a powdery pharmaceutical composition by means of cryo-milling
    Patent number: 10449547
    Abstract: A method for the preparation of a powdery pharmaceutical composition composed of a pharmaceutical excipient and a pharmaceutical component, among other possible ingredients, wherein the pharmaceutical excipient is a polyalkylene glycol, the method involving grinding a mixture of the pharmaceutical excipient and the pharmaceutical component at a temperature below ambient temperature.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: October 22, 2019
    Assignee: GRÜNENTHAL GMBH
    Inventors: Alessandro Grassano, Anna Perachiotti, Matteo Minelli, Daniele Volpi
  • TITRATION OF TAPENTADOL
    Publication number: 20190290603
    Abstract: The use of tapentadol for the manufacture of a medicament comprising at least one administration unit A containing dose a of tapentadol and at least one administration unit B containing dose b of tapentadol, where dose a<dose b, for the treatment of pain.
    Type: Application
    Filed: June 12, 2019
    Publication date: September 26, 2019
    Applicant: Grünenthal GmbH
    Inventors: Claudia LANGE, Ferdinand ROMBOUT
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20190282506
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: June 7, 2019
    Publication date: September 19, 2019
    Applicant: GRÜNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMAEUS, HEINRICH KUGELMANN
  • Treatment of Pain Associated with Trigeminal Neuralgia
    Publication number: 20190274974
    Abstract: The use of tapentadol for the treatment of pain associated with disorders of the trigeminal nerve, in particular for use in the treatment of pain associated with trigeminal neuralgia.
    Type: Application
    Filed: May 28, 2019
    Publication date: September 12, 2019
    Applicant: GRUENENTHAL GMBH
    Inventors: Thomas CHRISTOPH, Jean De Vry, Thomas Tzschentke, Petra Bloms-Funke, Klaus Schiene, Michel Hamon
  • TAMPER-RESISTANT TABLET PROVIDING IMMEDIATE DRUG RELEASE
    Publication number: 20190269621
    Abstract: The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.
    Type: Application
    Filed: May 20, 2019
    Publication date: September 5, 2019
    Applicant: Grünenthal GmbH
    Inventors: Sebastian SCHWIER, Marcel Haupts, Udo Rüttgers, Lutz Barnscheid, Jana DENKER
  • Method of inhibiting chronification of pain
    Patent number: 10398657
    Abstract: The use of tapentadol in the treatment of pain and/or pain chronification in a subject suffering from pain chronification and/or in the treatment of pain and inhibition of pain chronification in a subject suffering from pain and at risk of pain chronification, as well as the use of tapentadol for the treatment or inhibition of migraine.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: September 3, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Klaus Schiene, Ilona Steigerwald, Michel Hamon, Johannes Schneider, Silvia Reinartz, Ulrich Jahnel, Thomas Tzschentke
  • Method of treating psoriatic arthritis, psoriasis, and chronic obstructive pulmonary disease with a novel 2,5-substituted pyrimidines
    Patent number: 10391099
    Abstract: The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: August 27, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Antonio Nardi, Florian Jakob, Ingo Konetzki, Tobias Craan, Christian Hesslinger