Abstract: Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to the formula: ##STR1## wherein: R=--H, --A, --CH.sub.2 --Q, --COA or --COZ,A=lower alkyl,Z=monocyclicaryl,Q=phenyl, tolyl or xylyl,X=--H, --A, --Z or --CH.sub.2 --Z, andY=--H, --A, --Z, --CH.sub.2 --Z, --COA, --COZ,the acid-addition salts, the octahydro and 23,24-dihydro derivatives thereof.

Abstract: This invention relates to antiviral organic compositions and derivatives thereof; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are derived from marine sponges of the genus Epipolasis.

Abstract: This invention relates to antiviral and antitumor compositions, a process for producing the compositions and a method for inhibiting viruses and tumors utilizing the compositions. More particularly, the compositions are cyclohexadienone derivatives which are derived from red alga Desmia hornemanni.

Abstract: A method for determining position of and/or for positioning an object relative to both (a) its distance to a surface and (b) the orientation of its longitudinal axis to such surface involves emitting in a first plane toward such surface a plurality of first beams of coherent light from a first position adjacent the object so such first plane is at an acute angle relative to the object's longitudinal axis and the first beams of light project forward of the object to cross such longitudinal axis at such acute angle thereby forming on the surface a pattern of the illuminations of the first beams. Simultaneously, second beams are similarly emitted in a second plane toward the surface from a second opposed position adjacent the object to thereby form on the surface a pattern of illuminations of the second beams.

Abstract: A new class of novel, biologically active sesquiterpene compounds, pharmaceutical compositions containing them, methods of producing the compounds and compositions and methods of using them are disclosed. This new class of compounds have the generic formulae: ##STR1## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 =H or lower alkyl.

Abstract: This invention relates to antiviral compositions, a process for producing the compositions and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are halogenated chamigrenes extracted from sea hares which diet upon red algae.

Abstract: Apparatus for the cultchless cultivation of marine bivalve mollusks, e.g., oysters and clams, has a plurality of quadilrateral compartments connected together by a pair of longitudinal cords in the form of a continuous belt. In use of the apparatus, spat is placed in the culture chambers of the belt which then is immersed in an aquaculture plot and the spat is allowed to grow in such chambers. Later, portions of the belt are lifted out of the water while allowing the remainder of the belt to remain immersed and compartments in the withdrawn portion of the belt are cleaned and/or opened to process mollusks contained therein.

Abstract: A device for interchanging tools on a mechanical manipulator arm includes a male locking cone unit, a female receptacle cone unit and a motor unit. The male locking cone unit has 3, 6 or 12 equal size balls captured in a male conical cage to extend through its external surface. The female receptacle cone unit that carries a tool includes a dished member having an internal conical surface mating with the external surface of the locking cone, a groove in the conical surface contoured to embrace portions of the balls positioned therein and lands in the groove dividing it into 8 sections of substantially equal length. The lands prevent the balls when in the groove from moving from one of the sections to another. The motor unit, which axially connects via a power take off system with the tool to operate it, is mounted on the female receptacle cone unit.

Abstract: This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge genus Haliclona.

Abstract: This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Amphimedon sp.

Abstract: This invention relates to novel compositions which are useful as antitumor compositions, a process of producing the compositions and a method for inhibiting tumors, utilizing the compositions. More particularly, the novel compositions are indole alkaloid compositions which are derived from marine sponges of the family Biemnidae.

Abstract: This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Xestospongia, sp.

Abstract: This invention relates to antitumor cyclohexanone compositions and derivatives thereof, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are cyclohexanone and derivatives thereof which are derived from marine organisms, i.e., the acord worm, Ptychodera sp.

Abstract: The invention comprises antitumor compounds of the formula: ##STR1## wherein R is an alkyl group of up to 20 carbon atoms.

Abstract: Underwater photography apparatus of the type disclosed in U.S. Pat. No. 4,707,094 is improved to overcome problems from backgrounds or other "non-clear water" conditions by inclusion of a nulling loop in the operating circuitry. Such nulling loop includes a synchronous linear modulator, an algebraic subtracter, a synchronous demodulator and a low-pass filter.

Abstract: A new biologically active compound discorhabdin D, pharmaceutical compositions containing same, methods of producing the compound and compositions and methods of using them are disclosed.

Abstract: Novel sesterterpene compounds are derived from marine sponges of the genus Ircinia. These compounds and pharmaceutical compositions containing them as active ingredients are useful in the treatment of fungal infections.

Abstract: Production of macroalgae, e.g., Gracilaria, in a marine culture system is enhanced by improving the manner in which the aqueous culture medium is created, namely, first adjusting the alkalinity of a quantity of freshwater by the addition of an alkaline reagent thereto, diluting seawater with such alkalinity adjusted freshwater to create a saline solution having a salinity of between about 15 to 25 parts per thousand and an alkalinity of between about 3 to 10 meq/l., dissolving carbon dioxide in the resulting solution to bring its pH to between about 7.5 and 8.5, and using such carbon dioxide enriched solution as the culture medium.

Abstract: Mycalamide compounds are derived from marine sponges of the genus Mycale or prepared by synthetic methods. These compounds and pharmaceutical compositions containing them as active ingredients are useful as antitumor and antiviral agents.

Abstract: Novel alkaloid compounds that are derivatives of methaniminoetheno[d,e]acridine are derived from marine sponges of the genus Dercitus. These compounds and pharmaceutical compositions containing therapeutic effective amounts thereof are useful as antitumor and immunomodulatory medications.