Patents Assigned to Harbor Branch Oceanographic
-
Patent number: 4866084Abstract: A new class of novel, biologically active bisindole alkaloid compounds, which have been named topsentins, pharmaceutical compositions containing them, methods of producing the compounds and methods of using them are disclosed. This new class of compounds has the generic formula: ##STR1## R.sup.1-8 are the same or different selected from --H, --OH, halogen, --R, --OR, --OCOR, or --OA;Y is the single group --O, or two groups, same or different, selected from --H, --OH, --OR, or --OCOR with the provision that Y shall not be two --OH groups;Z are the same or different selected from --H, --R;R is C1-5 alkyl and A is --R--phenyl.The compounds are antiviral agents and antitumor agents which are effective against specific tumors.Type: GrantFiled: December 19, 1988Date of Patent: September 12, 1989Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Sue S. Cross, Yoel Kashman, May S. Lui, Kenneth L. Rinehart, Shinji Tsujii
-
Patent number: 4859782Abstract: This invention relates to novel macrolide compositions which are useful as antitumor, antiviral and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, viruses and fungi utilizing the compositions. More particularly, the novel macrolide compositions are organic misakinolide and misakinolide derivative compositions which are derived from marine sponges genus Theonella.Type: GrantFiled: May 18, 1987Date of Patent: August 22, 1989Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Tatsuo Higa, Ryuichi Sakai, May S. Lui
-
Patent number: 4851441Abstract: This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are tubastrines derived from marine coral Tubastrea aurea.Type: GrantFiled: January 28, 1988Date of Patent: July 25, 1989Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Tatsuo Higa, Ryuichi Sakai
-
Patent number: 4808590Abstract: This invention relates to novel compositions which are useful as antitumor, antiviral and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, viruses and fungi utilizing the composition. More particularly, the novel compositions are derived from marine sponge Theonella sp.Type: GrantFiled: July 15, 1988Date of Patent: February 28, 1989Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Tatsuo Higa, Shinichi Sakemi, Sue S. Cross
-
Patent number: 4801607Abstract: This invention relates to antitumor and antiviral furanoditerpenoid compositions, a process of producing the compositions and a method for inhibiting tumors and viruses utilizing the compositions. More particularly, the new compositions are antitumor and antiviral furanoterpenoids which are derived from marine organisms, i.e., the marine sponge Spongia sp.Type: GrantFiled: March 25, 1987Date of Patent: January 31, 1989Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Shigeo Komoto, Oliver J. McConnell, Sue S. Cross
-
Patent number: 4801606Abstract: This invention relates to novel compositions which are useful as antitumor, antiviral and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, viruses and fungi utilizing the composition. More particularly, the novel compositions are derived from marine sponge Theonella sp.Type: GrantFiled: July 17, 1987Date of Patent: January 31, 1989Assignee: Harbor Branch Oceanographic Institution Inc.Inventors: Tatsuo Higa, Shinichi Sakemi, Sue S. Cross
-
Patent number: 4777501Abstract: An underwater visual recording system capable of making consistently in-focus visual records of submarine objects includes a camera having a lens system with a predetermined depth-of-field, a first laser structured to emit a beam of coherent light of a first wavelength range, e.g. green light, a second laser structured to emit a beam of coherent light of a second wavelength range different from the first wavelength range, e.g. red light, and a support that holds the first laser spaced apart from the second laser with the camera therebetween so that the two laser beams project forward of the camera and cross one another within the camera's depth of field. In use of the system, it is positioned so the point of crossing of the laser beams is on the submarine object and then the camera is operated to make a visual recording.Type: GrantFiled: April 20, 1987Date of Patent: October 11, 1988Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Frank M. Caimi, Robert F. Tusting
-
Patent number: 4772609Abstract: This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are tubastrines derived from marine coral tubastrea aurea.Type: GrantFiled: June 26, 1986Date of Patent: September 20, 1988Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Tatsuo Higa, Ryuichi Sakai
-
Patent number: 4755529Abstract: This invention relates to novel guaiazulene compositions which are useful as antitumor, immunomodulatory and antifungal compositions and a process of producing guaiazulene compositions and a method for immunomodulation and inhibiting tumors and fungi utilizing guaiazulene compositions. More particularly, the compositions are derived from marine gorgorian Acalycigorgia, sp.Type: GrantFiled: June 26, 1986Date of Patent: July 5, 1988Assignee: Harbor Branch Oceanographic Institution Inc.Inventors: Tatsuo Higa, Shinichi Sakemi
-
Patent number: 4749787Abstract: This invention relates to a chemical process of producing an antitumor alkaloid. More particularly, it relates to a method of isolation of vinblastine from Catharanthus roseus, comprising the steps of: extracting C. roseus leaves with an acidified aqueous solution; raising the pH and extracting an alkaloid mixture with an organic solvent; chromatographing a solution of the alkaloid mixture over dextran and silica gel columns to obtain vinblastine containing fractions for isolation.Type: GrantFiled: October 23, 1986Date of Patent: June 7, 1988Assignee: Harbor Branch Oceanographic Institution, Inc.Inventor: Sarath P. Guanasekera
-
Patent number: 4731377Abstract: This invention relates to cyclic peroxide compositions, a process of producing the compositioning and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are cyclic peroxides which are derived from marine organisms, i.e., the marine sponge Plakortis lita.Type: GrantFiled: January 31, 1986Date of Patent: March 15, 1988Assignee: Harbor Branch Oceanographic Institute, Inc.Inventors: Tatsuo Higa, Carsten Christophersen, Shinichi Sakemi
-
Patent number: 4731366Abstract: This invention relates to novel discorhabdin compositions which are useful as antitumor, antibacterial and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, bacteria and fungi utilizing the compositions. More particularly, the novel discorhabdin compositions are organic compounds which are derived from marine sponges genus Latrunculia.Type: GrantFiled: August 5, 1986Date of Patent: March 15, 1988Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Murray H. G. Munro, Nigel B. Perry, John W. Blunt
-
Patent number: 4729996Abstract: This invention relates to antitumor compositions and derivatives thereof, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are derived from marine organisms, i.e., marine sponges Teichaxinella morchella and Ptilocaulis walperis.Type: GrantFiled: May 29, 1986Date of Patent: March 8, 1988Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Amy E. Wright, Winnie C. Thompson
-
Patent number: 4724314Abstract: Radiation from coupled-cavity lasers is used to measure certain characteristics of materials, e.g., absorption, reflectance and other complex dielectric constants of solids, liquids and gases. Novel laser systems with electronic feedback loops are disclosed which provide compensation for laser changes with moderate temperature variations resulting in improved measurement accuracy without adversely affecting system power efficiency. In a preferred embodiment, the invention is used in the measurement of optical attenuance in submarine water over long path-lengths and at relatively specific wavelengths, e.g., about 800 nm.Type: GrantFiled: August 21, 1986Date of Patent: February 9, 1988Assignee: Harbor Branch Oceanographic Institution Inc.Inventor: Frank M. Caimi
-
Patent number: 4714288Abstract: A device with which a tow line may be attached to a towed object, e.g., a submarine vessel, and then detached remotely includes a body member, a trip member, a latch and a keeper member. The body member has a pivot portion and an integral tow portion. The pivot portion includes a first arcuate section integral with the tow portion, a second arcuate section hinged to the first arcuate section and fastener means to forceably close the second section upon the first section forming a circular opening in the the pivot portion, which opening serves as the means for connection of the device to the towed object. The tow portion is J-shaped while the trip member is C-shaped and is pivoted on the tow portion to swing between a latched position and a release position. The latch includes a hook member pivoted on the tow portion and a ledge on the trip member is positioned so that the hook member can engage the ledge to retain it in the latched position.Type: GrantFiled: April 13, 1987Date of Patent: December 22, 1987Assignee: Harbor Branch Oceanographic Institution Inc.Inventor: Richard C. Tietze
-
Patent number: 4708962Abstract: This invention relates to antitumor compositions, and a method for inhibiting, remitting or controlling the growth of tumors or tumor cells utilizing antitumor compositions. More particularly, the antitumor compositions comprise, as active ingredient, an antitumor effective amount of halogenated chamigrenes extracted and derived from red alga and sea hares which diet upon red alga.Type: GrantFiled: September 4, 1985Date of Patent: November 24, 1987Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Tatsuo Higa, Kenneth M. Snader
-
Patent number: 4707094Abstract: Submarine photography apparatus includes a camera to record scenes in a selected sector forward thereof; a source of light having a wavelength in the range between about 650 and 700 nm. designed to project from a position lateral of the camera a conical light beam so that it intersects the sector; and a system of optical and electronic elements to detect and measure the intensity of reflected light from a photographic subject within a conical volume that has its apex lateral of the camera and extends toward the sector to intersect the light beam so that the intersecting peripheries of the light beam and the conical volume substantially define the sector. Methods of photographing with the apparatus include flashing a strobe light and exposing the camera when the system measures an intensity of the reflected light above a predetermined minimum value within the sector.Type: GrantFiled: March 21, 1986Date of Patent: November 17, 1987Assignee: Harbor Branch Oceanographic Institution Inc.Inventor: Robert F. Tusting
-
Patent number: 4680513Abstract: A control device for a reversible D.C. electric motor to protect it against damage upon reversal has a input switch circuit for reversing the flow of current through the motor's armature for reversing the direction of rotation of the motor, a first control circuit for preventing flow of current via the input switch circuit to the armature initially upon current reversing and a second control circuit for periodically interrupting the flow of current while the motor gains rotational speed after being reversed in relation to the magnitude of the flow of current through the armature. The first control circuit includes a detector circuit for determining the voltage drop existing across the armature and an automatic switch unit for (1) blocking flow of current from the input switch means to the armature until the voltage drop is determined by the detector circuit to be in a predetermined range and (2) allowing flow of the current while the voltage drop is determined to be within the range.Type: GrantFiled: August 11, 1986Date of Patent: July 14, 1987Assignee: Harbor Branch Oceanographic Institute Inc.Inventor: Gregory C. Kennedy
-
Patent number: 4676097Abstract: Rotary type knotmeters designed to detect relative motion between an underwater vehicle and the water in which it is submersed at relatively great depths comprise a vaned rotor external unit, an electronic counter/display internal unit, a multiplexing transmission line connecting the external unit to the internal unit and, preferably, a brake unit to stop rotation of the rotor unit when the knotmeter is not immersed in water. The external unit comprises a plurality of spaced Hall-effect magnetic sensors that function with bi-phase electronic detectors to modulate current flowing in the transmission line to power the external unit. Such detectors count the number of rotations per unit time of the vaned rotor which is proportional to the relative motion between vehicle and water. The current is demodulated in the internal unit to produce a velocity value which is then displayed as a digital speed reading.Type: GrantFiled: October 7, 1985Date of Patent: June 30, 1987Assignee: Harbor Branch Oceanographic Institute, Inc.Inventor: Robert F. Tusting