Abstract: The present application provides progenitor cells and a preparing method thereof. The preparing method comprises obtaining a tissue sample containing myometrium from uterus, treating the tissue sample with collagenase, and culturing the treated tissue sample to obtain the progenitor cells, wherein the progenitor cell is multipotent and immunomodulatory. The present application also provides a method for treating a degenerative disease, an ischemic disease or a disease caused by abnormal immune response comprising administering the progenitor cells to a patient subjecting the disease.

Abstract: Fc domains and CH3 domains are disclosed that bind the neonatal Fc (FcRn) receptor and are at least 99% monomeric. Monomeric Fc domain molecules and CH3 domain molecules are disclosed herein that include a monomeric Fc domain or a monomeric CH3 domain and an effector molecule. In some embodiments, the monomeric Fc or monomeric CH3 domain include amino acid substitutions and/or CDR insertions in the beta strands such that they specifically bind an antigen. Methods for using these monomeric Fc domains, monomeric CH3 domains, monomeric Fc domain molecules and CH3 domain molecules are also provided.

Abstract: Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected microRNAs, including but not limited to, miR-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian brain or neurologic injuries and diseases, including in human beings.

Abstract: The present disclosure relates to cosmetics including a foam for cosmetic composition impregnation including natural rubber (NR) and hydrophobic polymer as a polymer substrate for making the foam, and a cosmetic composition including an organic ultraviolet (UV) blocking component, that is impregnated in the foam. The present disclosure has a reduction in amount of the organic UV blocking component adsorbed to the impregnation material, and can obtain an excellent UV blocking effect.

Abstract: Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.

Abstract: A thermally developable material comprising a support and having thereon at least one non-photosensitive carrier layer comprising: a binder comprising vinyl butyral repeat units and alcohol repeat units, an adhesion promoting compound comprising ester repeat units, and a crosslinker comprising isocyanate repeat units; and at least one thermally developable imaging layer comprising organic silver salt grains, light-sensitive silver halide grains, a reducing agent, a binder comprising hydroxyl and butryal repeat units, and a crosslinker comprising at least one isocyanate group.

Abstract: Methods, implantable medical devices and systems configured to perform analysis of captured signals from implanted electrodes to identify cardiac arrhythmias. In an illustrative embodiment, signals captured from two or more sensing vectors are analyzed, where the signals are captured with a patient in at least first and second body positions. Analysis is performed to identify primary or default sensing vectors and/or templates for event detection.

Abstract: A liquid-containing heat filter for use with a high-intensity light, said liquid-containing heat filter comprising a substantially hollow reservoir for receiving heat-filtering liquid therein, the reservoir comprising a first optically transparent member, a second optically transparent member, and a peripheral frame for receiving and retaining said first optically transparent member and said second optically transparent member, heat-filtering liquid disposed in said substantially hollow reservoir, and a first resiliently deformable member interposed in trapped relation between the first optically transparent member and a first portion of said peripheral frame, wherein, in use, when the heat-filtering liquid in the reservoir raises in temperature due to the heating effect of the high-intensity light, the first resiliently deformable member is compressed to thereby allow the outward movement of the first optically transparent member due to expansion of the heat-filtering liquid.

Abstract: A method of reducing or inhibiting the contraction or communication of viral illnesses is proposed. Application of a virucidal preparation containing one or more organic acids (e.g. malic acid) with or without a surfactant (e.g. sodium C14-C16 olefin sulfonate) in a carrier agent (e.g. petrolatum) to the face of well individuals will reduce the chance that they contract illness with viral illnesses such as viral upper respiratory illnesses, influenza, viral gastroenteritis, viral rhinosinusitis, viral cold sores, and viral conjunctivitis. Application of said ointment to the nares of individuals with a VURI will reduce the chance they transmit the illness by reducing self-contamination of their hands when touching their nose. In addition, individuals suffering from a cold or influenza may reduce the duration or severity of illness by application of the nasal antiviral ointment. The ointment is most effective when applied with a clean applicator two or three times daily.

Abstract: Methods, systems and apparatus are provided for generating visual instruction to a user of a system, such as for exercise instruction or rehabilitation purposes. Preferably, the system includes a user imaging system with the system generating an output adapted to couple to a display device. The systems and methods serve to guide a user body motion. In one preferred embodiment, the method includes the steps of receiving first user positional information from the user imaging system, and then generating a first mirror image of the user positional information. Additionally, the method includes generating a first instructional image having the same positional orientation as the first mirror image of the user positional information. Finally, the method and system generate a composite output display including the first mirror image of the user positional information and the first instructional image.

Abstract: A compute device can receive a signal associated with a quantity of real-world activity (e.g., exercise) performed by a user. The compute device can define a quantity of virtual activity based, at least in part, on the quantity of real-world activity. The quantity of virtual activity can be different from the quantity of real-world activity. The compute device can send an indication of progress in a virtual world to an output device, for example, such that the user's progress is displayed.

Abstract: The present disclosure provides a deployment device that includes (a) an elongate shaft having a first end and a second end, (b) a grasping assembly coupled to the first end of the elongate shaft, where the grasping assembly includes a first jaw and a second jaw rotatable with respect to the elongate shaft, where the grasping assembly is configured to accept a wound closure device between the first jaw and the second jaw, where the wound closure device comprises at least two fixation components connected to and extending therethrough, where each of the first jaw and the second jaw include at least one coupling element configured to be removably coupled to a respective fixation component when the wound closure device is coupled to the grasping assembly, and (c) an actuator coupled to the second end of the elongate shaft, where the actuator is configured to move the grasping assembly between an open position and a closed position.

Abstract: The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation.

Abstract: Certain embodiments described herein are directed to adapters for use in coupling a direct sample analysis device to an analytical instrument such as, for example, a mass spectrometer. In some examples, the adapter can include an internal coupler separated from an external coupler through an insulator.

Abstract: An extra-oral dental imaging apparatus for obtaining an image from a patient has a radiation source; a first digital imaging sensor that provides, for each of a plurality of image pixels, at least a first digital value according to a count of received photons that exceed at least a first energy threshold; a mount that supports the radiation source and the first digital imaging sensor on opposite sides of the patient's head; a computer in signal communication with the digital imaging sensor for acquiring a first two-dimensional image from the first digital imaging sensor; and a second digital imaging sensor that is alternately switched into place by the mount and that provides image data according to received radiation.

Abstract: The present invention relates to oral compositions for identifying plaque comprising a dental disclosing agent composition for revealing the presence of dental plaque in a person's mouth including natural colorants derived from purple carrot.

Abstract: Disclosed is a compound of formula (I): wherein L, R1-R5, A, B, M, and n are as defined in the specification, as well as a method of preparing the compound. Also disclosed are a method of blood-pool imaging in a mammal and a method of imaging a lymph node in a mammal, comprising use of the compound.

Abstract: Disclosed herein are embodiments of segmented metallic guidewires that are suitable for MRI catheterization. Disclosed guidewires comprise a plurality of short conductive metallic segments that individually are short enough such that they do not resonate during MRI. The conductive segments are electrically insulated from each other and mechanically coupled together end-to-end via connectors, such as stiffness matched connectors, to provide a sufficiently long, strong, and flexible guidewire for catheterization that is non-resonant during MRI.