Patents Assigned to @HEALTH
  • Chimeric rabbit/human ROR1 antibodies
    Patent number: 9758586
    Abstract: The invention relates to antibodies having specificity for human ROR1, compositions thereof, and methods for using such antibodies, including in the diagnosis and treatment of disorders associated with aberrant ROR1 expression.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: September 12, 2017
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Christoph Rader, Jiahui Yang
  • TIME TRANSFORMATION OF LOCAL ACTIVATION TIMES
    Publication number: 20170251942
    Abstract: An automatic method of determining local activation time (LAT) from at least three multi-channel cardiac electrogram signals including a mapping channel and a plurality of reference channels. The method comprises (a) storing the cardiac channel signals, (b) using the mapping-channel signal and a first reference-channel signal to compute LAT values at a plurality of mapping-channel locations, (c) monitoring the timing stability of the first reference-channel signal, and (d) if the timing stability of the monitored signal falls below a stability standard, using the signal of a second reference channel to determine LAT values. Substantial loss of LAT values is avoided in spite of loss of timing stability.
    Type: Application
    Filed: March 7, 2016
    Publication date: September 7, 2017
    Applicant: APN Health, LLC
    Inventors: Donald Brodnick, Jasbir Sra
  • PRESCRIPTION ADHERENCE ASSISTANCE
    Publication number: 20170255759
    Abstract: Improvements to the process of providing patient assistance to conform with prescribed courses of treatment are provided. Providing assistance based on patient-specific data is implemented via an assistance analyzer communicated with a processing clearinghouse, and the process of determining how to assist the patients in adhering to their courses of treatment at the time the prescription is filled, without the patient engaging in a separate process to apply for a discount. By applying the present disclosure, existing systems improve their sensitivity to patient need when providing time sensitive information, and may be configured to use fewer processing resources than before; improving the functionality of the systems themselves.
    Type: Application
    Filed: March 7, 2016
    Publication date: September 7, 2017
    Applicant: Passport Health Communications, Inc.
    Inventor: Matthew McGrath
  • Peptide-Based Methods for Treating Pancreatic Cancer
    Publication number: 20170252396
    Abstract: Methods for treating pancreatic cancer via administration of small anti-inflammatory peptides. The peptides may be administered in conjunction with another therapeutic agent or therapeutic regimen.
    Type: Application
    Filed: October 13, 2015
    Publication date: September 7, 2017
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, Riptide Bioscience, Inc.
    Inventors: Udo Rudloff, Jesse M. Jaynes, Henry W. Lopez, George R. Martin, Clayton Yates
  • Derivatives of Bodipy
    Patent number: 9751897
    Abstract: Derivatives of BODIPY with improved properties (such as longer Stokes shift relative to existing fluorophores) are disclosed.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 5, 2017
    Assignee: Oregon Health & Science University
    Inventors: Summer Gibbs, Amy Bittel, Xiaolin Nan
  • Medical implant for fixation and integration with hard tissue
    Patent number: 9750614
    Abstract: The invention relates to medical implants, including spinal implants and bone grafts, for fixation and integration with hard tissue. The bone medical implants include at least one rotational fixation mechanism that further includes or is attached to one or more sharp protrusions configured to penetrate and become lodged into hard tissue to provide support and positional stability. Such support is useful to ensure that the spinal bone graft may be used without additional stabilizing or anchoring structures, such as supporting plates or screws.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: September 5, 2017
    Assignee: Lifenet Health
    Inventors: Jingsong Chen, Dennis Phelps, Andy T. Pritchard, Nathan Kemper, Thomas Brewer
  • Neurotoxic target for amylospheroid, method and material for reducing the neurotoxicity of amylospheroid, and use thereof
    Patent number: 9751912
    Abstract: In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells. Further, in one or a plurality of embodiments, there is provided a method and a substance for inhibiting death of mature neurons induced by the amylospheroid. In one aspect, the present disclosure relates to a use of Na+/K+-ATPase ?3 as a binding target molecule of amylospheroid. In another aspect, the present disclosure relates to a method for suppressing death of mature neurons induced by the amylospheroid, including inhibiting protein-protein interaction between the amylospheroid and the Na+/K+-ATPase ?3, and the like.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 5, 2017
    Assignee: TAO HEALTH LIFE PHARMA CO., LTD.
    Inventor: Minako Hoshi
  • Fluidic devices and methods using them
    Patent number: 9751040
    Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device can be fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: September 5, 2017
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Andrew Tipler
  • Hepatitis C virus neutralizing antibodies and methods
    Patent number: 9751931
    Abstract: Novel epitope regions on hepatitis C virus E1E2 glycoprotein that induce a neutralizing antibody response in vivo are identified. Cross-neutralizing monoclonal antibodies that bind specifically to the epitopes are disclosed.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: September 5, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Federal Budgetary Research Institution State Research Center of Virology and Biotechnology “Vector”
    Inventors: Marian Elaine Major, Alla Kachko, Galina Vadimovna Kochneva
  • Alpha-enolase specific antibodies and method of use in immune diseases
    Patent number: 9750804
    Abstract: A method for treating an inflammatory disease or an immune disorder includes administering to a subject in need of such treatment an antagonist against ENO1. The antagonist binds ENO1 and inhibits ENO1 plasminogen receptor activity. The antagonist may be an anti-human ENO1 antibody, or an scFv, Fab, or F(ab)2 fragment thereof, that specifically binds to human ENO1 (GenBank: AAH50642.1) for the treatment of an inflammatory disease or an immune disorder, which may be multiple sclerosis, rheumatoid arthritis, Crohn's disease, ulcerative colitis, systemic Lupus erythematosus, chronic obstructive pulmonary disease (COPD), asthma, allergy, psoriasis, type 1 diabetes mellitus, artherosclerosis or osteoporosis.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: September 5, 2017
    Assignees: Development Center for Biotechnology, National Health Research Institutes
    Inventors: Shih-Chong Tsai, Mingl Chang, Ta-Tung Yuan, Shih-Chi Tseng, Shyi-Jou Chen, Wei-Tso Chia, Hsin-Yun Wang, Neng-Yao Shih, Ko-Jiunn Liu, Li-Tzong Chen
  • Multifunctional oral vaccine based on chromosome recombineering
    Patent number: 9750793
    Abstract: A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome for the purpose of making multivalent vaccines to protect against one or more disease agents are described herein.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: September 5, 2017
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Madushini Nirosha Dharmasena, Dennis J. Kopecko
  • TTC8 as prognostic gene for progressive retinal atrophy in dogs
    Patent number: 9752195
    Abstract: The invention relates to the use of the TTC8 gene as a biomarker for the prognosis of a canine mammal developing progressive retinal atrophy. The invention also relates to in vitro methods of prognosing progressive retinal atrophy in a canine mammal by detecting a genetic variation within the TTC8 gene and to primers and prognostic kits for use in said method.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: September 5, 2017
    Assignee: Animal Health Trust
    Inventors: Cathryn Suzanne Mellersh, Louise Mary Downs
  • Systems and methods for automated analysis of output in single particle inductively coupled plasma mass spectrometry and similar data sets
    Patent number: 9754774
    Abstract: The present disclosure provides methods and systems for automated analysis of spectrometry data corresponding to particles of a sample, such as large data sets obtained during single particle mode analysis of an inductively coupled plasma mass spectrometer (SP-ICP-MS). Techniques are presented herein that provide appropriate smoothing for rapid data processing without an accompanying reduction (or with an acceptably negligible reduction) in accuracy and/or precision.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: September 5, 2017
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Samad Bazargan, Hamid Badiei
  • Gene and mutations thereof associated with seizure and movement disorders
    Patent number: 9752193
    Abstract: The present invention relates to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give rise to seizure and movement disorders. Accordingly, the present invention provides methods for the diagnosis or prognosis of such disorders by identifying alterations in the PRRT2 gene. Identification of alterations in the PRRT2 gene also enables the identification of subjects with an increased likelihood of having an offspring predisposed to such disorders. The present invention also provides an isolated nucleic acid molecule comprising an alteration in the PRRT2 gene, wherein said alteration produces a seizure and/or movement disorder phenotype. Also provided is an isolated PRRT2 polypeptide that comprises an alteration which produces a seizure and/or movement disorder phenotype.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: September 5, 2017
    Assignees: The University of Melbourne, Central Adelaide Local Health Network Incorporated, Itek Ventures Pty Ltd (University of South Australia)
    Inventors: Sarah Elizabeth Heron, Leanne Michelle Dibbens, Samuel Frank Berkovic, Ingrid Eileen Scheffer, John Charles Mulley
  • MAGNETIC RESONANCE MAGNIFICATION IMAGING
    Publication number: 20170248668
    Abstract: One aspect of the present disclosure provides an imaging method including: specifying an imaging focus region on a subject to be imaged, applying radiofrequency pulses to the subject to interact with a magnetic field gradient, wherein the radiofrequency pulses successively bend magnetization phases of respective electromagnetic signals from the specified imaging focus region, resulting in magnified pixel data, and generating a magnified image of the imaging focus region based on the magnified pixel data.
    Type: Application
    Filed: March 31, 2017
    Publication date: August 31, 2017
    Applicant: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventor: Jun Shen
  • METHODS TO UPREGULATE AND SUPPRESS AN EXPRESSION OF IMMUNOMODULATORY CELLS
    Publication number: 20170246212
    Abstract: The present application provides a method of upregulating an expression of immumodulatory cells in vitro comprising treating the immumodulatory cells with IL-25 to increase an expression of PD-L1. The present application also provides a method for treatment of immune disorders by the aforementioned methods. The present application also provides a method to suppress an expression of immumodulatory cells comprising suppressing an expression of PD-L1. The immumodulatory cells can be human monocytes or hMSCs. The present application further provides a method for treatment of immune-evasive diseases by using the aforementioned method to suppress an expression of immumodulatory cells.
    Type: Application
    Filed: August 26, 2015
    Publication date: August 31, 2017
    Applicant: National Health Research Institutes
    Inventors: Linju YEN, Ko-Jiunn LIU, Huey-Kang SYTWU
  • Public personalized mobile health sensing system, method and device
    Publication number: 20170247743
    Abstract: The claimed invention relates to an enhanced mobile health detection and monitoring system utilizing non-invasive saliva screening of real-time health metrics coupled with remote deep analysis of body characteristics. Health information is derived from a combination of local chemical markers which are optically collected, locally reported and broadcast over a ‘cloud based’ internet data distribution system. The disclosed system, method and related device derives personal health and wellness information by combining saliva with disposable wellness indicators which are subsequently analyzed for pharmaceutical indicators as well as DNA, RNA and protein biomarkers to provide comprehensive wellness information.
    Type: Application
    Filed: March 24, 2017
    Publication date: August 31, 2017
    Applicant: eNano Health Limited
    Inventors: Patrick Shau-park Leung, Chi Tao Leung
  • MULTIPURPOSE BOTTLE SYSTEM
    Publication number: 20170245624
    Abstract: The present invention is a multipurpose bottle that comes with multiple features and functions, such as: insulation to keep the water cool for a longer period of time, a smartphone holder, a smart phone charger, a Bluetooth speaker, an optional fragrance tab and storage space for personal items such as keys, credit cards, money, etc. The present invention provides advantages to people traveling to or from the gym or work, as this multipurpose bottle can keep water cooled, charge the smartphone and hold it, play music through the Bluetooth speaker, and provide aroma therapy while drinking and still store various important personal belongings.
    Type: Application
    Filed: November 16, 2015
    Publication date: August 31, 2017
    Applicant: Health Emporium USA LLC
    Inventor: Cezar Neves
  • PREVENTION, TREATMENT AND DIAGNOSIS OF P.GINGIVALIS INFECTION
    Publication number: 20170247420
    Abstract: The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
    Type: Application
    Filed: December 6, 2016
    Publication date: August 31, 2017
    Applicant: Oral Health Australia Pty Ltd.
    Inventors: Eric Charles Reynolds, Neil Martin O'Brien Simpson, Keith J. Cross, Nada Slakeski
  • Massage chair
    Patent number: D796219
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: September 5, 2017
    Assignee: Shanghai Roogtai Health Technology Corporation Limited
    Inventor: Qi Lin