Patents Assigned to Hexima Limited
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Patent number: 11525144Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: March 12, 2019Date of Patent: December 13, 2022Assignees: PIONEER HI-BRED INTERNATIONAL, INC., HEXIMA LIMITEDInventors: Lu Liu, Amy Lum, Azalea S. Ong, Eric Schepers, Ingrid Udranszky, Xiaohong Zhong
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Patent number: 11446354Abstract: The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.Type: GrantFiled: March 2, 2021Date of Patent: September 20, 2022Assignee: Hexima LimitedInventors: Nicole Louise van der Weerden, Marilyn Anne Anderson
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Patent number: 10973874Abstract: The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.Type: GrantFiled: April 21, 2017Date of Patent: April 13, 2021Assignee: Hexima LimitedInventors: Nicole Louise van der Weerden, Marilyn Anne Anderson
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Patent number: 10568930Abstract: Agents and formulations and cells including plant extracts are useful in a method for controlling pathogen infestation in human and animal subjects. A method for inhibiting growth or infestation of a pathogen in or on a human or animal subject, includes contacting the pathogen with an effective amount of a combination of a plant defensin or a functional natural or synthetic derivative or variant thereof and either: (i) a proteinase inhibitor; or (ii) a chemical pathogenicidic or pathogenostatic agent; in a combined amount effective to inhibit growth or infestation of the pathogen.Type: GrantFiled: April 24, 2015Date of Patent: February 25, 2020Assignee: Hexima LimitedInventors: Nicole Van Der Weerden, Marilyn Anne Anderson, Jennifer Payne
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Patent number: 10357536Abstract: The protection of plants and human and non-human subjects from pathogens enables a multivalent approach to inhibiting pathogen infection in plant and human and non-human animal subjects and to ameliorate damage to susceptible subjects. A method for protecting a subject from a disease associated with infection by a pathogen includes providing cells of said subject with a Class I defensin and a permeabilizing defensin or a precursor or a functional homolog, analog, derivative or variant thereof of either or both.Type: GrantFiled: March 23, 2018Date of Patent: July 23, 2019Assignee: Hexima LimitedInventors: Nicole Van Der Weerden, Marilyn Anne Anderson
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Patent number: 10231450Abstract: Agents and natural and synthetic formulations and extracts are useful in control of pathogen infection and infestation in humans, animals and plants, as well as pathogen contamination in environmental locales. A method inhibits growth or infection or infestation of a pathogen, including contacting the pathogen with an effective amount of a combination of a plant defensin or a functional natural or synthetic derivative or variant thereof and a non-defensin peptide, such as a cathelicidin peptide, a hairpin peptide, a hairpin peptide from which disulfide bridges have been removed, indolicidin, synthetic peptide CP-29, or a peptide derived from a cystatin. The combination of the defensin and peptide are synergistic compared to the use of each alone at the same individual dose as used in the combination.Type: GrantFiled: April 23, 2015Date of Patent: March 19, 2019Assignee: Hexima LimitedInventors: Nicole Van Der Weerden, Marilyn Anne Anderson
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Patent number: 10174339Abstract: This disclosure relates generally to the field of anti-pathogenic agents, including a modified defensin molecule with anti-pathogen activity. Genetically modified plants and their progeny or parts expressing or containing the modified defensin and anti-pathogen compositions for use in horticulture and agriculture and as animal and human medicaments are also provided.Type: GrantFiled: October 18, 2016Date of Patent: January 8, 2019Assignee: Hexima LimitedInventors: Nicole Van Der Weerden, Marilyn Anne Anderson
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Publication number: 20180193412Abstract: The present disclosure teaches the treatment or prophylaxis of infection by a microorganism including a fungus or bacterium which is infecting or colonizing an in vivo tissue, surface or membrane. The method comprising administering to the subject with the infection or directly to the site of infection a plant-derived defensin or a functional variant or derivative thereof.Type: ApplicationFiled: December 6, 2017Publication date: July 12, 2018Applicant: Hexima LimitedInventors: Nicole Louise Van der Weerden, Marilyn Anne Anderson
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Patent number: 10010576Abstract: The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.Type: GrantFiled: June 1, 2017Date of Patent: July 3, 2018Assignee: HEXIMA LIMITEDInventors: Nicole Louise Van Der Weerden, Marilyn Anne Anderson
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Patent number: 9943564Abstract: The present disclosure teaches the protection of plants and human and non-human subjects from pathogens. The present disclosure enables a multivalent approach to inhibiting pathogen infection in plant and human and non-human animal subjects and to ameliorate damage to susceptible subjects.Type: GrantFiled: November 22, 2013Date of Patent: April 17, 2018Assignee: Hexima LimitedInventors: Nicole Van Der Weerden, Marilyn Anne Anderson
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Patent number: 9896697Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: GrantFiled: March 24, 2014Date of Patent: February 20, 2018Assignee: Hexima LimitedInventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
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Patent number: 9889184Abstract: Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.Type: GrantFiled: March 15, 2013Date of Patent: February 13, 2018Assignee: Hexima LimitedInventors: Robyn Louise Heath, Marilyn Anne Anderson, Nicole Louise van der Weerden, James Anthony McKenna, Simon Poon
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Patent number: 9848603Abstract: A system for reducing the incidence or severity of fungal infection of a plant, comprising a chemical fungicide component, which may be provided by foliar or root (soil or liquid nutrient) application, together with an antifungal plant defensin not in nature expressed in the plant being protected or expressed in lower amounts or in different tissues, provides synergistic improvement in protection against infection by a plant pathogenic fungus which is susceptible to the defensin and the fungicide. The fungicide can be a strobilurin or a triazole, and the defensin can be selected from a wide range of known defensins, for example, NaD1 and others, or it can be a chimeric defensin engineered for low toxicity to the plant. The defensin can be provided as a protein formulation, optionally together with the fungicide, or it can be provided by recombinant expression in the plant to be protected from fungal infection.Type: GrantFiled: May 12, 2015Date of Patent: December 26, 2017Assignee: Hexima LimitedInventors: Marilyn Anderson, Robyn Heath, James McKenna, Nicole Van Der Weerden
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Publication number: 20170296622Abstract: The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.Type: ApplicationFiled: June 1, 2017Publication date: October 19, 2017Applicant: Hexima LimitedInventors: Nicole Louise van der Weeden, Marilyn Anne Anderson
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Publication number: 20170239328Abstract: The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.Type: ApplicationFiled: April 21, 2017Publication date: August 24, 2017Applicant: Hexima LimitedInventors: Nicole Louise Van Der Weeden, Marilyn Anne Anderson
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Patent number: 9713632Abstract: The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.Type: GrantFiled: May 29, 2015Date of Patent: July 25, 2017Assignee: Hexima LimitedInventors: Nicole Louise Van Der Weerden, Marilyn Anne Anderson
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Patent number: 9540423Abstract: The present invention relates to compositions and methods for preventing or treating proliferative diseases. In particular, the present invention relates to the use of compositions derived or derivable from plants, such as plant defensins, particularly in methods for the prevention or treatment of proliferative diseases such as cancer. The present invention also relates to associated uses, systems and kits.Type: GrantFiled: October 19, 2012Date of Patent: January 10, 2017Assignees: BALMORAL AUSTRALIA PTY LTD, HEXIMA LIMITEDInventors: Mark Darren Hulett, Fung Tso Lay
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Patent number: 9497908Abstract: This disclosure relates generally to the field of anti-pathogenic agents, including a modified defensin molecule with anti-pathogen activity. Genetically modified plants and their progeny or parts expressing or containing the modified defensin and anti-pathogen compositions for use in horticulture and agriculture and as animal and human medicaments are also provided.Type: GrantFiled: February 7, 2012Date of Patent: November 22, 2016Assignee: HEXIMA LIMITEDInventors: Nicole Van Der Weerden, Marilyn Anne Anderson
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Publication number: 20160106807Abstract: The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.Type: ApplicationFiled: May 29, 2015Publication date: April 21, 2016Applicant: Hexima LimitedInventors: Nicole Louise Van Der Weerden, Marilyn Anne Anderson
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Publication number: 20150283204Abstract: The present disclosure teaches the protection of plants and human and non-human subjects from pathogens. The present disclosure enables a multivalent approach to inhibiting pathogen infection in plant and human and non-human animal subjects and to ameliorate damage to susceptible subjects.Type: ApplicationFiled: November 22, 2013Publication date: October 8, 2015Applicant: Hexima LimitedInventors: Nicole Van Der Weerden, Marilyn Anne Anderson